Un analogue local du théorème de Harnack

Sans résumé     

Synthesis of 3′-deoxy-3′-iminodiacetic acid and 3′-deoxy-3′-aminodiethanol thymidine analogues and NMR study of their complexation with boronic acids

The iminodiacetic acid and aminodiethanol moieties are known for their ability to generate with boronic acids bicyclic structures having a strong intramolecular NB coordination. We describe here the convergent synthesis of 3′-deoxy-3′-iminodiacetic acid and 3′-deoxy-3′-aminodiethanol thymidine analogues. The abilities of these compounds to form boronate complexes with aliphatic or aromatic boronic acids were established by 1D and 2D ¹H and ¹³C NMR. Moreover, conformational analysis of the newly synthesized compounds revealed a marked preference for an N-type sugar puckering.     

Analytical investigation of Bénard-Marangoni convection heat transfer in a shallow cavity filled with two immiscible fluids

The mechanism of natural and Marangoni convection in a system with two stratified fluid layers without mass transfer at the interface is investigated. The basis of the analytical solution is an assumption of parallel flow over a large portion of the system. The two cases of heat fluxes through horizontal or vertical opposite walls are considered. It is demonstrated that four different patterns of convection can be observed in the present system. The zone of occurrence of these flow patterns are specified in terms of non-dimensional parameters. Velocity and temperature distributions, stream function and Nusselt number are presented over a wide range of the governing parameters. The results obtained are explained in terms of the basic physical mechanisms that govern these flows showing many interesting aspects of the complex interaction between the buoyant and surface tension mechanisms.     

Analytical and numerical study of natural convection heat transfer in an inclined composite enclosure

Laminar natural convection heat transfer in inclined fluid layers divided by a partition with finite thickness and conductivity is studied analytically and numerically. The governing equations for the fluid layers are solved analytically in the limit of a thin layered system with constant flux boundary conditions. The study covers of the range of Ra from 10³ to 10⁷, from 0° to 180° and the thermal conductivity ratio of partition to fluid ratioK from 10^–2 to 10⁶. The Prandtl number was 0.72 (for air). Results are obtained in terms of an overall Nusselt number as a function of Rayleigh number, angle of inclination of the system, mid layer thickness, and mid layer thermal conductivity. The critical Rayleigh number for the onset of convection in a bottom-heated horizontal system is predicted. The results are compared with the numerical results obtained by solving the complete system of governing equations, using SIMPLER method, as well as with the limiting cases in the literature.     

Synthesis of the trans-fusarinine scaffold

The trans-fusarinine backbone is a common feature encountered in many fungal siderophores. This monomer is notably the structural base of N^α-methyl coprogen B and dimerumic acid. Both siderophores are known to be secreted by Scedosporium apiospermum, an emerging pathogenic fungus studied for its high involvement in invasive infections of immunocompromised patients. The strategy developed here for the synthesis of the trans-fusarinine scaffold relies on the preparation of both N-hydroxyornithine and 3-anhydroxymevalonic acid subunits starting from l-ornithine and 3-butyn-1-ol, respectively. The coupling of these two building blocks led to the expected protected backbone.     

Improved and isotropic resolution in tomographic diffractive microscopy combining sample and illumination rotation

Tomographic Diffractive Microscopy is a technique, which permits to image transparent living specimens in three dimensions without staining. It is commonly implemented in two configurations, by either rotating the sample illumination keeping the specimen fixed, or by rotating the sample using a fixed illumination. Under the first-order Born approximation, the volume of the frequency domain that can be mapped with the rotating illumination method has the shape of a “doughnut”, which exhibits a so-called “missing cone” of non-captured frequencies, responsible for the strong resolution anisotropy characteristic of transmission microscopes. When rotating the sample, the resolution is almost isotropic, but the set of captured frequencies still exhibits a missing part, the shape of which resembles that of an apple core. Furthermore, its maximal extension is reduced compared to tomography with rotating illumination. We propose various configurations for tomographic diffractive microscopy, which combine both approaches, and aim at obtaining a high and isotropic resolution. We illustrate with simulations the expected imaging performances of these configurations.     

A new proof of partial regularity of solutions to Navier-Stokes equations

In this paper we give a new proof of the partial regularity of solutions to the incompressible Navier-Stokes equation in dimension 3 first proved by Caffarelli, Kohn and Nirenberg. The proof relies on a method introduced by De Giorgi for elliptic equations. This work was supported in part by NSF Grant DMS-0607953.     

Multigrid preconditioned Krylov subspace methods for three-dimensional numerical solutions of the incompressible Navier–Stokes equations

We consider numerical methods for the incompressible Reynolds averaged Navier–Stokes equations discretized by finite difference techniques on non-staggered grids in body-fitted coordinates. A segregated approach is used to solve the pressure–velocity coupling problem. Several iterative pressure linear solvers including Krylov subspace and multigrid methods and their combination have been developed to compare the efficiency of each method and to design a robust solver. Three-dimensional numerical experiments carried out on scalar and vector machines and performed on different fluid flow problems show that a combination of multigrid and Krylov subspace methods is a robust and efficient pressure solver. This revised version was published online in June 2006 with corrections to the Cover Date.