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81.
Grandjean C Gras-Masse H Melnyk O 《Chemistry (Weinheim an der Bergstrasse, Germany)》2001,7(1):230-239
Major histocompatibility class II antigens have been bound to clustered glycosides for selective targeting of the dendritic cell mannose receptor. Di-, tetra-, and octavalent glycoside-antigen conjugates have been obtained after two, orthogonal, hydrazone/thioether ligations, performed by using thio derivatives of D-mannose, D-galactose, or D(-)-quinic acid, glyoxylyl (or hydrazino)-N-chloroacetylated lysinyl trees, and N-terminal hydrazino (or glyoxylyl) peptide antigens. Successful one-pot condensations have been developed to account for the nature of the antigens and the valency of the trees. 相似文献
82.
H. I. Dobryanska I. V. Melnyk Yu. L. Zub A. A. Chuiko M. Barcrak A. Dabrowski 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2006,80(6):939-944
It was shown for the example of the Si(OC2H5)4/(CH3O)3Si(CH2)3SH system that successively increasing the fraction of tetraethoxysilane in it (from 1: 1 to 5: 1 (mol)) successively decreased the content of 3-mercaptopropyl groups in xerogels synthesized by the sol-gel method (in the presence of methanol as a solvent and fluorine ions as a catalyst) from 5.0 to 1.9 mmol/g, whereas the specific surface area of such xerogels simultaneously increased from 13 to 631 m2/g. The sorption volume of pores also increased, their mean diameter varying insignificantly. The mean diameter of pores (2.2–2.5 nm) was close to the boundary between meso-and micropores, which was in agreement with the form of nitrogen adsorption isotherms (type I according to the IUPAC classification). It was shown by scanning electron microscopy that virtually nonporous xerogels formed at a 1: 1 ratio between alkoxysilanes consisted of spherical partially united particles 2.5–3 μm in diameter. All the 3-mercaptopropyl groups of this and other samples were, however, accessible to silver(I) ions. It follows that these groups are situated in the surface layer of xerogels. The number of thiol groups per 1 nm2 of the surface of nonporous xerogels was 1.7–7.0 groups/nm2 and depended on the ratio between reacting alkoxysilanes and s sp. 相似文献
83.
Piret G Coffinier Y Roux C Melnyk O Boukherroub R 《Langmuir : the ACS journal of surfaces and colloids》2008,24(5):1670-1672
We report on the use of patterned superhydrophobic silicon nanowire surfaces for the efficient, selective transfer of biological molecules and nanoparticles. Superhydrophilic patterns are prepared on superhydrophobic silicon nanowire surfaces using standard optical lithography. The resulting water-repellent surface allows material transfer and physisorption to the superhydrophilic islands upon exposure to an aqueous solution containing peptides, proteins, or nanoparticles. 相似文献
84.
Claire Simonneau Bérénice Leclercq Alexandra Mougel Eric Adriaenssens Charlotte Paquet Laurent Raibaut Nathalie Ollivier Hervé Drobecq Julien Marcoux Sarah Cianférani David Tulasne Hugo de Jonge Oleg Melnyk Jér?me Vicogne 《Chemical science》2015,6(3):2110-2121
The development of MET receptor agonists is an important goal in regenerative medicine, but is limited by the complexity and incomplete understanding of its interaction with HGF/SF (Hepatocyte Growth Factor/Scatter Factor). NK1 is a natural occurring agonist comprising the N-terminal (N) and the first kringle (K1) domains of HGF/SF. In the presence of heparin, NK1 can self-associate into a “head to tail” dimer which is considered as the minimal structural module able to trigger MET dimerization and activation whereas isolated K1 and N domains showed a weak or a complete lack of agonistic activity respectively. Starting from these structural and biological observations, we investigated whether it was possible to recapitulate the biological properties of NK1 using a new molecular architecture of isolated N or K1 domains. Therefore, we engineered multivalent N or K1 scaffolds by combining synthetic and homogeneous site-specifically biotinylated N and K1 domains (NB and K1B) and streptavidin (S). NB alone or in complex failed to activate MET signaling and to trigger cellular phenotypes. Importantly and to the contrary of K1B alone, the semi-synthetic K1B/S complex mimicked NK1 MET agonist activity in cell scattering, morphogenesis and survival phenotypic assays. Impressively, K1B/S complex stimulated in vivo angiogenesis and, when injected in mice, protected the liver against fulminant hepatitis in a MET dependent manner whereas NK1 and HGF were substantially less potent. These data reveal that without N domain, proper multimerization of K1 domain is a promising strategy for the rational design of powerful MET agonists. 相似文献
85.
In the framework of relativistic harmonic confinement model for quarks and antiquarks, the masses of S- and P-wave mesons and pseudoscalar decay constants from light flavour to heavy flavour sectors are computed. The residual two-body
Coulomb interaction and the spin-dependent interaction of the confined one gluon exchange effects (COGEP) such as spin-spin
and spin-orbit interactions are perturbatively incorporated with the confinement energy to get the respective vector-pseudoscalar
meson mass differences. Here we employ the same parametrization and model parameters as used in a recent study of low-lying
hadron masses and leptonic decay widths. The results are being compared with the values obtained from other theoretical models
and the experimental values. 相似文献
86.
Klishevich G. V. Curmei N. D. Lebovka N. I. Melnyk V. I. Tereshchenko A. G. 《Journal of Applied Spectroscopy》2021,88(4):710-715
Journal of Applied Spectroscopy - Results of a comparative analysis of spectral-luminescent properties of crystalline and glassy benzophenone are presented. The main spectral characteristics... 相似文献
87.
Dr. Vincent Diemer Olga Firstova Dr. Vangelis Agouridas Dr. Oleg Melnyk 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(16):e202104229
The native chemical ligation reaction of peptide thioesters with cysteinyl peptides is a pivotal chemical process in the production of native or modified peptides and proteins, and well beyond in the preparation of various biomolecule analogs and materials. To benefit from this reaction at its fullest and to access all the possible applications, the experimentalist needs to know the factors affecting its rate and how to control it. This concept article presents the fundamental principles underlying the rate of the native chemical ligation and its homogeneous catalysis by nucleophiles. It has been prepared to serve as a quick guide in the search for an appropriate catalyst. 相似文献
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