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61.
Dr. Sudhir Kumar Keshri Dr. Waka Nakanishi Dr. Atsuro Takai Prof. Dr. Tomoya Ishizuka Prof. Dr. Takahiko Kojima Prof. Dr. Masayuki Takeuchi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(58):13288-13294
The design and synthesis of a tweezer-shaped naphthalenediimide (NDI)–anthracene conjugate ( 2NDI ) are reported. In the structure of the closed form (πNDI ⋅⋅⋅ πNDI stack) of 2NDI , which was elucidated by single-crystal XRD, the existence of C−H ⋅⋅⋅ O hydrogen bonding involving the nearest carbonyl oxygen atom of an NDI unit was suggested. The tunability of πNDI ⋅⋅⋅ πNDI interactions was studied by means of UV/Vis absorption, fluorescence and NMR spectroscopy and molecular modelling. This revealed that the πNDI ⋅⋅⋅ πNDI interactions in 2NDI affect the absorption and emission properties depending on the temperature. Furthermore, in polar solvents, 2NDI prefers the stronger πNDI ⋅⋅⋅ πNDI stack, whereas the πNDI ⋅⋅⋅ πNDI interaction is diminished in nonpolar solvents. Importantly, the conformational variations of 2NDI can be reversibly switched by variation in temperature, and this suggests potential application for fluorogenic molecular switches upon temperature changes. 相似文献
62.
Masataka Hakamada Motohiro Yuasa Takashi Yoshida Fumi Hirashima Mamoru Mabuchi 《Applied Physics A: Materials Science & Processing》2014,114(4):1061-1066
ZnO deposited on nanoporous Au showed photocatalytic decomposition toward methyl orange under visible light, unlike ZnO sputtered on flat Au without a nanoporous structure. First-principles calculations suggested that the surface lattice disorder in nanoporous Au induced a band gap narrowing and a large built-in electric field in the adjacent ZnO, resulting in the visible-light photocatalytic response. 相似文献
63.
Barbara Fumić Marijana Zovko Končić Mario Jug 《Journal of inclusion phenomena and macrocyclic chemistry》2018,92(3-4):369-379
A novel sustainable and eco-friendly procedure simultaneously combining the use of ultrasound irradiation and hydroxypropyl-β-cyclodextrin (HPβCD) complexation was used to extract phytochemicals from Lotus corniculatus and to prepare flavonoid rich extract having potential as substrate reduction therapy of mucopolysaccharidosis type III (MPS III), a rare autosomal recessive lysosomal storage disorder. For that instance, Box-Behnken design and response surface methodology was employed to statistically assess the influence of HPβCD concentration, ultrasonic power, and extraction time on the total phenolic compounds, total flavonoids, total phenolic acids and radical scavenging activity (RSA) of the extracts prepared, chosen as the responses indicative of the product quality and performance. The potential of such optimised extract to modulate accumulation of gylcosoaminoglycans (GAGs) was evaluated on the fibroblast obtained from patients suffering from MPS type III. Optimized extract prepared by 45 min extraction using HPβCD at concentration of 20 mM and ultrasonic irradiation of 648 W was rich in flavonoids (1.36 mg/mL) and showed notable RSA of 1.04 mg/mL. Freeze-dried extract, at concentration of 3 and 6 µg/mL, reduced GAG levels in skin fibroblasts by 33.97 and 50.08%, respectively, without any toxic effects at given doses, showing a potential to be considered as a part of the substrate reduction therapy of MPS III. 相似文献
64.
Iridium‐Catalyzed Sequential Silylation and Borylation of Heteroarenes Based on Regioselective C−H Bond Activation
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Dr. Masahito Murai Naoki Nishinaka Prof. Dr. Kazuhiko Takai 《Angewandte Chemie (International ed. in English)》2018,57(20):5843-5847
An iridium‐catalyzed regioselective sequential silylation and borylation of heteroarenes was developed, which represents a rare example of unsymmetrical intermolecular C?H bond difunctionalization through the introduction of two different functionalities during a one‐pot transformation. Although the substrate scope for the dehydrogenative silylation of heteroarenes has been limited mainly to electron‐rich five‐membered rings, the current reaction proceeds with both electron‐rich and electron‐deficient heteroarenes with the aid of heteroatom‐directing C?H bond activation. The regioselectivity of the second borylation was controlled by both steric factors and the electronic effect of the silyl group installed in the first step. In combination with the classic cross‐coupling reaction, this method provides rapid access to multisubstituted heteroarenes. 相似文献
65.
Nanographene has a unique electronic structure which critically depends on the shape of its edge. A zigzag-edged nanographene sheet has a non-bonding pi-electron state (edge state), yielding a strong spin magnetism for edge-state localized spins, in spite of the absence of such a state in an armchair-edged nanographene sheet. Nanographite (stacked nanographene sheets)-network-based nanoporous carbon is employed as the host material to build unconventional magnetic systems based on the host-guest interaction. The physisorption of various guest materials can cause a reversible low-spin/high-spin magnetic switching phenomenon, whose feature varies depending on the type of guest species. The edge-state spins are utilized as a probe to detect a huge condensation of helium atoms in the nanopores. The giant magnetoresistance of the nanographite network is controlled by the physisorption of magnetic oxygen molecules. The confinement of potassium clusters in the nanopores surrounded by nanographite domains yields an interesting nanomagnetic state. Nanographene/nanographite is an intriguing pi-electron-based nanocarbon material with the potential of producing unconventional magnetic structures that cannot be obtained using bulk graphite. The processability of nanographene/nanographite is expected to give a variety of magnetic functions for spintronic applications. 相似文献
66.
Rapid development of hydrophilicity and protein adsorption resistance by polymer surfaces bearing phosphorylcholine and naphthalene groups 总被引:1,自引:0,他引:1
Futamura K Matsuno R Konno T Takai M Ishihara K 《Langmuir : the ACS journal of surfaces and colloids》2008,24(18):10340-10344
In order to provide a protein adsorption resistant surface even when the surface was in contact with a protein solution under completely dry conditions, a new phospholipid copolymer, poly (2-methacryloyloxyethyl phosphorylcholine (MPC)- co-2-vinylnaphthalene (vN)) (PMvN), was synthesized. Poly(ethylene terephthalate) (PET) could be readily coated with PMvN by a solvent evaporation method. Dynamic contact angle measurements with water revealed that the surface was wetted very rapidly and had strong hydrophilic characteristics; moreover, molecular mobility at the surface was extremely low. When the surface came in contact with a plasma protein solution containing bovine serum albumin (BSA), the amounts of the plasma protein adsorbed on the dry surface coated with PMvN and that adsorbed on a dry surface coated with poly(MPC-co-n-butyl methacrylate) (PMB) were compared. Substantially lower protein adsorption was observed with PMvN coating. This is due to the rapid hydration behavior of PMvN. We concluded that PMvN can be used as a functional coating material for medical devices without any wetting pretreatment. 相似文献
67.
68.
A type of charged phospholipid polymer biointerface was constructed on a quartz microfluidic chip to control the electroosmotic flow (EOF) and to suppress non-specific protein adsorption through one-step modification. A negatively charged phospholipid copolymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), potassium 3-methacryloyloxypropyl sulfonate (PMPS) and 3-methacryloxypropyl trimethoxysilane (MPTMSi) moieties (referred to as PMBSSi) was synthesized to introduce such phosphorylcholine segments as well as surface charges onto the silica-based microchannels via chemical bonding. At neutral pH, the homogenous microchannel surface modified with 0.3 wt% PMBSSi in alcoholic solution, retained a significant cathodic EOF ((1.0 +/- 0.1) x 10(-4) cm(2) V(-1) s(-1)) with approximately one-half of the EOF of the unmodified microchannel ((1.9 +/- 0.1) x 10(-4) cm(2) V(-1) s(-1)). Along with another non-charged copolymer (poly(MPC-co-MPTMSi), PMSi), the regulation of the surface charge density can be realized by adjusting the concentration of PMBSSi or PMSi initial solutions for modification. Coincidently, the zeta-potential and the EOF mobility at neutral pH showed a monotonically descending trend with the decrease in the charge densities on the surfaces. This provides a simple but feasible approach to controlling the EOF, especially with regard to satisfying the requisites of miniaturized systems for biological applications requiring neutral buffer conditions. In addition, the EOF in microchannels modified with PMBSSi and PMSi could maintain stability for a long time at neutral pH. In contrast to the EOF in the unmodified microchannel, the EOF in the modified microchannel was only slightly affected by the change in pH (from 1 to 10). Most importantly, although PMBSSi possesses negative charges, the non-specific adsorptions of both anionic and cationic proteins (considering albumin and cytochrome c, respectively, as examples) were effectively suppressed to a level of 0.15 microg cm(-2) and lesser in the case of the 0.3 wt% PMBSSi modification. Consequently, the variation in the EOF mobility resulting from the protein adsorption was also suppressed simultaneously. To facilitate easy EOF control with compatibility to biomolecules delivered in the microfluidic devices, the charged interface described could provide a promising option. 相似文献
69.
Novel stearolic acid analogs (i.e., 9-octadecynoic acid analogs: 1a-d) containing the shorter perfluoroalkyl groups, CF3, C2F5, n-C3F7 or n-C4F9 group were synthesized. Equilibrium spreading pressures (πes) of their monolayers at the air-water interface were measured in order to demonstrate how the fluorine content has an effect on the stability of the fatty acid monolayers. As the fluorine content in stearolic acid molecule increased, its melting points was lowered indicating the solid bulk phase of stearolic acid became thermally unstable, while its monolayer stability evaluated by πe at 25 °C, dramatically increased and subsequently leveled off above a certain fluorine content. Under this condition, the replacement of at least five hydrogen atoms at the terminal hydrophobic segment in stearolic acid molecule by fluorine atoms (CF3CF2 group) was required to alter the bulk property of stearolic acid and exhibit the stabilization of monolayers, whereas further fluorination of stearolic acid had a minor effect on the monolayer stability. This behavior suggests the terminal fluorinated hydrophobic segment exclusively controls the interfacial stability of fatty acid monolayers. 相似文献
70.
Surface modification of polymer materials for preparing microfluidic devices including poly(dimethyl siloxane) (PDMS) was investigated with phospholipids polymers such as poly(2-methacryloyloxylethyl phosphorylcholine(MPC)-co-n-butyl methacrylate) (PMB) and poly(MPC-co-2-ethylhexyl methacrylate-co-2-(N,N-dimethylamino)ethyl methacrylate) (PMED). The hydrophilicity of every surface on the polymer materials modified with these MPC polymers increased and the value of zeta-potential became close to zero. The protein adsorption on the polymer materials with and without the surface modification was evaluated using a protein mixture of human plasma fibrinogen and serum albumin. Amount of proteins adsorbed on these polymeric materials showed significant reduction by the surface modification with the MPC polymers compared to the uncoated surfaces ranging from 56 to 90%. Furthermore, we successfully prepared PDMS-based microchannel which was modified by simple coating with the PMB and PMED. The modified microchannel also revealed a significant reduction of adsorption of serum albumin. We conclude that the MPC polymers are useful for reducing unfavorable protein adsorption on microfluidic devices. 相似文献