Latoxanthin, a minor carotenoid isolated from the fruits of yellow paprika (Capsicum annuum var. lycopersiciforme flavum)

Latoxanthin was isolated as a minor carotenoid from the ripe fruits of yellow tomato shaped paprika (Capsicum annuum var. lycopersiciforme flavum) and identified as (all-E,3S,5R,6R,3′S,5′R,6′S)-5′,6′-epoxy-5,6,5′,6′-tetrahydro-β,β-carotene-3,5,6,3′-tetrol based on spectral data.     

Thermal,spectral and biological properties of Zn(II) complex compounds with phenazone

The thermal decomposition of the complexes Zn(form)₂⋅2phen (I), Zn(ac)₂⋅2phen (II), Zn(prop)₂⋅2phen (III), Zn(but)₂⋅2phen (IV), where phen=phenazone, form=formiate, ac=acetate, prop=propionate, but=butyrate has been studied in air by TG/DTG and DTA methods. The possible mechanism of the thermal decomposition was proposed. The final product of thermal decomposition was ZnO. IR data show unidentate coordination of carboxylate group to Zn(II) ion. The complexes were tested against various strains of microorganisms and their efficiency decrease in the sequence yeasts >bacteria>filamentous fungi.     

Theory of Multiple NMR Spin Echoes of HD Impurities in Solid Para-H2

The theory of the formation of NMR multiple echoes for isotopic impurities (HD) in solid para-H₂has been developed for the case of weak quantum tunneling of the impurities. The results show that even for low tunneling rates (100–1000 Hz), NMR multiple echoes can be observed for experimentally accessible nuclear spin polarizations and can be used to provide an independent test for the existence of tunneling in the solid hydrogens.     

Models for thermal dissociation of silane on a polysilicon surface

Simple models for the thermally activated dissociation reaction of silane and silicon growth on a polycrystalline silicon surface are presented. The models are fitted to recent experimental molecular beam scattering data for the low-pressure reactive sticking coefficient. Thermally activated few-step models fit the data reasonably well, and thus, we are able to explain the temperature and pressure dependencies of the observed deposition rate.     

Ueber die Metachromasie des Toluidinblaus

Ohne Zusammenfassung     

A Hot‐Segment‐Based Approach for the Design of Cross‐Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self‐Assembly

The design of inhibitors of protein–protein interactions mediating amyloid self‐assembly is a major challenge mainly due to the dynamic nature of the involved structures and interfaces. Interactions of amyloidogenic polypeptides with other proteins are important modulators of self‐assembly. Here we present a hot‐segment‐linking approach to design a series of mimics of the IAPP cross‐amyloid interaction surface with Aβ (ISMs) as nanomolar inhibitors of amyloidogenesis and cytotoxicity of Aβ, IAPP, or both polypeptides. The nature of the linker determines ISM structure and inhibitory function including both potency and target selectivity. Importantly, ISMs effectively suppress both self‐ and cross‐seeded IAPP self‐assembly. Our results provide a novel class of highly potent peptide leads for targeting protein aggregation in Alzheimer’s disease, type 2 diabetes, or both diseases and a chemical approach to inhibit amyloid self‐assembly and pathogenic interactions of other proteins as well.     

The Phosphinoboration Reaction

The synthesis of phosphinoboronate esters containing a single P? B bond is reported, together with preliminary reactivity studies towards a range of organic substrates. These compounds add readily to aldehydes, ketones, aldimines, and α,β‐unsaturated enones to give primarily the corresponding 1,2‐addition products containing a new P? C bond. The first examples of transition‐metal‐catalyzed phosphinoborations of C‐C multiple bonds in which P? C and B? C bonds are formed in a single step are also disclosed; allenes react by a highly regioselective 1,2‐addition whereas terminal alkynes undergo a formal 1,1‐addition.     

Green chemical syntheses and applications within organophosphorus chemistry

Application of the microwave (MW) technique offers many advantages in organophosphorus syntheses. Reluctant reactions may take place on MW irradiation. In most cases, MWs make the reactions more efficient in respect of rate, selectivity and yield. The benefits are shown via representative examples. MW irradiation may replace a catalyst, or simplify catalytic systems. The synthesis of catalysts incorporating heterocyclic P-ligands is also discussed. Where it was relevant, structural chemical details were also provided.