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991.
In this paper, we apply the disconjugacy theory and Elias's spectrum theory to study the positivity and the spectrum structure of the linear operator coupled with the clamped beam boundary conditions (1.2). We also study the positivity and the spectrum structure of the more general operator coupled with (1.2). As the applications of our results on positivity and spectrum of fourth‐order linear differential operators, we show the existence of nodal solutions for the corresponding nonlinear problems via Rabinowitz's global bifurcation theorem. 相似文献
992.
Mokhtar Kirane Salman A. Malik Mohammed A. Al‐Gwaiz 《Mathematical Methods in the Applied Sciences》2013,36(9):1056-1069
We consider the inverse source problem for a time fractional diffusion equation. The unknown source term is independent of the time variable, and the problem is considered in two dimensions. A biorthogonal system of functions consisting of two Riesz bases of the space L2[(0,1) × (0,1)], obtained from eigenfunctions and associated functions of the spectral problem and its adjoint problem, is used to represent the solution of the inverse problem. Using the properties of the biorthogonal system of functions, we show the existence and uniqueness of the solution of the inverse problem and its continuous dependence on the data. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
993.
Mohammed Berkhouch Ghizlane Lakhnati Marcelo Brutti Righi 《Applied Mathematical Finance》2013,20(3):295-314
ABSTRACTThe aim of this paper is to introduce a risk measure, Extended Gini Shortfall (EGS), that extends the Gini-type measures of risk and variability by taking risk aversion into consideration. Our risk measure is coherent and catches variability, an important concept for risk management. The analysis is made under the Choquet integral representations framework. We expose results for analytic computation under well-known distribution functions. Furthermore, we provide a practical application. 相似文献
994.
We introduce and study the class of almost weak Dunford–Pettis operators and we derive the following interesting consequence: other characterizations of the weak Dunford–Pettis property. After that we characterize pairs of Banach lattices for which the adjoint of almost weak Dunford–Pettis operator is almost Dunford–Pettis. Finally, we establish a necessary and sufficient conditions on the pair of Banach lattices E and F which guarantees that if T : E → F is a positive almost weak Dunford–Pettis then T is almost Dunford–Pettis. 相似文献
995.
Dumbre S Derouaux A Lescrinier E Piette A Joris B Terrak M Herdewijn P 《Journal of the American Chemical Society》2012,134(22):9343-9351
The peptidoglycan glycosyltransferases (GTs) are essential enzymes that catalyze the polymerization of glycan chains of the bacterial cell wall from lipid II and thus constitute a validated antibacterial target. Their enzymatic cavity is composed of a donor site for the growing glycan chain (where the inhibitor moenomycin binds) and an acceptor site for lipid II substrate. In order to find lead inhibitors able to fill this large active site, we have synthesized a series of substrate analogues of lipid I and lipid II with variations in the lipid, the pyrophosphate, and the peptide moieties and evaluated their biological effect on the GT activity of E. coli PBP1b and their antibacterial potential. We found several compounds able to inhibit the GT activity in vitro and cause growth defect in Bacillus subtilis . The more active was C16-phosphoglycerate-MurNAc-(L-Ala-D-Glu)-GlcNAc, which also showed antibacterial activity. These molecules are promising leads for the design of new antibacterial GT inhibitors. 相似文献
996.
Khalil EL KHATABI Ilham AANOUZ Reda El-MERNISSI Atul Kumar SINGH Mohammed Aziz AJANA Tahar LAKHLIFI Shashank KUMAR Mohammed BOUACHRINE 《Turkish Journal of Chemistry》2021,45(3):647
Alzheimer’s disease (AD) is a multifactorial and polygenic disease. It is the most prevalent reason for dementia in the aging population. A dataset of twenty-six 1,2,3-triazole-based derivatives previously synthetized and evaluated for acetylcholinesterase inhibitory activity were subjected to the three-dimensional quantitative structure-activity relationship (3D-QSAR) study. Good predictability was achieved for comparative molecular field analysis (CoMFA) (Q2 = 0.604, R2 = 0.863, rext2 = 0.701) and comparative molecular similarity indices analysis (CoMSIA) (Q2 = 0.606, R2 = 0.854, rext2 = 0.647). The molecular features characteristics provided by the 3D-QSAR contour plots were quite useful for designing and improving the activity of acetylcholinesterase of this class. Based on these findings, a new series of 1,2,3-triazole based derivatives were designed, among which compound A1 with the highest predictive activity was subjected to detailed molecular docking and compared to the most active compound. The selected compounds were further subjected to 20 ns molecular dynamics (MD) simulations to study the comparative conformation dynamics of the protein after ligand binding, revealing promising results for the designed molecule. Therefore, this study could provide worthy guidance for further experimental analysis of highly effective acetylcholinesterase inhibitors. 相似文献
997.
Mohammed Abouzaid 《Inventiones Mathematicae》2012,189(2):251-313
We prove that the inclusion of every closed exact Lagrangian with vanishing Maslov class in a cotangent bundle is a homotopy equivalence. We start by adapting an idea of Fukaya-Seidel-Smith to prove that such a Lagrangian is equivalent to the zero section in the Fukaya category with integral coefficients. We then study an extension of the Fukaya category in which Lagrangians equipped with local systems of arbitrary dimension are admitted as objects, and prove that this extension is generated, in the appropriate sense, by local systems over a cotangent fibre. Whenever the cotangent bundle is simply connected, this generation statement is used to prove that every closed exact Lagrangian of vanishing Maslov index is simply connected. Finally, we borrow ideas from coarse geometry to develop a Fukaya category associated to the universal cover, allowing us to prove the result in the general case. 相似文献
998.
In this paper we study the translation surfaces in the 3-dimensional Euclidean and Lorentz-Minkowski space under the condition ${\Delta ^{III}r_{i} = \mu _{i}r_{i},\mu _{i} \in \mathbb{R}}$ , where Δ III denotes the Laplacian of the surface with respect to the third fundamental form III. We show that in both spaces a translation surface satisfying the preceding relation is a surface of Scherk. 相似文献
999.
In this paper we classify the factorable surfaces in the three-dimensional Euclidean space ${\mathbb{E}^{3}}$ and Lorentzian ${\mathbb{E}_{1}^{3}}$ under the condition ??r i ?=??? i r i , where ${\lambda_{i}\in\mathbb{R}}$ and ?? denotes the Laplace operator and we obtain the complete classification for those ones. 相似文献
1000.
Mélanie Lavergne Mohammed Derkaoui Catherine Delmau Didier Letourneur Catherine Le Visage 《Macromolecular bioscience》2012,12(7):901-910
Human ECFCs contribute to vascular repair. For this reason, they are considered as valuable cell therapy products in ischemic diseases. Porous scaffolds are prepared that are composed of natural polysaccharides, pullulan and dextran, by chemical crosslinking without use of organic solvents. These porous scaffolds, which have pores with an average size of 42 µm and a porosity of 21%, preserve the viability and the proliferation of cord‐blood ECFCs. After 7 d of culture in porous scaffolds, ECFCs express endothelial markers (CD31 and vWf) and maintain endothelial functions. The cultured cells can be easily retrieved by enzymatic degradation of the porous scaffolds. In vitro results suggest that the porous scaffold could allow cell delivery of ECFCs for treatment of vascular diseases.