Dynamical effects of QCD in q2$ \bar{{q}}^{{2}}_{}$ systems

We study the coupling of a tetraquark system to an exchanged meson-meson channel, using a pure gluonic theory based four-quark potential matrix model which is known to fit well a large number of data points for lattice simulations of different geometries of a four-quark system. We find that if this minimal-area-based potential matrix replaces the earlier used simple Gaussian form for the gluon field overlap factor f in its off-diagonal terms, the resulting T -matrix and phase shifts develop an angle dependence whose partial-wave analysis reveals D wave and higher angular-momentum components in it. In addition to the obvious implications of this result for the meson-meson scattering, this new feature indicates the possibility of orbital excitations influencing properties of meson-meson molecules through a polarization potential. We have used a formalism of the resonating group method, treated kinetic energy and overlap matrices on model of the potential matrix, but decoupled the resulting complicated integral equations through the Born approximation. In this exploratory study we have used a quadratic confinement and not included the spin dependence; we also used the approximation of equal constituent quark masses.     

Thermal characterization of Se85−xSb15Snx (10≤x≤13) chalcogenide glasses

Results of crystallization kinetics, viscosity, specific heat, thermal stability, and glass forming ability of Se_85−xSb₁₅Sn_x (x=10, 11, 12.5, and 13) chalcogenide glasses, using differential scanning calorimeter (DSC), under non-isothermal condition have been reported and discussed. The variation of the peak temperature of crystallization T_p with the heating rate β has been used to investigate the growth kinetics using Kissinger, Takhor, and Augis-Bennet models. The activation energy of crystallization E_c has been found to increase with Sn content and the crystal growth occurs in one dimension. The increasing trend of E_c is interpreted in terms of enhancement of the degree of cross-linking due to the formation of SnSe_4/2 structural units of energies higher than that of Se-Se and Se-Sb bond energies. The viscosity η against 1/T curves has also been drawn and indicated that the atoms of ternary Se-Sb-Sn glasses required more energy, with the addition of Sn, to complete the transformation from amorphous to crystalline state. The demand for thermal stability has been ensured through the calculations of the enthalpy released ΔH_c during the crystallization process and S-parameter, while the obtained values of the reduced glass transition temperature T_rg and Hurby number H_R have been used to estimate the glass forming ability (GFA). Results reveal that, both thermal stability and GFA enhanced with increasing Sn content and the studied samples were prepared from strong glass-forming liquids. The obtained values for the specific heat difference ΔC_p, between the equilibrium liquid and the glass, have been found to decrease with increasing Sn content and are in support of the results of thermal stability and GFA.     

On the Constant Metric Dimension of Generalized Petersen Graphs P（n, 4）

In this paper,we consider the family of generalized Petersen graphs P(n,4).We prove that the metric dimension of P(n,4) is 3 when n ≡ 0(mod 4),and is 4 when n = 4k + 3(k is even).For n ≡ 1,2(mod 4) and n = 4k + 3(k is odd),we prove that the metric dimension of P(n,4) is bounded above by 4.This shows that each graph of the family of generalized Petersen graphs P(n,4)has constant metric dimension.     

On topological properties of poly honeycomb networks

Topological indices are numerical parameters of a graph which characterize its topology and are usually graph invariant. In QSAR/QSPR study, physico-chemical properties and topological indices such as the Randi?, the atom-bond connectivity (ABC) and the geometric-arithmetic (GA) indices are used to predict the bioactivity of chemical compounds. Graph theory has found a considerable use in this area of research. In this paper, we study poly honeycomb networks which are generated by a honeycomb network of dimension n and derive analytical closed results for the general Randi? index \(R_\alpha (G)\) for different values of \(\alpha \), for a David derived network \((\textit{DD}(n))\) of dimension n, a dominating David derived network \((\textit{DDD}(n))\) of dimension n as well as a regular triangulene silicate network of dimension n. We also compute the general first Zagreb, ABC, GA, \(\textit{ABC}_4\) and \(\textit{GA}_5\) indices for these poly honeycomb networks for the first time and give closed formulas of these degree based indices in case of poly honeycomb networks.     

Ailanthus altissima (Miller) Swingle fruit - new acyl β-sitosteryl glucoside and in vitro pharmacological evaluation

β-Sitosterol-3-O-(6?-O-13?-octadecenoyl)-β-D-glucoside (1), a new acyl β-sitosteryl glucoside, along with three known compounds β-sitosterol-3-O-β-D-glucoside (2), β-sitosterol (3) and methyl gallate (4) have been isolated from the ethyl acetate soluble fraction of methanolic extract of Ailanthus altissima fruits. Their structures were elucidated through spectroscopic data including 2D NMR, ESI-MS, methanolysis and oxidative cleavage of double bond. Antibacterial, antifungal, cytotoxic, phytotoxic and insecticidal activities were evaluated of compound 1, crude extract and its fractions so far for the first time. Pharmacological activities results showed that n-butanol fraction was good active against Pseudomonas aeruginosa and Salmonella typhi bacteria, and moderate active against Microsporum canis fungus. Crude extract, n-butanol and aqueous fractions showed good cytotoxicity. Moreover, compound 1, extract and all fractions showed notable phytotoxicity at higher concentrations, whereas all inactive against assayed insects.     

Insights into the binding mechanism of 2,5-substituted 4-pyrone derivatives as therapeutic agents for fused dimeric interactions: A computational study using QTAIM,dynamics and docking simulations of protein–ligand complexes

The study is focused on examining 2,5-Substituted 4-Pyrone based compounds through quantum chemical and topological analysis techniques, evaluating the properties of these compounds, including their geometrical structure, intermolecular interactions and assess their possible applications. Additionally, the molecular stability, charge delocalization and UV-Visible data was investigated and compared with the calculated energy and oscillator strength using the TD-DFT approach. The researchers observed that charge transfer occurred within the molecule, indicated by the HOMO and LUMO energies. It was also found that the compound exhibited planarity and higher chemical reactivity. The calculated Mulliken charges and molecular electrostatic potential were used to interpret the Fukui index data that help predict reactive sites and understand the reactivity patterns of specific atoms in a compound. The study is aimed to understand the role of NCI in the molecule under investigation using electron localization functions and localized orbit locator methods. Molecular docking and ADMET studies were conducting involving a detailed MD simulation of a protein-ligand complex using the OPLS3e force field and the SPC water model. These findings could prove to be beneficial in developing new therapeutic agents with various pharmacological effects and potential toxicities.     

Synthesis of highly fluorescent and water soluble perylene bisimide

Designed and synthesized a new highly water soluble N,N¹-bis（2-（（5-（（dimethylamino）methyl）furan-2-yl）methylthio）ethyl）-perylene -3,4,9,10-tetracarboxylic diimide from 2-（（5-（（dimethylamino）methyl）furan-2-yl）methylthio）ethanamine and perylene-3,4,9,10- tetracarboxylic dianhydride.The compound was characterized by ¹H,¹³C,2D NMR,mass and IR techniques.The compound is highly fluorescent with good solubility in water and other polar solvents.     

A Validated LC Method for the Quantitation of Cefotaxime in pH-Sensitive Nanoparticles

A sensitive and rapid routine LC method was validated for measuring cefotaxime incorporated in three different pH-sensitive nanoparticles. The drug was chromatographed on a C18 reversed-phase column; the mobile phase used was 0.05 M aqueous ammonium acetate, acetonitrile and tetrahydrofuran (87:11:2, v/v) adjusted to pH 5.5 with acetic acid. The flow rate was 1 mL min^?1 and cefotaxime was quantified at 254 nm, with a sensitivity range of 0.005 AUFS. The validated method was specific, linear (R ² ≥ 0.999), precise and accurate in a concentration range of 0.2–50.0 μg mL^?1. The method was rapid, selective and suitable for evaluation of cefotaxime in pH-sensitive Eudragit nanoparticles.     

Fabrication of magnetite nanoparticles (Fe3O4-NPs) for catalytic pyrolysis of nutshells biomass

The fabrication of nanoparticles has been perused as a topic of critical importance in the present decades. Biosynthesis of nanoparticles employs plants extract instead of harmful chemicals. These plant extracts act as reducing and capping agents which is the most appropriate and eco-friendly method among all the preparative routs. In present study, the magnetite nanoparticles (Fe₃O₄-NPs) were fabricated using rapid, single step and benign biosynthetic rout by reduction of ferric nitrate nonahydrate solution with Ferocactus echidne aqueous extract containing ascorbic acid as a main reducing and capping agent. The structural and morphological properties of prepared iron oxide nanoparticles were investigated by Powder X-ray diffraction and scanning electron microscopy. The size of the synthesized nanoparticles was approximately 15 ± 2 nm as determined by Scherrer equation. The biosynthetically fabricated nanoparticles were employed as catalyst for pyrolysis of nutshells to produce biofuel. Catalytic pyrolysis of biomass yields biofuel as an alternative source of energy and chemical feed stock. Effect of temperature, heating rate, and amount of catalyst were investigated on conversion percentage and product yields. Aniline point, carbon residue, and cetane number of prepared bio-oil were also determined.     

Enhancement in Aqueous Solubility of Mefenamic Acid using Micellar Solutions of Various Surfactants

Journal of Solution Chemistry - The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to both the pharmaceutical industry and...