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841.
Verdiana Covelli Manuela Grimaldi Rosario Randino Mohammad Firoznezhad Maria Chiara Proto Veronica De Simone Gianluca Matteoli Patrizia Gazzerro Maurizio Bifulco Anna Maria DUrsi Manuela Rodriquez 《Molecules (Basel, Switzerland)》2021,26(23)
N6-Isopentenyladenosine (i6A) is a naturally occurring modified nucleoside displaying in vitro and in vivo antiproliferative and pro-apoptotic properties. In our previous studies, including an in silico inverse virtual screening, NMR experiments and in vitro enzymatic assays, we demonstrated that i6A targeted farnesyl pyrophosphate synthase (FPPS), a key enzyme involved in the mevalonate (MVA) pathway and prenylation of downstream proteins, which are aberrant in several cancers. Following our interest in the anticancer effects of FPPS inhibition, we developed a panel of i6A derivatives bearing bulky aromatic moieties in the N6 position of adenosine. With the aim of clarifying molecular action of N6-benzyladenosine analogs on the FPPS enzyme inhibition and cellular toxicity and proliferation, herein we report the evaluation of the N6-benzyladenosine derivatives’ (compounds 2a–m) effects on cell viability and proliferation on HCT116, DLD-1 (human) and MC38 (murine) colorectal cancer cells (CRC). We found that compounds 2, 2a and 2c showed a persistent antiproliferative effect on human CRC lines and compound 2f exerted a significant effect in impairing the prenylation of RAS and Rap-1A proteins, confirming that the antitumor activity of 2f was related to the ability to inhibit FPPS activity. 相似文献
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844.
Manuela Ramos Silva Ana Matos Beja Jose Antonio Paixo Abilio J. F. N. Sobral Lucia M. L. Cabral A. M. d'A. Rocha Gonsalves 《Acta Crystallographica. Section C, Structural Chemistry》2003,59(10):o562-o563
Molecules of the title 2,5‐dioxopiperazinedione derivative, C8H10N2O6, occupy centres of symmetry in the crystal structure. The six‐membered ring has an almost planar conformation, with the substituent on nitrogen nearly perpendicular to the ring. The ideal geometry of the isolated molecule, as determined by ab initio HF–LCAO quantum‐mechanical calculations, is slightly more puckered than that observed in the solid state. In the crystal structure, a strong hydrogen bond joins neighbouring molecules, thus forming a network of rectangular (30) rings. 相似文献
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846.
David Welch Norman J. Kleiman Peter C. Arden Christine L. Kuryla Manuela Buonanno Brian Ponnaiya Xuefeng Wu David J. Brenner 《Photochemistry and photobiology》2023,99(1):168-175
Far-UVC radiation, typically defined as 200–235 nm, has similar or greater anti-microbial efficacy compared with conventional 254-nm germicidal radiation. In addition, biophysical considerations of the interaction of far-UVC with tissue, as well as multiple short-term safety studies in animal models and humans, suggest that far-UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long-term exposure to far-UVC has not been studied. Here, we assessed far-UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH-1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 400, 130 or 55 mJ cm−2 of 222 nm far-UVC radiation for 66 weeks, 5 days per week, 8 h per day, as well as similarly-treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths or incidental skin pathology findings was observed in the far-UVC-exposed mice. In addition, there were no significant changes in morbidity or mortality. The findings from this study support the long-term safety of long-term chronic exposure to far-UVC radiation, and therefore its potential suitability as a practical anti-microbial approach to reduce airborne viral and bacterial loads in occupied indoor settings. 相似文献
847.
Sebastiano Mantovani Angela Pintus Dr. Alessandro Kovtun Dr. Giulio Bertuzzi Dr. Manuela Melucci Prof. Marco Bandini 《European journal of organic chemistry》2023,26(37):e202300641
A new metal-free synthetic approach to functionalized indenes is documented. The use of commercially available graphene oxide (GO) allowed the direct access to indenyl cores (yield up to 80 %) via intramolecular Friedel-Crafts-type allylic alkylations with readily available Morita-Baylis-Hillman alcohols. Combined experimental and spectroscopic investigations contributed to shed light on the reaction mechanism dealing with a nanostructured carbon material-based C−C bond forming reaction. 相似文献
848.
Hermann Neitz Dr. Irene Bessi Valentin Kachler Manuela Michel Prof. Dr. Claudia Höbartner 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(1):e202214456
Arene-fluoroarene interactions offer outstanding possibilities for engineering of supramolecular systems, including nucleic acids. Here, we implement the tolane-perfluorotolane interaction as base pair replacement in DNA. Tolane (THH) and perfluorotolane (TFF) moieties were connected to acyclic backbone units, comprising glycol nucleic acid (GNA) or butyl nucleic acid (BuNA) building blocks, that were incorporated via phosphoramidite chemistry at opposite positions in a DNA duplex. Thermodynamic analyses by UV thermal melting revealed a compelling stabilization by THH/TFF heteropairs only when connected to the BuNA backbone, but not with the shorter GNA linker. Detailed NMR studies confirmed the preference of the BuNA backbone for enhanced polar π-stacking. This work defines how orthogonal supramolecular interactions can be tailored by small constitutional changes in the DNA backbone, and it inspires future studies of arene-fluoroarene-programmed assembly of DNA. 相似文献
849.
Non-isomorphic coupled cell networks with the same number of cells and with equivalent dynamics are said to be ODE-equivalent. Moreover, they are all related by a linear algebra condition involving their graph adjacency matrices. A network in an ODE-class is said to be minimal if it has a minimum number of edges among all the networks of the class. In this short paper we review the characterization of the minimal networks of an ODE-equivalence class and we present an example for the case of non-homogeneous networks. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
850.
Lisa Krapf Manuela Dezi Werner Reichstein Jürgen Köhler Silke Oellerich 《Colloids and surfaces. B, Biointerfaces》2011,82(1):25-32
We present a detailed AFM study on multilayered dry lipid films prepared from aqueous vesicle suspensions. Different preparation techniques were applied in order to optimize the preparation of homogeneous lipid films of various film thicknesses. Suspensions of preformed DOPC/DPPC vesicles were adsorbed onto indium tin oxide-coated glass coverslips, a substrate also commonly employed for the formation of giant liposomes. We found that the homogeneity of the lipid films could substantially be improved when applying a spin-coating step during the film preparation. These films were much more homogeneous than those prepared by conventional drop-casting and in addition the film thickness could be controlled. When using a combination of vesicle adsorption and spin-coating the quality and thickness of the films depended crucially on the lipid concentration of the vesicle suspension, the adsorption temperature and the adsorption time. For lipid films prepared by direct spin-coating the lipid concentration and the applied spin-coating sequence were critical parameters for the quality and thickness of the deposited lipid films. 相似文献