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排序方式: 共有920条查询结果,搜索用时 46 毫秒
911.
TA Hay YA Ilinskii EA Zabolotskaya MF Hamilton 《The Journal of the Acoustical Society of America》2012,132(1):124-137
A model is presented for a pulsating spherical bubble positioned at a fixed location in a viscous, compressible liquid between parallel viscoelastic layers of finite thickness. The Green's function for particle displacement is found and utilized to derive an expression for the radiation load imposed on the bubble by the layers. Although the radiation load is derived for linear harmonic motion it may be incorporated into an equation for the nonlinear radial dynamics of the bubble. This expression is valid if the strain magnitudes in the viscoelastic layer remain small. Dependence of bubble pulsation on the viscoelastic and geometric parameters of the layers is demonstrated through numerical simulations. 相似文献
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V.P. Markevich A.R. Peaker B. Hamilton S.B. Lastovskii L.I. Murin J. Coutinho A.V. Markevich M.J. Rayson P.R. Briddon B.G. Svensson 《Physica B: Condensed Matter》2012,407(15):2974-2977
Disappearance of the divacancy (V2) and trivacancy (V3) complexes upon isochronal and isothermal annealing of electron irradiated Si:O crystals has been studied by means of deep level transient spectroscopy. The annealing studies have shown that the V2 and V3 defects are mobile in Si at T>200 °C and in oxygen-rich material are trapped by interstitial oxygen atoms so resulting in the appearance of V2O and V3O defects. The activation energies for diffusion of the V2 and V3 centers have been determined. Density functional modeling calculations have been carried out to investigate the migration and reorientation mechanisms of V3 in large silicon supercells. It is proposed that these comprise a sequence of transformations between V3(D3) and V3(C2v) configurations. 相似文献
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BACKGROUND: Human telomerase has an essential RNA component and is an ideal target for developing rules correlating oligonucleotide chemistry with disruption of biological function. Similarly, peptide nucleic acids (PNAs), DNA analogs that bind complementary sequences with high affinity, are outstanding candidates for inducing phenotypic changes through hybridization. RESULTS: We identify PNAs directed to nontemplate regions of the telomerase RNA that can overcome RNA secondary structure and inhibit telomerase by intercepting the RNA component prior to holoenzyme assembly. Relative potencies of inhibition delineate putative structural domains. We describe a novel protocol for introducing PNAs into eukaryotic cells and report efficient inhibition of cellular telomerase by PNAs. CONCLUSIONS: PNAs directed to nontemplate regions are a new class of telomerase inhibitor and may contribute to the development of novel antiproliferative agents. The dependence of inhibition by nontemplate-directed PNAs on target sequence suggests that PNAs have great potential for mapping nucleic acid structure and predictably regulating biological processes. Our simple method for introducing PNAs into cells will not only be useful for probing the complex biology surrounding telomere length maintenance but can be broadly applied for controlling gene expression and functional genomics. 相似文献
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Early detection has led to increased survival for multiple cancers; however, the 5-year survival rate of oral carcinoma (OC) has remained at 40% for the last several decades. Screening for OC is routinely done via visual examinations, followed by tissue biopsy and laboratory testing. Point-of-care testing would be a more convenient and widely available alternative for at-risk individuals. Increased lactate production is a hallmark of many head-and-neck tumors, due to the Warburg Effect, where tumor cells favor glycolysis in the place of oxidative phosphorylation. To detect excess lactate, we have modified the commensal bacterium Escherichia coli Nissle 1917 to express fluorescent reporter genes in response to extracellular lactate. Administering this commensal as a mouth wash and subsequently collecting saliva for the detection of the reporter may allow for noninvasive, early detection of cancerous lesions in at-risk individuals. Furthermore, we demonstrate a new on-chip electrokinetic technique to recover these probiotic probes from model saliva fluid to improve the detection of reporter gene activation. 相似文献
919.
Adrian Adamescu Holly Gray Katherine M. E. Stewart I. P. Hamilton Hind A. Al‐Abadleh 《ChemInform》2010,41(15):no-no
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 相似文献
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