The chemistry of O-silylated ketene acetals; diastereoselective Aldol reaction of 2,3-O-isopropylidene-D (and L)-glyceraldehydes leading to 2-deoxy-D (and L)-riboses

Diastereoselective carbon-carbon bond forming reaction of 2,3-O-isopropylidene-D (and L)-glyceraldehydes (D and L-2) with ketene silyl acetals (1a,b) occurred in acetonitrile under mild conditions to give the corresponding $\text{anti}$-β-siloxyesters (D and L-3a) as major products, which could be converted through a few additional steps to 2-deoxy-D(and L)-riboses.     

Synthesis and reaction of a new type of 5-deazaflavin with axial and planar chirality

A new type of 5-deazaflavin derivative with axial and planar chirality was synthesized as a flavoenzyme model. A novel optical resolution gave an enantiomeric pair of the 5-deazaflavins 1a,b. Compounds1a,b were optically stable and effectively discriminated PNPH enantiomers in a model reaction of intercoenzyme hydrogen transfer.     

Base promoted oxidative decarboxylation of ethyl phenylglycinate via oxaziridine

Base catalyzed decompositions of 2-(α-ethoxycarbonyl-benzyl)-3-phenyl-oxaziridines carried out in benzene in an atmosphere of oxygen yielded N-benzoyl benzamides along with ethyl phenylglyoxylate imine and benzaldehydes.     

Studies on vocal fold injection and changes in pitch associated with alcohol intake

The current study was carried out with particular emphasis on the association between phonetic function tests and alterations in the appearance of the hypopharyngeal and laryngeal mucosa, such as capillary dilatation, edema, and vocal fold injection after alcohol intake. The results demonstrated the occurrence of previously unrecognized pathophysiological changes associated with synchronous phonetic functions in the vocal pathway after alcohol intake. Serum ethanol and aldehyde concentration levels were evaluated hourly for 2.5 h after ingestion of alcohol. When an electronystagmogram showed the typical pattern of alcohol intake, the study was initiated. Occasionally, rhinography was performed on subjects complaining of a stuffy nose after alcohol intake.     

Preparation of chiral 5-deazaflavin derivatives and their asymmetric reduction of ethyl benzoylformate

1,5-Dihydro-5-deazaflavin derivatives possessing a chiral substituent at N(3) position were synthesized, with which moderate asymmetric induction was observed in the reduction of ethyl benzoylformate.     

Comparison of the equilibrium geometry of acetylene (C2H2) and disilyne (Si2H2)

The equilibrium geometry of disilyne is not linear, but is twisted. The potential surfaces of acetylene and disilyne have a critical internuclear distance between the central atoms, where the stable geometry changes from linear to twisted forms the R-dependence of the valence-shell electron energy causes the difference in the structure of the molecules.