Finite-amplitude disturbances in self-gravitating media. II

This paper deals with finite-amplitude axisymmetric disturbances in a self-gravitating fluid column of finite radius R. It is shown that the cutoff wavelength λ_nl above which gravitational breakup occurs now depends on the relative amplitude $\text{?}\text{R}$ of the initial perturbation. Actually, for small-but finite-amplitude disturbances, $\text{λ}{}_{\mathrm{nl}}\text{=}\text{λ}{}_{\mathrm{l}}\text{(1 ? 0.34368}\text{?}{}^2\text{R}{}^2\text{)}$, where λ_l ( = 5.8898R) designates the cutoff wavelength predicted in the linear approximation.     

Use of Induced Circularly Polarized Luminescence (CPL) from Racemic D3 Lanthanide Complexes to Determine the Absolute Configuration of Amino Acids

The perturbation of the racemic equilibrium of luminescent D₃ lanthanide(III) complexes by added chiral agents, such as amino acids, may be a useful technique for determining the absolute configuration of the added species. It is shown in this work, however, that simple interpretation of the equilibrium shift of racemic tris-terdentate complexes of Tb(III) with 2,6-pyridine-dicarboxylate by amino acids, as measured by the sign of the resultant circularly polarized luminescence (CPL) in terms of specific structural characteristics is not possible. CPL results for a number of derivatized amino acids are also presented, and some insights into the nature of the chiral discriminatory forces that might be exploited in this kind of study are discussed.     

Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile

Inhibition of gamma-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce pathogenic A beta peptides, is an attractive approach for the treatment of Alzheimer's disease. We have designed a new gamma-secretase thiazolamide inhibitor bearing a dihydronicotinoyl moiety as Redox Delivery System which allows specific delivery of the drug to the brain. Through, on the one hand, A beta peptide production measurements by specific in vitro assays (gamma-secretase Cell Free assay and Cell Based assay on HEK 293 APP transfected cells) and, on the other hand, pharmacokinetic studies on animal models, the new inhibitor shows a good pharmacokinetic profile as well as a potent gamma-secretase inhibitory activity in vitro. From the obtained results, it is expected that drug will be mainly delivered to the CNS with low diffusion in the peripheral tissues. Consequently the side effects of this gamma-secretase inhibitor on the immune cells could be reduced.     

Phase-sensitive optical low-coherence reflectometry technique applied to the characterization of photonic crystal fiber properties

Localized measurements of group-velocity dispersion and birefringence of photonic crystal fibers are achieved with a phase-sensitive optical low-coherence reflectometry technique. This technique is efficient for fiber samples no longer than 1 m. Theoretical simulations are in good agreement with experimental results. As a result, the stress-induced birefringence proves to be at most 1 order of magnitude below the geometrical-shape birefringence.     

Second mode transition in microstructured optical fibers: determination of the critical geometrical parameter and study of the matrix refractive index and effects of cladding size

We carried out a numerical study of the second mode transition in finite-sized, microstructured optical fibers (MOFs) for several values of the matrix refractive index. We determined a unique critical geometrical parameter for the second mode cutoff that is valid for all the matrix refractive indices studied. Finite size effects and extrapolated results for infinite structures are described. Using scaling laws, we provide a generalized phase diagram for solid-core MOFs that is valid for all refractive indices, including those of the promising chalcogenide MOFs.     

Comparison of an analytic horn equation approach and a boundary element method for the calculation of sound fields in the human ear canal

The sound field inside a model human ear canal has been computed, to show both longitudinal variations along the canal length and transverse variations through cross-sectional slices. Two methods of computation were used. A modified horn equation approach parametrizes the sound field with a single coordinate, the position along a curved center axis-this approach can accommodate the curvature and varying cross-sectional area of the ear canal but cannot compute transverse variations of the sound field. A boundary element method (BEM) was also implemented to compute the full three-dimensional sound field. Over 2000 triangular mesh elements were used to represent the ear canal geometry. For a plane piston source at the entrance plane, the pressure along the curved center axis predicted by the two methods is in good agreement, for frequencies up to 15 kHz, for four different ear canals. The BEM approach, though, reveals spatial variations of sound pressure within each canal cross section. These variations are small below 4 kHz, but increase with frequency, reaching 1.5 dB at 8 kHz and 4.5 dB at 15 kHz. For source configurations that are more realistic than a simple piston, large transverse variations in sound pressure are anticipated in the vicinity of the source.     

Weak localization in multiterminal networks of diffusive wires

We study the quantum transport through networks of diffusive wires connected to reservoirs in the Landauer-Büttiker formalism. The elements of the conductance matrix are computed by the diagrammatic method. We recover the combination of classical resistances and obtain the weak localization corrections. For arbitrary networks, we show how the Cooperon must be properly weighted over the different wires. Its nonlocality is clearly analyzed. We predict a new geometrical effect that may change the sign of the weak localization correction in multiterminal geometries.     

Huge fluctuations in weight measurements at the bottom of a two-dimensional vertical sheet of grains

Weight measurements at the bottom of a quasi-2D vertical sheet of static cohesionless grains are carried out. The grains are held between two coaxial cylinders. This peculiar setup allows us to set either periodic or fixed lateral boundary conditions. Huge relative fluctuations in weight measurements appear in case of fixed lateral walls. This may be related to some indetermination in the mobilization state of friction forces on lateral walls. This argument would hold for any piling, but would lead to huge fluctuations in 2D systems only, because of averaging effects in 3D.     

Effect of handset proximity on hearing aid feedback

The increased sensitivity of hearing aids to feedback as a telephone handset is brought near has been studied experimentally and numerically. For the measurements, three different hearing aids were modified so that the open-loop transfer function could be measured. They were mounted in the pinna of a mannikin and the change in open-loop transfer function determined as a function of handset proximity. Increases of over 20 dB were observed, most of this change occurring within the first 10 mm of separation between pinna and handset. Numerical calculations performed using a boundary element technique were in good agreement with the measurements.