医药类专业物理课程教学存在的问题及对策

根据对国内69所普通高等院校医药类专业（本科）物理课程教学现状调查的结果,分析了在我国高等教育进入“大众化教育”的形势下,医药类专业物理课程教学中存在的4个急需解决的问题,指出了医药类专业物理课程教学改革的方向,并介绍了我们所做的一些工作。     

Lattice Boltzmann study of multi-walled carbon nanotube (MWCNT)-Fe3O4/water hybrid nanofluids natural convection heat transfer in a Π-shaped cavity equipped by hot obstacle

In the present paper, the effect of nanofluid and the hot obstacle in a Π-shaped cavity is investigated. Lattice Boltzmann method is used to simulate the fluid flow and heat transfer. The effects of the parameters such as the nanoparticle solid volume fraction, the Rayleigh number, aspect ratio of cavity and hot obstacle position on the flow pattern and heat transfer parameters are studied. The numerical results are compared with previous results for validation, and a good agreement obtained. It is found that the average Nusselt number is increased by increasing the nanoparticle solid volume fraction, the Rayleigh number and the aspect ratio of cavity. Moreover, the effect of Rayleigh number on the average Nusselt number at high Rayleigh numbers (10⁵–10⁶) is more pronounced than that at low Rayleigh numbers (10³–10⁴) due to the different heat transfer mechanisms. The position of the hot obstacle affects the heat transfer significantly. When the hot obstacle is located on the center, the heat transfer is more effective.

     

Biochemical studies on oral toxicity of ricin. V. The role of lectin activity in the intestinal absorption of ricin.

In order to investigate a possible role of lectin activity of ricin in its absorption from the small intestine, we prepared two ricin derivatives. BMH-ricin, prepared by crosslinking A and B chains of ricin with 1,6-bismaleimidohexane, was nearly non-toxic but the lectin activity was unaltered. And, NBS-ricin, prepared by the oxidation of tryptophanyl residues of ricin with N-bromosuccinimide, was not only non-toxic but also non-lectinic. After the oral administration of ricin derivatives to rats, their interaction with the digestive tract and absorption into the circulatory systems have been compared with those of ricin, immunochemically and histologically. It was shown by immunostaining that ricin and BMH-ricin could bind to the intestinal mucosa, whereas NBS-ricin could not. No appreciable damage in the small intestine from rats treated with either BMH-ricin or NBS-ricin has been observed, in contrast to ricin treatment where severe impairment of the small intestinal tissues resulted after 5 h. Immunoreactive ricin in the liver has been determined with the ricin enzyme immunoassay (EIA). When compared at 48 h after oral administration, NBS-ricin was not detected, whereas BMH-ricin was found to be 38 micrograms/liver and ricin 100 micrograms/liver. From these results, it was inferred that the lectin activity of ricin plays an important role in the absorption of ricin from the small intestine and that the absorption of ricin protein was enhanced by its high toxicity.