全文获取类型
收费全文 | 1249篇 |
免费 | 34篇 |
国内免费 | 2篇 |
专业分类
化学 | 902篇 |
晶体学 | 34篇 |
力学 | 36篇 |
数学 | 113篇 |
物理学 | 200篇 |
出版年
2023年 | 8篇 |
2022年 | 15篇 |
2021年 | 44篇 |
2020年 | 36篇 |
2019年 | 34篇 |
2018年 | 19篇 |
2017年 | 20篇 |
2016年 | 49篇 |
2015年 | 35篇 |
2014年 | 40篇 |
2013年 | 54篇 |
2012年 | 90篇 |
2011年 | 108篇 |
2010年 | 56篇 |
2009年 | 67篇 |
2008年 | 87篇 |
2007年 | 70篇 |
2006年 | 54篇 |
2005年 | 52篇 |
2004年 | 38篇 |
2003年 | 43篇 |
2002年 | 36篇 |
2001年 | 13篇 |
2000年 | 17篇 |
1999年 | 16篇 |
1998年 | 11篇 |
1997年 | 11篇 |
1996年 | 19篇 |
1995年 | 4篇 |
1994年 | 10篇 |
1993年 | 13篇 |
1992年 | 12篇 |
1991年 | 5篇 |
1990年 | 11篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1982年 | 6篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1973年 | 3篇 |
1961年 | 4篇 |
1960年 | 3篇 |
1955年 | 2篇 |
1954年 | 6篇 |
1953年 | 4篇 |
排序方式: 共有1285条查询结果,搜索用时 78 毫秒
101.
Slavomíra Doktorovová Joana Araújo Marisa L. Garcia Erik Rakovský Eliana B. Souto 《Colloids and surfaces. B, Biointerfaces》2010,75(2):538-542
The aim of this study was to develop nanostructured lipid carriers (NLC) for topical delivery of fluticasone propionate (FP) with the aim to further improve the safety profile and decrease the adverse-side effects commonly reported in topical corticotherapy. NLC are colloidal drug-carriers consisting of a blend of a solid lipid and a small amount of liquid lipid since these carriers have proved to be effective in epidermal targeting in particular of glucocorticoids. NLC consisting of glyceryl palmito-stearate, and PEG-containing medium chain triglycerides mixture, stabilised by polysorbate 80 and soybean phosphatidylcholine were prepared. A mean particle size between 380 and 408 nm and entrapment efficacy of 95% were obtained for FP-loaded NLC. The crystallinity and polymorphic phase behaviour of FP-free and FP-loaded NLC were examined by differential scanning calorimetry and wide angle X-ray diffraction. Results revealed a low-crystalline structure and confirmed the incorporation of FP into the particles. The suitability of PEG-containing liquid lipids to form the lipid matrix of NLC was also confirmed. 相似文献
102.
103.
Brbara L. Almeida Joanna M. Ramos Otvio Versiani Marta Sousa Claudio Alberto Tllez Soto Ana Lúcia Ramalho Mercê Antnio Slvio Mangrich Judith Felcman 《Polyhedron》2008,27(18):3662-3668
A new complex of Cu(II) of stoichiometry [Cu(PCr)(H2O)] was prepared from aqueous solution at pH 6. Its synthesis, characterization, thermogravimetric, vibrational spectroscopy, and electron paramagnetic resonance analyses were described and suggest that phosphocreatine (PCr) in solid state is acting as a tridentate ligand (the nitrogen atom of the guanidine group and the oxygen atoms of the phosphate group and the carboxylate group being the donor atoms). The fourth position is occupied by a water molecule. These results were confirmed through computational calculations (DFT/B3LYP:6-311G theoretical procedure). The tetra coordination of Cu(II) arranged in a quadratic planar geometry was found to be more stable in the DFT calculations. The calculated vibrational spectrum agrees well with the FT-IR experimental spectrum. 相似文献
104.
105.
The numerical solution of the time‐dependent Navier–Stokes equations in terms of the vorticity and a stream function is a well tested process to describe two‐dimensional incompressible flows, both for fluid mixing applications and for studies in theoretical fluid mechanics. In this paper, we consider the interaction between the unsteady advection–diffusion equation for the vorticity, the Poisson equation linking vorticity and stream function and the approximation of the boundary vorticity, examining from a practical viewpoint, global iteration stability and error. Our results show that most schemes have very similar global stability constraints although there may be small stability gains from the choice of method to determine boundary vorticity. Concerning accuracy, for one model problem we observe that there were cases where the boundary vorticity discretization did not propagate to the interior, but for the usual cavity flow all the schemes tested had error close to second order. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
106.
We extend the trajectory scaling function as defined for maps to flows whose dynamics is governed by ordinary differential equations. The results are obtained for the Duffing oscillator and are expected to be the same for other dissipative flows as well. 相似文献
107.
The present paper reports on a modified pressure implicit predictor corrector type scheme for solving the flow governing equations, in which a consistent formulation is combined with a multi-grid solver for the pressure correction. In addition a parabolic sublayer (PSL) approach for the treatment of the flow in the vicinity of solid walls is critically evaluated in terms of accuracy and computational efficiency. The lid-driven cavity flow is chosen as the test case and results are presented for Reynolds numbers ranging from 100 to 1000. Predictions with the proposed scheme indicate substantial computational savings and fairly good agreement when compared with previous work. The PSL approach reduces the computing time, but with increasing Reynolds numbers the accuracy of the solutions tends to deteriorate. 相似文献
108.
Two new unexpected photochromic compounds were obtained from naphtho[2,1-b]pyran-1-one 1. The reaction of this ketone with the silyl enol ether methyl trimethylsilyl dimethylketene acetal, catalyzed by TiCl4, afforded the photochromic dihydronaphtho[2,1-b]pyranone 2. The Reformatsky reaction of ketone 1 with ethyl bromoacetate led to the formation of the expected alcohol that under acid treatment gave, unexpectedly, the novel photochromic benzocoumarin 6. UV irradiation compounds 2 and 6 in solution provided thermally stable photoproducts that returned to the initial uncoloured forms under visible irradiation. The photochromic behaviour of these compounds and the structures of the photoproducts formed in these reactions were characterized by 1D and 2D NMR. 相似文献
109.
A series of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones derivatives 6 and 7 was conveniently prepared. A multistep synthesis was carried out starting from dichloro- and bromoanilines (1a-b) and diethyl 2-(ethoxymethylene)malonate using a slightly modified Gould-Jacobs reaction. In this work we present a novel chlorination strategy to prepare quinoline derivatives 4 in excellent yields as key intermediates in the synthesis of the target compounds. Several reaction conditions were evaluated to optimize the formation of pyrazoloquinolinone nucleus. Differences in chemical behavior of both chloroquinolinones 4a-b with aryl and benzyl-hydrazines are also discussed. 相似文献
110.
Marcelo Kobelnik Douglas Lopes Cassimiro Clóvis Augusto Ribeiro Diógenes dos Santos Dias Marisa Spirandeli Crespi 《Journal of Thermal Analysis and Calorimetry》2010,102(3):1167-1173
Two ONNO type naphtaldehyde derivative Schiff base compounds were reduced and two symmetric phenol-amine ligands containing
naphthalene groups were obtained; bis-N,N′[(2-hydroxy-1-naphtyl) methyl]-1,3-propanediamine (NAFLH) and bis-N,N′[(2-hydroxy-1-naphtyl) methyl]-2,2′-dimetyhyl-1,3-propanediamine (NAFLDMH). Homotrinuclear Ni(II) complexes of these ligands were prepared. The solid-state molecular structures of representative
nickel complex of NAFLDMH were determined using single crystal X-ray diffraction analysis. The terminal Ni(II) ions were found to be situated in between
the donor atoms of the organic ligand. The central Ni(II) ion was observed to be bonded via two different μ-bridges. The phenolic
oxygens and carboxylate ion were seen to form two different μ-bridges. TG analysis proved that the compounds have different
thermal characteristics than those cited in literature. The complexes showed extreme exothermic degradation reactions in inert
atmosphere. The complexes are ruptured with a two stepped exothermic reaction which appears huge heat over 300 °C. The heat
appeared in O2 atmosphere is observed to be higher than the heat appeared in inert atmosphere. Revealed heat is observed to be higher than
the conventional explosive materials. 相似文献