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Wei Lei Fukui Shen Nianwei Chang Lin Niu Yuanyuan Hou Boli Zhang Min Jiang Gang Bai 《中国化学快报》2021,32(1):190-193
Atherosclerosis is a persistent inflammatory state,while vascular endothelial fibrosis is one of the primary causes of atherosclerosis development.Although ligustilide(Lig) was shown to exert obvious antiatherogenic effects in previous studies,its precise mechanism has not been deeply discussed.In this paper,we designed a Lig-derived photoaffinity labelling(PAL) probe to identify potential therapeutic targets of Lig via chemical proteomics approach.Mothers against decapentaplegic homologue 3(SMAD3),a signal transmitter of transforming growth factor-β(TGF-β) which promotes the development of vascular fibrosis,was identified as a potential target of Lig.Lig suppressed the phosphorylation and nuclear translocation of SMAD3 by blocking the interaction between SMAD3 and TGF-β receptor 1,thereby inhibiting the collagen synthesis process.Hence,developing a novel SMAD3 inhibitor may present a promising therapeutic option for preventing vascular fibrosis. 相似文献
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Microchimica Acta - The authors describe an amperometric sensor for dopamine (DA) which has a working potential as low as +0.02 V (vs. SCE). It makes use of a nanocomposite consisting of... 相似文献
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Magnetic nanoparticles (MNPs) were modified by polyaspartate (PAA) and poly(ethyleneimine) (PEI) via Layer-by-Layer self-assembly. Two steps were involved in: the first was to coat MNPs by PAA at pH = 6; the second was to coat the former by PEI. The successful surface modification of MNPs was confirmed using X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and fourier transform infrared (FTIR) measurements. The modified MNPs interact strongly with negative fibrinogen and weakly with neutral γ-globin and positive lysozyme. 相似文献
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Di Huang Mengjie Xu Lulu Niu Montserrat Prez Jingjing Du Yan Wei Yinchun Hu Xiaojie Lian Weiyi Chen 《先进技术聚合物》2020,31(1):36-43
Chitosan (CS) is a biocompatible, noncytotoxic biomaterial used before as base material for composites. On the other hand, nano‐hydroxyapatite (nHA) is one of the main components of human bones, highly used for biomedical applications. In this work, CS microspheres were produced under a W/O emulsion system. CS microspheres with calcium ions were then exposed to Na3PO4 solution. In situ biomimetic nHA crystals were formed on CS microspheres to generate 15.14 ± 3.15‐μm composite microspheres. The microspheres were subsequently seeded with MG63 osteoblasts to observe their cell responses. All microspheres were characterized via scanning electron microscopy (SEM), phase‐contrast photomicroscopy, and X‐ray diffraction (XRD) analysis. The results showed flake‐like shape and islet‐like growth of nHA depositions presented on the surface of the CS microspheres. In vitro tests indicated that the CS/nHA microparticles were not only biocompatible but also enhanced cell adhesion and elongation due to the in situ biomimetic synthesis method. 相似文献
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