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81.
T J Crevier B K Bennett J D Soper J A Bowman A Dehestani D A Hrovat S Lovell W Kaminsky J M Mayer 《Journal of the American Chemical Society》2001,123(6):1059-1071
The osmium(VI) nitrido complex TpOs(N)Cl(2) (1) has been prepared from K[Os(N)O(3)] and KTp in aqueous ethanolic HCl. It reacts rapidly with PhMgCl and related reagents with transfer of a phenyl group to the nitrido ligand. This forms Os(IV) metalla-analido complexes, which are readily protonated to give the analido complex TpOs(NHPh)Cl(2) (4). The nitrido-phenyl derivatives TpOs(N)PhCl and TpOs(N)Ph(2) react more slowly with PhMgCl and are not competent intermediates for the reaction of 1 with PhMgCl. Reactions of 1 with alkyl- and arylboranes similarly result in transfer of one organic group to nitrogen, leading to isolable borylamido complexes such as TpOs[N(Ph)(BPh(2))]Cl(2) (11). This is an unprecedented insertion of a nitrido ligand into a boron--carbon bond. Hydrolysis of 11 gives 4. Mechanistic studies suggest that both the Grignard and borane reactions proceed by initial weak coordination of Mg or B to the nitrido ligand, followed by migration of the carbanion to nitrogen. The hydrocarbyl group does not go to osmium and then move to nitrogen--there is no change in the atoms bound to the osmium during the reactions. It is suggested that there may be a general preference for nucleophiles to add directly to the metal--ligand multiple bond rather than binding to the metal first and migrating. Ab initio calculations show that the unusual reactivity of 1 results from its accessible LUMO and LUMO + 1, which are the Os = N pi* orbitals. The bonding in 1 and its reactivity with organoboranes are reminiscent of CO. 相似文献
82.
Routinely employed syntheses of terminally deuterated alkynes often utilize strong bases (i.e., LDA, n-BuLi, or Grignard reagents) or low (i.e., -78 °C) or elevated (i.e., 56 °C) reaction temperatures; furthermore many of these procedures afford average yields and in some cases less than optimum deuterium incorporation. Herein we report the application of alternative extremely mild reaction conditions that readily afford quantitative yields of terminally deuterated alkynes in a matter of minutes with exceptional isotope incorporation at ambient temperature. 相似文献
83.
The Fe(IV) d-d transition energies for four active-site structural models of class I ribonucleotide reductase (RNR) intermediate X have been calculated using broken-symmetry density functional theory incorporated with the Slater transition state vertical self-consistent reaction field methodology. Our model I (Figure 1), which contains two mu-oxo bridges, one terminal water, and one bidentate carboxylate group, yields the best Fe(IV) d-d transition energies compared with experiment. Our previous study (J. Am. Chem. Soc. 2005, 127, 15778-15790) also shows that most of the other calculated properties of model I in both native and mutant Y122F forms, including geometries, spin states, pKa's, 57Fe, 1H, and 17O hyperfine tensors, and 57Fe M?ssbauer isomer shifts and quadrupole splittings, are also the best in agreement with the available experimental data. This model is likely to represent the active-site structure of the intermediate state X of RNR. 相似文献
84.
Chen H Lyne PD Giordanetto F Lovell T Li J 《Journal of chemical information and modeling》2006,46(1):401-415
Four of the most well-known, commercially available docking programs, FlexX, GOLD, GLIDE, and ICM, have been examined for their ligand-docking and virtual-screening capabilities. The relative performance of the programs in reproducing the native ligand conformation from starting SMILES strings for 164 high-resolution protein-ligand complexes is presented and compared. Applying only the native scoring functions, the latest versions of these four docking programs were also used to conduct virtual screening for 12 protein targets of therapeutic interest, involving both publicly available structures and AstraZeneca in-house structures. The capability of the four programs to correctly rank-order target-specific active compounds over alternative binders and nonbinders (decoys plus randomly selected compounds) and thereby enrich a small subset of a screening library is compared. Enrichments from the virtual-screening experiments are contrasted with those obtained with alternative 3D shape-matching and 2D similarity database-search methods. 相似文献
85.
Vallotton P Sun C Lovell D Savelsbergh M Payne M Muench G 《Microscopy and microanalysis》2011,17(6):911-914
The detection of line-like features in images finds many applications in microanalysis. Actin fibers, microtubules, neurites, pilis, DNA, and other biological structures all come up as tenuous curved lines in microscopy images. A reliable tracing method that preserves the integrity and details of these structures is particularly important for quantitative analyses. We have developed a new image transform called the "Coalescing Shortest Path Image Transform" with very encouraging properties. Our scheme efficiently combines information from an extensive collection of shortest paths in the image to delineate even very weak linear features. 相似文献
86.
Lovell JF Chan MW Qi Q Chen J Zheng G 《Journal of the American Chemical Society》2011,133(46):18580-18582
Photodynamic therapy (PDT) stands to benefit from improved approaches to real-time treatment monitoring. One method is to use activatable photosensitizers that can both induce cell death (via singlet oxygen) and monitor it (via caspase detection). Here, we report porphyrins as caspase-responsive Forster Resonance Energy Transfer (FRET) acceptors to organic fluorophore donors. Compared to porphyrin FRET donor constructs, singlet oxygen generation was unquenched prior to caspase activation, resulting in more efficient photosensitization in HT-29 cancer cells. The donor 5-Carboxy-X-Rhodamine (Rox) formed a robust FRET pair with the pyropheophorbide (Pyro) acceptor. The large dynamic range of the construct enabled ratiometric imaging (with Rox excitation) of caspase activation in live, single cells following induction of cell death (with Pyro excitation) using a single agent. Quantitative, unquenched activatable photosensitizers (QUaPS) hold potential for new feedback-oriented PDT approaches. 相似文献
87.
88.
Cheol Park Jae‐Woo Kim Godfrey Sauti Jin Ho Kang Conrad S. Lovell Luke J. Gibbons Sharon E. Lowther Peter T. Lillehei Joycelyn S. Harrison Negin Nazem Larry T. Taylor 《Journal of Polymer Science.Polymer Physics》2012,50(6):394-402
Although many metal decorated nanotubes and nanowires appear in the literature, well‐dispersed metal decorated nanotube polymer composites have rarely been reported because of the excessive density mismatch between the decorated nanotubes and polymer matrix. Here, we report a novel method to prepare well‐dispersed, highly functional, metallized nanotube polymer composites (MNPCs) that possess remarkably improved electrical conductivity and mechanical toughness. The MNPCs are prepared by supercritical fluid impregnation of an organometal compound into a premade well‐dispersed single wall carbon nanotube‐polymer composite film. The infused precursor preferentially migrates towards the nanotubes to undergo spontaneous reduction and form nanometer‐scale metal particles leading to an increase in the conductivity of the MNPC films. The environmentally friendly supercritical fluid impregnation process significantly improved the toughness of the composite films, regardless of the presence of metal. Additional functionality can be imparted into the resulting MNPC by infusing other precursors such as magnetic and catalytic metal compounds. © 2011 Wiley Periodicals, Inc.* J Polym Sci Part B: Polym Phys, 2012 相似文献
89.
Jeffery B. Press Nancy H. Eudy F.M. Lovell Nancy A. Perkinson 《Tetrahedron letters》1980,21(18):1705-1708
8-Chloro-3,4-dihydro-5-(2-thienyl)-2H-1,6-benzothiazocine underwent a facile lead tetraacetate induced ring contraction forming several 3-(2-thienyl)-4H-1,4-benzothiazine derivatives. 相似文献
90.
Brines LM Shearer J Fender JK Schweitzer D Shoner SC Barnhart D Kaminsky W Lovell S Kovacs JA 《Inorganic chemistry》2007,46(22):9267-9277
A series of five-coordinate thiolate-ligated complexes [M(II)(tren)N4S(Me2)]+ (M = Mn, Fe, Co, Ni, Cu, Zn; tren = tris(2-aminoethyl)amine) are reported, and their structural, electronic, and magnetic properties are compared. Isolation of dimeric [Ni(II)(SN4(tren)-RS(dang))]2 ("dang"= dangling, uncoordinated thiolate supported by H bonds), using the less bulky [(tren)N4S](1-) ligand, pointed to the need for gem-dimethyls adjacent to the sulfur to sterically prevent dimerization. All of the gem-dimethyl derivatized complexes are monomeric and, with the exception of [Ni(II)(S(Me2)N4(tren)]+, are isostructural and adopt a tetragonally distorted trigonal bipyramidal geometry favored by ligand constraints. The nickel complex uniquely adopts an approximately ideal square pyramidal geometry and resembles the active site of Ni-superoxide dismutase (Ni-SOD). Even in coordinating solvents such as MeCN, only five-coordinate structures are observed. The MII-S thiolate bonds systematically decrease in length across the series (Mn-S > Fe-S > Co-S > Ni-S approximately Cu-S < Zn-S) with exceptions occurring upon the occupation of sigma* orbitals. The copper complex, [Cu(II)(S(Me2)N4(tren)]+, represents a rare example of a stable CuII-thiolate, and models the perturbed "green" copper site of nitrite reductase. In contrast to the intensely colored, low-spin Fe(III)-thiolates, the M(II)-thiolates described herein are colorless to moderately colored and high-spin (in cases where more than one spin-state is possible), reflecting the poorer energy match between the metal d- and sulfur orbitals upon reduction of the metal ion. As the d-orbitals drop in energy proceeding across the across the series M(2+) (M= Mn, Fe, Co, Ni, Cu), the sulfur-to-metal charge-transfer transition moves into the visible region, and the redox potentials cathodically shift. The reduced M(+1) oxidation state is only accessible with copper, and the more oxidized M(+4) oxidation state is only accessible for manganese. 相似文献