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21.
Baptiste Picard Boris Gouilleux Dr. Thomas Lebleu Dr. Jacques Maddaluno Prof. Isabelle Chataigner Dr. Maël Penhoat Prof. François-Xavier Felpin Dr. Patrick Giraudeau Dr. Julien Legros 《Angewandte Chemie (International ed. in English)》2017,56(26):7568-7572
The fast and effective neutralization of the mustard-gas simulant 2-chloroethyl ethyl sulfide (CEES) using a simple and portable continuous flow device is reported. Neutralization takes place through a fully selective sulfoxidation by a stable source of hydrogen peroxide (alcoholic solution of urea–H2O2 adduct/MeSO3H freshly prepared). The reaction progress can be monitored with an in-line benchtop NMR spectrometer, allowing a real-time adjustment of reaction conditions. Inherent features of millireactors, that is, perfect control of mixing, heat and reaction time, allowed the neutralization of 25 g of pure CEES within 46 minutes in a 21.5 mL millireactor (tR=3.9 minutes). This device, which relies on affordable and nontoxic reagents, fits into a suitcase, and can be deployed by police/military forces directly on the attack site. 相似文献
22.
Harnessing the Dual Properties of Thiol‐Grafted Cellulose Paper for Click Reactions: A Powerful Reducing Agent and Adsorbent for Cu 下载免费PDF全文
Dr. Jordi Rull‐Barrull Martin d'Halluin Dr. Erwan Le Grognec Prof. Dr. François‐Xavier Felpin 《Angewandte Chemie (International ed. in English)》2016,55(43):13549-13552
A new approach exploiting the dual properties of thiol‐grafted cellulose paper for promoting copper‐catalyzed [3+2]‐cycloadditions of organic azides with alkynes and adsorbing residual copper species in solution was developed. The thiol‐grafted cellulose paper, used as a paper strip, effects the reduction of CuII to catalytically active CuI and acts as a powerful adsorbent for copper, thereby facilitating the work‐up process and leaving the crude mixture almost free of copper residues after a single filtration. 相似文献
23.
François‐Xavier Felpin Dr. Jérôme Coste Cécile Zakri Prof. Eric Fouquet Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(29):7238-7245
One‐pot sequential Heck reduction–cyclization (HRC) reactions leading to the synthesis of substituted 2‐quinolones have been developed by using a heterogeneous or mixed homogeneous/heterogeneous multitask palladium catalyst with charcoal as a support. The whole sequence occurs under very mild conditions without the need for additives (ligand or base) by taking advantage of the high reactivity of aryldiazonium salts as “super electrophiles”. Recycling experiments showed that the reused heterogeneous Pd0/C catalyst was not able to promote another HRC sequence but was, however, still highly active for hydrogenation, hydrodehalogenation, as well as hydrogenolysis reactions. 相似文献
24.
Full details of a stereocontrolled and convergent synthetic route to 9a-desmethoxymitomycin A (1) are reported. The target molecule possesses the parent tetrahydropyrrolo[1,2-a]indole ring system characteristic of the mitomycin family of antitumor agents. The synthesis was based on the diastereocontrolled addition of a fully elaborated cinnamylstannane to a pyrrolidine-based N-acyliminium ion as the key convergent step, which resulted in the installation of the C9 and C9a stereogenic centers. 相似文献
25.
Roxan Joncour Dr. Nicolas Susperregui Noël Pinaud Dr. Karinne Miqueu Prof. Eric Fouquet Dr. Jean‐Marc Sotiropoulos Prof. François‐Xavier Felpin 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(28):9291-9296
We describe the coupling of anilines with aryl boronic acids, under ligand‐, base‐, and salt‐free conditions at room temperature. This new reaction proceeds through the formation of an aryl palladium alkoxo complex, which allows the transmetalation step with aryl boronic acids without any external base. Importantly, this sustainable procedure generates only environmentally friendly byproducts such as tBuOH, H2O, N2, and B(OH)3. The reaction mechanism has been deeply investigated through experimental and theoretical studies. 相似文献
26.
Kouakou Eric Konan Prof. Abollé Abollé Prof. François-Xavier Felpin 《European journal of organic chemistry》2023,26(1):e202201055
In this work, we describe ultra-fast continuous flow photo-thiol-ene reactions on cinchona alkaloids derivatives through a control of the reactive conformation in solution. Flow thiol-ene reactions proceed at 32 °C under light irradiation at 365 nm and require only 2.5 minutes of residence time to reach completion. The short path length of the tubular flow photochemical reactor, which maximizes and homogenizes the photon flux, associated to the fine tuning of the reactive conformation of cinchona alkaloids in solution are the main reasons for the high rates observed. The predominant conformation in solution of cinchona alkaloids was adjusted through the substitution of the hydroxyl group at C9 by a phenyl carbamate function. 相似文献