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161.
Maksimoska J Feng L Harms K Yi C Kissil J Marmorstein R Meggers E 《Journal of the American Chemical Society》2008,130(47):15764-15765
A strategy for targeting protein kinases with large ATP-binding sites by using bulky and rigid octahedral ruthenium complexes as structural scaffolds is presented. A highly potent and selective GSK3 and Pim1 half-sandwich complex NP309 was successfully converted into a PAK1 inhibitor by making use of the large octahedral compounds Lambda-FL172 and Lambda-FL411 in which the cyclopentadienyl moiety of NP309 is replaced by a chloride and sterically demanding diimine ligands. A 1.65 A cocrystal structure of PAK1 with Lambda-FL172 reveals how the large coordination sphere of the ruthenium complex matches the size of the active site and serves as a yardstick to discriminate between otherwise closely related binding sites. 相似文献
162.
163.
Electrochemical oxidation of (?)‐epigallocatechin gallate (EGCG), the main monomer flavanol found in green tea, has been investigated over a wide pH range at a glassy‐carbon electrode using square‐wave voltammetry (SWV). Square‐wave voltammograms of (?)‐epigallocatechin (EGC) and gallic acid have been studied as well. The I–E profile of EGCG, i.e. the oxidation potentials and the current responses of the first and the second peak, is pH dependent. The oxidation of EGCG is a quasireversible process over the studied pH range, which was also confirmed by the non‐linear relationship between the peak currents and squre root of frequency. The best SWV responses for EGCG were obtained at pH 2.0, frequency of 100 Hz, step of 2 mV and amplitude of 50 mV. Under these conditions, linear responses for EGCG were obtained for concentrations from 1×10?7 M to 1×10?6 M, and calculated LOD and LOQ for the first oxidation peak were 6.59×10?8 M and 2.19×10?7 M, respectively. The proposed electroanalytical procedure was applied for the determination of EGCG content in green tea. Developed SWV methodology represents a potential analytical tool in determination of catechins in tea samples. 相似文献
164.