Conformational analysis of 2‐alkyl‐4‐methyl‐2,6‐diphenyl‐2H‐thiopyran derivatives: A combined experimental and theoretical study

Some 2‐alkyl‐4‐methyl‐2,6‐diphenyl‐2H‐thiopyrans were synthesized, and the crystal structure of 2‐tert‐butyl‐4‐methyl‐2,6‐diphenyl‐2H‐thiopyran 1 was determined by single‐crystal X‐ray diffraction. X‐ray crystallographic analysis and ab initio HF/6‐31G(d) and B3LYP/6‐31G(d) calculations revealed a favorable nonplanar half‐chair conformation for these compounds in which two ethylene units were rotated relative to each other around the single bond. The most conspicuous feature was the orientation of alkyl and phenyl groups with respect to the S atom. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:142–147, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20192     

Determination of Salbutamol, Amikacin and Paromomycin Sulfate by a Novel Sulfate Polymeric Membrane Sensor Based on 2,6-diphenyl 4-(4-methoxyphenyl) pyrylium perchlorate

A novel sulfate polymeric membrane sensor based on 2,6-diphenyl 4-(4-methoxyphenyl) pyrylium perchlorate (DMPP) as a sensing material is presented. The electrode displays a very low detection limit (4.0×10^–7M) and wide working concentration range (8.0×10^–7–1.0×10^–1M). The sensor shows remarkable selectivity toward sulfate over most common organic and inorganic anions, including chloride, acetate, nitrate, nitrite, bromide, iodide, thiocyanate, phosphate, fluoride, sulfite, hydrogen sulfite, hydrogen carbonate, citrate, tartarate and oxalate. The sensor reveals a Nernstian behavior (slope of –29.7±0.5mV per decade) in a wide pH range (3.0–9.5). The proposed sensor shows a short response time over the entire working range (15s) and was successfully applied to the direct determination of salbutamol, amikacin and paromomycin sulfate.     

Extension of elliptic curves on Krasner hyperfields

The aim of the article is to initiate a new study in the framework of algebraic hyperfields, with an applicative impact in cryptography. First we define the notions of generalized Weierstrass equation and elliptic hypercurve on Krasner hyperfields, as a generalization of the notion of elliptic curve on fields. Then we investigate properties of the hypergroups derived from elliptic hypercurves and of the associated H_v-groups. Finally, we present a class of canonical hypergroups, which can be used as an alphabet in a special cryptographic system.     

Step-wise and one-step vacuum pyrolysis of birch-derived biomass to monitor the evolution of phenols

One-step and stepwise laboratory batch vacuum pyrolysis of a mixture of birch bark (ca. 46%) and birch sapwood (ca. 54%) was carried out in the temperature range 25–550°C. The pyrolysis oil (defined as the total condensates, including water and organics) was analyzed by GC–MSD and the quantity of phenols (referred to monolignols in this paper) was determined as a function of temperature. The active zone of decomposition and the maximum recovery of phenols were found to be in the temperature range 275–350°C. Distribution of phenols, charcoal and water as a function of temperature was investigated. Stepwise and one-step pyrolysis yielded total phenols of 4.43 and 2.51 wt.% (anhydrous feed basis), respectively. The yields of pyrolysis oil (62.39 wt.%), wood charcoal (23.25 wt.%) and gas ( 14.36 wt.%) produced by both methods were approximately similar, on an anhydrous feed basis.     

Enhancing endothelial differentiation of human mesenchymal stem cells by culture on a nanofibrous polycaprolactone/(poly-glycerol sebacate)/gelatin scaffold

Cardiovascular diseases have always been one of the main causes of death worldwide and eventually one of the major medical concerns. Tissue engineering is promising strategies of treating cardiovascular, which can be an effective approach with the design of appropriate scaffold. In this study, to develop engineering basement membrane for endothelial differentiation with good cell attachment, we produced polycaprolactone (PCL)/poly (glycerol sebacate) (PGS)/gelatin nanofibrous scaffold via electrospinning. Attenuated total reflectance-Fourier transform infrared and the proton nuclear magnetic resonance results confirmed the chemical structure of synthesized PGS. Scanning electron microscope images of the electrospun scaffold revealed that the nanofibers are smooth, continues and uniform. Moreover, due to the presence of hydrophilic functional groups in the scaffold, the contact angle is in the appropriate range for cell adhesion especially endothelial cells. The elastic modulus and ultimate tensile stress of electrospun scaffold were calculated 1.32 ± 0.27 MPa and 1.23 ± 0.18 MPa respectively. Quantitative polymerase chain reaction was performed for evaluation of endothelial differentiation of mesenchymal stem cells cultured on standard plate and fibrous scaffold under chemical stimulation with growth factor. Specific endothelial gene expression results postulated that our modified scaffold could support and significantly promote endothelial differentiation of MSCs.