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排序方式: 共有173条查询结果,搜索用时 437 毫秒
101.
C Elberling M Don SG Kristensen 《The Journal of the Acoustical Society of America》2012,132(2):EL149-EL154
Recently it has been demonstrated that auditory brainstem responses, ABRs, to chirps are larger with the ER-2 than with the ER-3A insert earphone due to differences between the corresponding amplitude-frequency responses. Therefore a modified chirp, which equalizes the amplitude-frequency response of the ER-3A, is constructed and subsequently compared to the unmodified chirp. ABRs are recorded from 20 normal-hearing subjects in response to the two chirps delivered by the ER-3A earphone at a wide range of levels. The results confirm that the modified chirp generates significantly larger ABRs than the unmodified chirp at levels below 60?dB nHL. 相似文献
102.
Kristensen TG Nielsen J Pedersen CN 《Journal of chemical information and modeling》2011,51(3):597-600
The ever growing size of chemical databases calls for the development of novel methods for representing and comparing molecules. One such method called LINGO is based on fragmenting the SMILES string representation of molecules. Comparison of molecules can then be performed by calculating the Tanimoto coefficient, which is called LINGOsim when used on LINGO multisets. This paper introduces a verbose representation for storing LINGO multisets, which makes it possible to transform them into sparse fingerprints such that fingerprint data structures and algorithms can be used to accelerate queries. The previous best method for rapidly calculating the LINGOsim similarity matrix required specialized hardware to yield a significant speedup over existing methods. By representing LINGO multisets in the verbose representation and using inverted indices, it is possible to calculate LINGOsim similarity matrices roughly 2.6 times faster than existing methods without relying on specialized hardware. 相似文献
103.
This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively. 相似文献
104.
Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases 下载免费PDF全文
Dr. Astrid Knuhtsen Dr. Baptiste Legrand Olivier Van der Poorten Prof. Muriel Amblard Prof. Jean Martinez Prof. Steven Ballet Prof. Jesper L. Kristensen Prof. Daniel Sejer Pedersen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(39):14022-14028
Protein arginine N‐methyl transferases (PRMTs) belong to a family of enzymes that modulate the epigenetic code through modifications of histones. In the present study, peptides emerging from a phage display screening were modified in the search for PRMT inhibitors through substitution with non‐proteinogenic amino acids, N‐alkylation of the peptide backbone, and incorporation of constrained dipeptide mimics. One of the modified peptides ( 23 ) showed an increased inhibitory activity towards several PRMTs in the low μm range and the conformational preference of this peptide was investigated and compared with the original hit using circular dichroism and NMR spectroscopy. Introducing two constrained tryptophan residue mimics (l ‐Aia) spaced by a single amino acid was found to induce a unique turn structure stabilized by a hydrogen bond and aromatic π‐stacking interaction between the two l ‐Aia residues. 相似文献
105.
Tervo OM Christoffersen MF Parks SE Kristensen RM Madsen PT 《The Journal of the Acoustical Society of America》2011,130(4):2257-2262
Simultaneous production of two harmonically independent sounds, the two-voice phenomenon, is a well-known feature in bird song. Some toothed whales can click and whistle simultaneously, and a few studies have also reported simultaneous sound production by baleen whales. The mechanism for sound production in toothed whales has been largely uncovered within the last three decades, whereas mechanism for sound production in baleen whales remains poorly understood. This study provides three lines of evidence from recordings made in 2008 and 2009 in Disko Bay, Western Greenland, strongly indicating that bowhead whales are capable of simultaneous dual frequency sound production. This capability may function to enable more complex singing in an acoustically mediated reproductive advertisement display, as has been suggested for songbirds, and/or have significance in individual recognition. 相似文献
106.
To develop an efficient green extraction approach for recovery of bioactive compounds from natural plants, we examined the potential of pressurized liquid extraction (PLE) of ginger (Zingiber officinale Roscoe) with bioethanol/water as solvents. The advantages of PLE over other extraction approaches, in addition to reduced time/solvent cost, the extract of PLE showed a distinct constituent profile from that of Soxhlet extraction, with significantly improved recovery of diarylheptanoids, etc. Among the pure solvents tested for PLE, bioethanol yield the highest efficiency for recovering most constituents of gingerol-related compounds; while for a broad concentration spectrum of ethanol aqueous solutions, 70% ethanol gave the best performance in terms of yield of total extract, complete constituent profile and recovery of most gingerol-related components. PLE with 70% bioethanol operated at 1500 psi and 100 °C for 20 min (static extraction time: 5 min) is recommended as optimized extraction conditions, achieving 106.8%, 109.3% and 108.0% yield of [6]-, [8]- and [10]-gingerol relative to the yield of corresponding constituent obtained by 8h Soxhlet extraction (absolute ethanol as extraction solvent). 相似文献
107.
In this paper a new tool for simultaneous optimisation of decisions on multiple time scales is presented. The tool combines the dynamic properties of Markov decision processes with the flexible and compact state space representation of LImited Memory Influence Diagrams (Limids). A temporal version of Limids, TemLimids, is defined by adding time-related functions to utility nodes. As a result, expected discounted utility, as well as expected relative utility might be used as optimisation criteria in TemLimids. Optimisation proceeds as in ordinary Limids. A sequence of such TemLimids can be used to model a Markov Limid Process, where each TemLimid represents a macro action. Algorithms are presented to find optimal plans for a sequence of such macro actions. Use of algorithms is illustrated based on an extended version of an example from pig production originally used to introduce the Limid concept. 相似文献
108.
Lan Ge Anders R. Kristensen Monique C. Mourits Ruud B. Huirne 《Annals of Operations Research》2014,219(1):49-62
Animal disease epidemics such as the foot-and-mouth disease (FMD) pose recurrent threat to countries with intensive livestock production. Efficient FMD control is crucial in limiting the damage of FMD epidemics and securing food production. Decision making in FMD control involves a hierarchy of decisions made at strategic, tactical, and operational levels. These decisions are interdependent and have to be made under uncertainty about future development of the epidemic. Addressing this decision problem, this paper presents a new decision-support framework based on multi-level hierarchic Markov processes (MLHMP). The MLHMP model simultaneously optimizes decisions at strategic, tactical, and operational levels, using Bayesian forecasting methods to model uncertainty and learning about the epidemic. As illustrated by the example, the framework is especially useful in contingency planning for future FMD epidemics. 相似文献
109.
Ida-Marie Høyvik Kasper Kristensen Thomas Kjærgaard Poul Jørgensen 《Theoretical chemistry accounts》2014,133(1):1-10
A common perception about molecular systems with a nonlocal electronic structure (as manifested by a nonlocal Hartree–Fock (HF) density matrix), such as conjugated π-systems, is that they can only be described in terms of nonlocal molecular orbitals. This view is mostly founded on chemical intuition, and further, this view is strengthened by traditional approaches for obtaining local occupied and virtual orbital spaces, such as the occupied Pipek–Mezey orbitals, and projected atomic orbitals. In this article, we discuss the limitations for localizability of HF orbitals in terms of restrictions posed by the delocalized character of the underlying density matrix for the molecular system and by the orthogonality constraint on the molecular orbitals. We show that the locality of the orbitals, in terms of nonvanishing charge distributions of orbitals centered far apart, is much more strongly affected by the orthogonality constraint than by the physical requirement that the occupied orbitals must represent the electron density. Thus, the freedom of carrying out unitary transformations among the orbitals provides the flexibility to obtain highly local occupied and virtual molecular orbitals, even for molecular systems with a nonlocal density matrix, provided that a proper localization function is used. As an additional consideration, we clear up the common misconception that projected atomic orbitals in general are more local than localized orthogonal virtual orbitals. 相似文献
110.
Zuzana Valnickova Morten Thaysen-Andersen Peter Højrup Trine Christensen Kristian W Sanggaard Torsten Kristensen Jan J Enghild 《BMC biochemistry》2009,10(1):13-15