排序方式: 共有26条查询结果,搜索用时 15 毫秒
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F. Khuong-Huu D. Herlem-Gaulier MM. Qui Khuong-Huu E. Stanislas R. Goutarel 《Tetrahedron》1966,22(10):3321-3327
The following alkaloides have been extracted from the leaves of Buxus balearica Willd.: cyclomicrophylline-B, cycloprotobuxines A, C and D, baleabuxine (N-isobutyryl-baleabuxine-F), buxamine-E and buxaminol-E (already reported), N-isobutyryl- and N-benzoyl-baleabuxidine-F, baleabuxoxazine-C, N-isobutyryl- and N-benzoyl-baleabuxidienine-F, N-isobutyryl-baleabuxaline-F, the structures of which are proposed. The stereochemistry of baleabuxidines and baleabuxoxazines is established on the base of chemical correlations between these two groups and cyclomicrophyllines. 相似文献
24.
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Although a subject of intense research, the etiology of PD remains poorly understood. Recently, several lines of evidence have implicated an intimate link between aberrations in the ubiquitin proteasome system (UPS) and PD pathogenesis. Derangements of the UPS, which normally functions as a type of protein degradation machinery, lead to alterations in protein homeostasis that could conceivably promote the toxic accumulation of proteins detrimental to neuronal survival. Not surprisingly, various cellular and animal models of PD that are based on direct disruption of UPS function reproduce the most prominent features of PD. Although persuasive, new developments in the past few years have in fact raised serious questions about the link between the UPS and PD. Here I review current thoughts and controversies about their relationship and discuss whether strategies aimed at mitigating UPS dysfunction could represent rational ways to intervene in the disease. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com). 相似文献
25.
We report a generalization of our earlier formalism [Pramana, 54, 663 (1998)] to obtain exact solutions of Einstein-Maxwell’s equations for static spheres filled with a charged fluid having
anisotropic pressure and of null conductivity. Defining new variables: w=(4π/3)(ρ+ε)r
2, u=4πξr
2, v
r=4πp
r
r
2, v
⊥=4πp
⊥
r
2[ρ, ξ(=−(1/2)F
14
F
14), p
r, p
⊥ being respectively the energy densities of matter and electrostatic fields, radial and transverse fluid pressures whereas
ε denotes the eigenvalue of the conformal Weyl tensor and interpreted as the energy density of the free gravitational field],
we have recast Einstein’s field equations into a form easy to integrate. Since the system is underdetermined we make the following
assumptions to solve the field equations (i) u=v
r=(a
2/2κ)r
n+2, v
⊥=k
1
v
r, w=k
2
v
r; a
2, n(>0), k
1, k
2 being constants with κ=((k
1+2)/3+k
2) and (ii) w+u=(b
2/2)r
n+2, u=v
r, v
⊥−v
r=k, with b and k as constants. In both cases the field equations are integrated completely. The first solution is regular in the metric as
well as physical variables for all values of n>0. Even though the second solution contains terms like k/r
2 since Q(0)=0 it is argued that the pressure anisotropy, caused by the electric flux near the centre, can be made to vanish reducing
it to the generalized Cooperstock-de la Cruz solution given in [14]. The interior solutions are shown to match with the exterior
Reissner-Nordstrom solution over a fixed boundary.
Dedicated to Prof. F A E Pirani. 相似文献
26.
The problem considered is the fitting of a many-body interaction potential to bulk crystal data. A parameterisation of the
potential is assumed which is based on physical considerations. The free parameters are determined by using global optimization
to perform a least squares fit, to a large number of crystal properties. This has been achieved for body centered cubic (bcc)
materials. The approach adopted here fits the bcc crystal structure, as the preferred minimum energy configuration for tungsten,
and also fits the dimer energetics and the elastic properties of crystalline tungsten. 相似文献