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31.
潘强岩 M.DE Poli G.De Angelis C.Fahander D.Bazzacco E.Farnea A.Gadea D.R.Napoli P.Spolaore 《原子核物理评论》1997,14(4):218-221
通过55Mn(30Si,αpn)反应布居了79Kr的高自旋态.用GASP阵列配以由40个ΔE×ESi(Au)望远镜所组成的带电粒子球实现γγγ-带电粒子符合测量.观测到由相对强度为(2.7±0.3)%的8条级联γ跃迁所组成的79Kr高自旋超形变转动带.除了在转动频率ω>0.95MeV处急剧下降外,该带的动力学转动惯量近乎常数(22ñ2/MeV)并被解释为具有四极形变参数β2=0.51以及本征侵入组态为π50ν51. High-spinstates in 79Kr were populated via the fusion evaporation reaction 55Mn (30Si,αpn)at 130 MeV.Promptγ γγ charged particle coincidences were measured by using the GASP array in conjunction with the ΔE×E Si(Au) charged particle ball.Asu perdeformed band consisting of 8 γ ray transitions with an intensity of (2.7±0.3)% has been indentified in 79Kr.The dynamic moment of inertia for the band is nearly constant at approxately 22ñ2/MeV below arotational frequency of 0.95 MeV... 相似文献
32.
文献中已有越来越多的芳香性体系被发现,同时也有越来越多的芳香性指标被提出来,但是如何解释芳香化合物稳定性的起源以及理解芳香性的本质仍然是当今理论化学中一个悬而未决的难题。运用我们新近提出的密度泛函活性理论信息论方法,不久前我们曾对一系列富烯衍生物进行了系统研究并得到了一个全新的认识。本文进一步探讨苯并富烯衍生物的芳香性行为,目的在于考察一个或多个苯环与富烯连接之后其芳香性发生变化的情况。运用香农熵,费舍尔信息,Ghosh-Berkowitz-Parr熵,Onicescu信息能,信息增益,以及相对Rényi熵六个信息量,和四种芳香指标,ASE,HOMA,FLU和NICS,我们系统地研究了信息量和芳香性指标在单、双、三苯并富烯衍生物中的相关性。我们发现,不管是否有苯环与富烯相连,芳香指标和信息量的交叉相关性都是一样的。这表明,虽然苯环本身具有芳香性,但苯环与富烯相连并不能改变富烯的芳香性与反芳香性本质。苯并富烯衍生物与富烯衍生物的芳香性和反芳香性一致。苯并富烯衍生物的芳香性和反芳香性完全取决于富烯本身的芳香性和反芳香性。这些结果为认识和理解复杂体系芳香性和反芳香性起源和本质将提供有益的启示。 相似文献
33.
34.
A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells 总被引:2,自引:0,他引:2
Here we describe a combined microfluidic-micromagnetic cell separation device that has been developed to isolate, detect and culture circulating tumor cells (CTCs) from whole blood, and demonstrate its utility using blood from mammary cancer-bearing mice. The device was fabricated from polydimethylsiloxane and contains a microfluidic architecture with a main channel and redundant 'double collection' channel lined by two rows of dead-end side chambers for tumor cell collection. The microdevice design was optimized using computational simulation to determine dimensions, magnetic forces and flow rates for cell isolation using epithelial cell adhesion molecule (EpCAM) antibody-coated magnetic microbeads (2.8 μm diameter). Using this device, isolation efficiencies increased in a linear manner and reached efficiencies close to 90% when only 2 to 80 breast cancer cells were spiked into a small volume (1.0 mL) of blood taken from wild type mice. The high sensitivity visualization capabilities of the device also allowed detection of a single cell within one of its dead-end side chambers. When blood was removed from FVB C3(1)-SV40 T-antigen mammary tumor-bearing transgenic mice at different stages of tumor progression, cells isolated in the device using anti-EpCAM-beads and magnetically collected within the dead-end side chambers, also stained positive for pan-cytokeratin-FITC and DAPI, negative for CD45-PerCP, and expressed SV40 large T antigen, thus confirming their identity as CTCs. Using this isolation approach, we detected a time-dependent rise in the number of CTCs in blood of female transgenic mice, with a dramatic increase in the numbers of metastatic tumor cells appearing in the blood after 20 weeks when tumors transition to invasive carcinoma and exhibit increased growth of metastases in this model. Importantly, in contrast to previously described CTC isolation methods, breast tumor cells collected from a small volume of blood removed from a breast tumor-bearing animal remain viable and they can be easily removed from these devices and expanded in culture for additional analytical studies or potential drug sensitivity testing. 相似文献
35.
Development of an in vitro living cell-based model of the intestine that mimics the mechanical, structural, absorptive, transport and pathophysiological properties of the human gut along with its crucial microbial symbionts could accelerate pharmaceutical development, and potentially replace animal testing. Here, we describe a biomimetic 'human gut-on-a-chip' microdevice composed of two microfluidic channels separated by a porous flexible membrane coated with extracellular matrix (ECM) and lined by human intestinal epithelial (Caco-2) cells that mimics the complex structure and physiology of living intestine. The gut microenvironment is recreated by flowing fluid at a low rate (30 μL h(-1)) producing low shear stress (0.02 dyne cm(-2)) over the microchannels, and by exerting cyclic strain (10%; 0.15 Hz) that mimics physiological peristaltic motions. Under these conditions, a columnar epithelium develops that polarizes rapidly, spontaneously grows into folds that recapitulate the structure of intestinal villi, and forms a high integrity barrier to small molecules that better mimics whole intestine than cells in cultured in static Transwell models. In addition, a normal intestinal microbe (Lactobacillus rhamnosus GG) can be successfully co-cultured for extended periods (>1 week) on the luminal surface of the cultured epithelium without compromising epithelial cell viability, and this actually improves barrier function as previously observed in humans. Thus, this gut-on-a-chip recapitulates multiple dynamic physical and functional features of human intestine that are critical for its function within a controlled microfluidic environment that is amenable for transport, absorption, and toxicity studies, and hence it should have great value for drug testing as well as development of novel intestinal disease models. 相似文献
36.
用真空电弧熔炼法制备了Ce2Co17-xMx(M=Ga,Al和Si)化合物。通过X射线衍射和磁性测量手段,研究了非磁性替代原子Ga,Al和Si的加入对Ce2Co17化合物的剧里温度和饱和磁化强度的影响,其中Si在Ce2Co17化合物中的固溶度最小,并使居里温度和饱和磁化强度下降幅度最大。 相似文献
37.
The flow about submerged, fully cavitating axisymmetric bodies at both zero and non-zero angle of attack is considered in this paper. A cavity closure model that relates the point of detachment, the angle that the separating streamline makes with the body and the cavity length is described. The direct boundary element method is used to solve the potential flow problem and to determine the cavity shape. A momentum integral boundary layer solver is included in the formulation so that shear stresses can be incorporated into the drag calculations. The numerical predictions based on the proposed closure model are compared with water tunnel measurements and photographs. 相似文献
38.
本文考虑广义BBM方程的初值问题,建立了方程的有理Chebyshev谱格式,给出了谱格式的误差估计,并证明了原问题和近似问题所生成的算子半群分别具有整体吸引子A和AN,且AN关于A 是上半连续的. 相似文献
39.
Time integration of the non-linear Galerkin method 总被引:1,自引:0,他引:1
e-mail: bosco{at}mac.cie.uva.es, frutos@mac.cie.uva.es Numerical tests are presented that, for the Kuramoto-Sivashinskyand a reaction-diffusion equation, compare the non-linear Galerkinmethod with standard pseudospectral and pure spectral Galerkindiscretizations. The results show that, for these problems,the non-linear Galerkin method is not competitive with eitherpure spectral Galerkin or pseudospectral discretizations. 相似文献
40.
RIVERA JAIME E. MU$$$OZ; DE LACERDA OLIVEIRA MILTON 《IMA Journal of Applied Mathematics》1997,58(1):71-82
We consider the unilateral problem for the thermoelastic equationand we show that the solution decays exponentially to zero astime goes to infinity; that is, denoting by E(t) the first-orderenergy of the system, we show that positive constants C and exist which satisfy E(t)CE(0)e$$$. 相似文献