Mass spectrometry of organic compounds of the group V elements: V-Cyanamides,cyanphosphines, cyanarsines and vinylogues

New data have been obtained confirming distinct differences in fragmentation of compounds of trivalent nitrogen and other group V elements under electron impact. These data have been obtained for the fragmentation of the cyanamides, cyanphosphines and cyanarsines, as well as of their vinylogues.     

Cyclic hydroxamic acids derived from α-amino acids 2. Regioselective synthesis,crystal structure,and antitumor activity of spiropiperidine-imidazolidine hydroxamic acids based on glycine and dl-alanine

Regioselective cyclocondensation of glycine hydroxamic and dl-alanine hydroxamic acids with 1-methylpiperidin-4-one gave 1-hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one (5) and (±)-1-hydroxy-3,8-dimethyl-1,4,8-triazaspiro[4.5]decan-2-one (6), respectively. The X-ray diffraction data showed that acid 6 formed racemic crystals with two independent molecules, whose structure was studied and compared with the analog obtained earlier. The in vivo tests on the leukemia P388 and L1210 models showed that the low-toxic spirocyclic hydroxamic acids 5 and 6 were the adjuvants of clinic cytostatics cisplatin and cyclophosphamide. Chemotherapy of the leukemias P388 and L1210 was more efficient with the combination of acid 6 with cisplatin and cyclophosphamide, respectively.     

Asymmetrical nonbridgehead nitrogen—IV : Chiroptical properties of the amines,N-chloroamines and cyanamides

The ORD and CD spectra of 2-methyl-aziridine, azetidine, pyrrolidine, piperidine, their N-Me, N-Hal, N-CN derivatives as well as those of camphidine, N-methyl- and N-cyano-camphidine have been investigated. The possibility of application of the quadrant rule for N-chloroamines is discussed. A similar rule is proposed for the N-CN chromophore.