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排序方式: 共有817条查询结果,搜索用时 15 毫秒
21.
Highly ordered large pore SBA-15 silica functionalized with up to 16% aminopropyl groups, which gave high catalytic activity and selectivity toward flavanone synthesis through aldol condensation and subsequent intramolecular Michael addition of benzaldehyde and 2'-hydroxyacetophenone, was synthesized for the first time via co-condensation of tetraethylorthosilicate (TEOS) and 3-aminopropyltriethoxysilane (APTES) using an amphiphilic block copolymer as the structure-directing agent. 相似文献
22.
Bishop KJ Fiałkowski M Grzybowski BA 《Journal of the American Chemical Society》2005,127(45):15943-15948
Arrays of chemical oscillators are micropatterned by Wet Stamping. The technique is used to demonstrate that chemical waves can be initiated and controlled in oscillatory systems and that such waves can give rise to phenomena not observed in excitable media. Interoscillator coupling and synchronization, kinetic autofocusing, and twist-symmetry breaking are a consequence of the dependence of the oscillation phase on the local concentrations of reagents and on systems' geometry. Conditions under which a generic oscillatory system would exhibit such behaviors are determined. 相似文献
23.
This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a "molecular pegboard". We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations. 相似文献
24.
Using the electrochemical surface forces apparatus, we investigated adhesion (from pull-off measurements) between gold and mica as the potential of the gold surface was changed externally. Measurements were performed at different concentrations of KClO(4) in a potential window where the gold electrode is ideally polarizable. At applied potentials where the gold-mica interactions are repulsive, we obtain double layer forces that are predictable by the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory of colloid stability but deviate from the theory at short range. At applied potentials where the gold-mica interactions are attractive, we observed a very strong dependence of adhesion on the applied potential, a result that cannot be directly related to DLVO theory. We show, however, that an approach based on electrocapillary thermodynamics can be employed to model the potential dependence of adhesion seen in our measurements. This electrocapillary approach presents evidence of charging at the gold-mica interface and stresses the relation between the charge within and outside of the contact area. 相似文献
25.
Banerjee A Grewer C Ramakrishnan L Jäger J Gameiro A Breitinger HG Gee KR Carpenter BK Hess GP 《The Journal of organic chemistry》2003,68(22):8361-8367
The synthesis and characterization of a new photolabile protecting group (caging group) for carboxylic acids, the 2-(dimethylamino)-5-nitrophenyl (DANP) group, is described. This compound has a major absorption band in the visible wavelength region with a maximum near 400 nm (epsilon400 = 9077 M(-1) cm(-1) at pH 7.4 and 21 degrees C). The caging group is attached through an ester linkage to the carboxyl functionality of beta-alanine, which activates the inhibitory glycine receptor in the mammalian central nervous system. Such caged compounds play an important role in transient kinetic investigations of fast cellular processes. Upon photolysis of DANP-caged beta-alanine, the caging group is released within 5 micros. Quantum yields of 0.03 and 0.002 were obtained in the UV region (308 and 360 nm) and the visible region (450 nm), respectively. Laser-pulse photolysis experiments, using 337 or 360 nm light, were performed with the caged compound equilibrated with HEK 293 cells transiently transfected with cDNA encoding the alpha1 homomeric, wild-type glycine receptor. The experiments demonstrated that neither DANP-caged beta-alanine nor its byproducts inhibit or activate the glycine receptors on the cell surface. Under physiological conditions, the DANP-caged beta-alanine is water-soluble and stable and can be used for transient kinetic measurements. 相似文献
26.
Görgen JJ Comfort JR Tinsley JR Averett T DeKorse J Franklin B Ritchie BG Kyle G Klein A Berman B Burleson G Cranston K Faucett JA Jarmer JJ Knudson JN Penttilä S Tanaka N Brinkmöller B Dehnhard D Yen YF Hoibråten S Breuer H Flanders BS Khandaker MA Naples DL Zhang D Barlett ML Hoffmann GW Purcell M 《Physical review letters》1991,66(17):2193-2196
27.
Petrassi HM Johnson SM Purkey HE Chiang KP Walkup T Jiang X Powers ET Kelly JW 《Journal of the American Chemical Society》2005,127(18):6662-6671
Transthyretin (TTR) amyloidogenesis requires rate-limiting tetramer dissociation and partial monomer denaturation to produce a misassembly competent species. This process has been followed by turbidity to identify transthyretin amyloidogenesis inhibitors including dibenzofuran-4,6-dicarboxylic acid (1). An X-ray cocrystal structure of TTR.1(2) reveals that it only utilizes the outer portion of the two thyroxine binding pockets to bind to and inhibit TTR amyloidogenesis. Herein, structure-based design was employed to append aryl substituents at C1 of the dibenzofuran ring to complement the unused inner portion of the thyroxine binding pockets. Twenty-eight amyloidogenesis inhibitors of increased potency and dramatically increased plasma TTR binding selectivity resulted. These function by imposing kinetic stabilization on the native tetrameric structure of TTR, creating a barrier that is insurmountable under physiological conditions. Since kinetic stabilization of the TTR native state by interallelic trans suppression is known to ameliorate disease, there is reason to be optimistic that the dibenzofuran-based inhibitors will do the same. Preventing the onset of amyloidogenesis is the most conservative strategy to intervene clinically, as it remains unclear which of the TTR misassembly intermediates results in toxicity. The exceptional binding selectivity enables these inhibitors to occupy the thyroxine binding site(s) in a complex biological fluid such as blood plasma, required for inhibition of amyloidogenesis in humans. It is now established that the dibenzofuran-based amyloidogenesis inhibitors have high selectivity, affinity, and efficacy and are thus excellent candidates for further pharmacologic evaluation. 相似文献
28.
When bromoform (CHBr3) is photolyzed at 266 or 303 nm in the presence of O2 and NO, the formation of secondary Br atoms is observed. By following the rate of growth of this secondary Br atom signal as a function of conditions, rate constants have been determined for the reactions CHBr2 + O2, CHBr2 + NO (both pressure-dependent), and CHBr2O2 + NO (k(2a) = (1.74 +/- 0.16) x 10(-11) cm3 molecule(-1) s(-1) at 23 degrees C). By measuring the amplitude of the secondary Br signal compared to the primary Br formed in the initial photolysis, it is established that the CHBr2O radical spontaneously decomposes to form CHBrO + Br at least 90%, and probably 100%, of the time, in agreement with previous work and with recent ab initio calculations. A survey of four other polybrominated methanes, CH2Br2, CHClBr2, CF2Br2, and CBr4, shows that they all generate secondary Br atoms when photolyzed at 266 nm in the presence of O2 and NO, suggesting that their reaction sequences are similar to that of bromoform. 相似文献
29.
Kyle Clagg Sara Hold Archana Kumar Stefan G. Koenig Remy Angelaud 《Tetrahedron letters》2019,60(1):5-7
The direct application of Knochel-Hauser derivative arylmagnesium halides in Kumada-Corriu couplings is described. By utilizing the in situ-generated Grignard reagents, the transmetalation with stoichiometric zinc salts to known Negishi coupling conditions is avoided, thereby streamlining the transformation. Several aromatic hetereocycles participate in the deprotonation and couple with a variety of phenyl iodides and bromides in isolated yields up to 81%. The parent system is demonstrated on 6?g scale with 79% yield, and monitored via ReactIR to show the stability of the Grignard and progression of the deprotonation/CC coupling reaction. 相似文献
30.
Dimerization of Colloidal Particles through Controlled Aggregation for Enhanced Properties and Applications 下载免费PDF全文
Devising syntheses capable of precisely manipulating matter on the nanoscale is central to many areas of research. The underlying motivation is fueled by the fact that at the nanometer scale, the property has a strong correlation with the structure. One such nanostructure that has accrued much attention is the dimer—a structure composed of two colloidal particles separated by a small gap. This Focus Review discusses how colloidal stability can be strategically manipulated to induce dimerization, together with effective purification steps to further improve yields. We conclude the article by providing representative examples for how dimers composed of plasmonic nanoparticles leads to structures with tunable optical properties and strong electric near‐fields, ideal for application in surface‐enhanced Raman spectroscopy. 相似文献