A One Pot Synthesis of 1-Substituted-1,2,3,7-tetrahydro-8-nitroimidazo [1,2-a] [1,2,6] thiadiazine-7 (1H) one-5,5-dioxides

Reaction of chlorosulfonyl isocyanate with nitroketene aminals of imidazolidines afforded acyclic intermediates which on treatment with diisopropylamine were smoothly transformed into the corresponding 1-substituted-1,2,3,7-tetrahydro-8-nitroimidazo [1,2-a] [1,2,6] thiadiazine-7 (1H) one-5, 5-dioxides.     

H2SO4-Promoted Synthesis of (E)-Stilbenes from Substituted Phenylacetones and Substituted Benzaldehydes Through Tandem Aldol–Grob Reaction

Stilbene derivates (stilbenoids) are present in plants and show a wide range of biological activities and potential therapeutic value. In continuation of our natural product synthesis program, an efficient, simple, and practical method has been developed to regioselectively synthesize (E)-stilbenes using H₂SO₄ as a catalyst in a short time (30–60 s) at room temperature in good to excellent yields.

Oxidative iodination of carbonyl compounds using ammonium iodide and oxone®

A simple, efficient, mild, and regioselective method for oxyiodination of carbonyl compounds has been reported by using NH₄I as the source of iodine and Oxone® as an oxidant. Various carbonyl compounds such as aralkyl ketones, aliphatic ketones (acyclic and cyclic), and β-keto esters proceeded to the respective α-monoiodinated products in moderate to excellent yields. Unsymmetrical aliphatic ketones reacted smoothly yielding a mixture of 1-iodo and 3-iodo ketones with the predominant formation of 1-iodoproduct.