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81.
Saleem Tahia Dahpy Marwa Ezzat Ghada Abdelrahman Ghada Abdel-Aziz Essam Farghaly Rania 《Applied biochemistry and biotechnology》2019,188(3):854-867
Applied Biochemistry and Biotechnology - Altered plasma levels of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) may predict the development of insulin resistance and other type... 相似文献
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Abstract This review supply an inclusive survey of the recent progress in the chemistry of 4,6‐dimethyl-3-amino-3H-pyrazolo[3,4-b]pyridine concerning the synthesis and reactions and biological activity over the period from the year 1990 to the year 2020. 相似文献
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Asran Aml M. Mohamed Mona A. Khedr Ghada E. Eldin Ghada M. G. Yehia Ali M. Mishra Rupesh K. Allam Nageh K. 《Journal of Thermal Analysis and Calorimetry》2022,147(10):5779-5786
Journal of Thermal Analysis and Calorimetry - The thermal decomposition of the third-generation beta-blocker nebivolol (NEB) was investigated using thermogravimetric analysis (TG) under isothermal... 相似文献
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Shwetha U R Rajith Kumar C R Kiran M S Virupaxappa S. Betageri Latha M S Ravindra Veerapur Ghada Lamraoui Abdulaziz A. Al-Kheraif Abdallah M. Elgorban Asad Syed Chandan Shivamallu Shiva Prasad Kollur 《Molecules (Basel, Switzerland)》2021,26(9)
Nanoworld is an attractive sphere with the potential to explore novel nanomaterials with valuable applications in medicinal science. Herein, we report an efficient and ecofriendly approach for the synthesis of Nickel oxide nanoparticles (NiO NPs) via a solution combustion method using Areca catechu leaf extract. As-prepared NiO NPs were characterized using various analytical tools such as powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV-Visible spectroscopy (UV-Vis). XRD analysis illustrates that synthesized NiO NPs are hexagonal structured crystallites with an average size of 5.46 nm and a hexagonal-shaped morphology with slight agglomeration. The morphology, size, and shape of the obtained material was further confirmed using SEM and TEM analysis. In addition, as-prepared NiO NPs have shown potential antidiabetic and anticancer properties. Our results suggest that the inhibition of α-amylase enzyme with IC 50 value 268.13 µg/mL may be one of the feasible ways through which the NiO NPs exert their hypoglycemic effect. Furthermore, cytotoxic activity performed using NiO NPs exhibited against human lung cancer cell line (A549) proved that the prepared NiO NPs have significant anticancer activity with 93.349 μg/mL at 50% inhibition concentration. The biological assay results revealed that NiO NPs exhibited significant cytotoxicity against human lung cancer cell line (A549) in a dose-dependent manner from 0–100 μg/mL, showing considerable cell viability. Further, the systematic approach deliberates the NiO NPs as a function of phenolic extracts of A. catechu with vast potential for many biological and biomedical applications. 相似文献
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Nasser Mohammed Hosny Ghada Samir Mohamed Shafick Zoromba Samir Alghool 《Polymer Science Series B》2017,59(1):91-96
Poly(m-phenylene diamine) has been synthesized and characterized by physical and spectral techniques. The effect of doping Cr, Co and Ni ions on the spectral, thermal and optical properties has been studied. Optical band gap measurements indicated that, doped polymers have wider optical band gap than the pure one. The effect of doping on the thermal stability differs according to the doped metal ion. The doped with Cr ions poly(m-phenylenediamine) has been used as a precursor of mesoporous Cr2O3 nanoparticles, which have been also characterized by XRD and HR-TEM. 相似文献
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Ghada H. Yassin Christian Grun Jean H. Koek Khaleel I. Assaf Nikolai Kuhnert 《Journal of mass spectrometry : JMS》2014,49(11):1086-1095
Ultra performance liquid chromatography (UPLC) when coupled to ion mobility (IMS)/orthogonal acceleration time of flight mass spectrometry is a suitable technique for analyzing complex mixtures such as the black tea thearubigins. With the aid of this advanced instrumental analysis, we were able to separate and identify different isomeric components in the complex mixture which could previously not be differentiated by a conventional high performance liquid chromatography/tandem mass spectrometry. In this study, the difference between isomeric structures theasinensins, proanthocyanidins B‐type and rutin (quercetin‐3O‐rutinoside) were studied, and these are present abundantly in many botanical sources. The differentiation between these structures was accomplished according to their acquired mobility drift times differing from the traditional investigations in mass spectrometry, where calculation of theoretical collisional cross sections allowed assignment of the individual isomeric structures. The present work demonstrates UPLC–IMS‐MS as an efficient technology for isolating and separating isobaric and isomeric structures existing in complex mixtures discriminating between them according to their characteristic fragment ions and mobility drift times. Therefore, a rational assignment of isomeric structures in many phenolic secondary metabolites based on the ion mobility data might be useful in mass spectrometry‐based structure analysis in the future. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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Multivariate spectrophotometric calibration and liquid chromatographic (LC) methods were applied to the determination of 2 multicomponent mixtures containing diprophylline, guaiphenesin, methylparaben, and propylparaben (Mixture 1), or clobutinol, orciprenaline, saccharin sodium, and sodium benzoate (Mixture 2). For the multivariate spectrophotometric calibration methods, principal component regression (PCR) and partial least-squares regression (PLS-1), a calibration set of the mixtures consisting of the components of each mixture was prepared in 0.1 M HCl. Analytical figures of merit such as sensitivity, selectivity, limit of quantitation, and limit of detection were determined for both PLS-1 and PCR. The LC separation was achieved on a reversed-phase C18 analytical column by using isocratic elution with 20 mM potassium dihydrogen phosphate, pH 3.3-acetonitrile (55 + 45, v/v) as the mobile phase and UV detection at 260 and 220 nm for Mixture 1 and Mixture 2, respectively. The proposed methods were validated and successfully applied to the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing the 2 multicomponent combinations. 相似文献