Determination of N-acetylcysteine in human plasma by gas chromatography-mass spectrometry

An automatic mass spectrometric method for the quantitation of N-acetylcysteine (NAC) in human plasma has been developed. NAC was extracted from plasma with ethyl acetate and derivatized in two steps with 2-propanol and pentafluoropropionic anhydride. The volatile derivative obtained was ideal for gas chromatographic-mass spectrometric analysis. Data obtained by analysing the plasma of healthy volunteers to whom 600 mg of NAC had been orally given are reported.     

“4,7-lactams”, intermediates for penems synthesis. I. skeletal conversion of penicillanic acid to (+)-2,2,5,5-tetramethyl-9-oxo-3-oxa-6-thia-azabicyclo[5,2,01,7]nonane

The synthesis of chiral “4,7-lactam“ $\text{5}$ has been accomplished starting from natural 6-aminopenicillanic acid.     

A search for neutrino oscillations

We present here the final results of experiments searching for neutrino oscillations, carried out by the CHARM Collaboration. The data — taking took place in 1983. The first experiment was performed by exposing two detectors simultaneously to the CERN PS low energyv _µ beam. In the second experiment the full CHARM detector was exposed to the wide-band horn-focusedv _µ beam of the CERN SPS. Complete details of the experiments and data reduction are presented. No statistically significant signals for neutrino oscillations were observed. Our 90% CL limits in the appearance experiment (v _µ→v _e ) exclude Δm ²≧0.19 eV² for complete mixing (sin²2θ=1), and sin²2θ≧0.008 for the region Δm ²≧30 eV². These results, and the limits observed for (v _µ→v _x ) (disappearance of (v _µ), are in agreement with those of most other experiments but exclude part of the region previously reported as a possible indication ofv _µ→v _e oscillations.     

Site Location via Mixed-integer Programming

It is demonstrated that mixed-integer programming can be applied successfully to the solution of certain practical site location problems. A mixed-integer model of a frequently occurring form of warehouse location problem is presented. Experience with models of this type is described with examples of computational performance. The flexibility of mixed-integer models and the approach to their use as aids to decision-making are discussed.     

On perturbed derivations of C1 algebras

Given a C¹ algebra $\text{U}$, the generator of a group of automorphisms δ, and a derivation D, we examine some situations in which δ+λD is a generator for small real λ.     

Measurement of the polarization of positive muons produced in high-energy antineutrino interactions

The question whether scalar-type interactions contribute to weak interactions at large momentum transfer has been investigated by a measurement of the longitudinal polarization of positive muons produced in charged-current interactions of high-energy antineutrinos with iron. At an average momentum transfer <Q ²>=4 GeV² the muon spin is found to be oriented forward with respect to the muon momentum vector, with an average polarization of 1.10±0.24, consistent with positive helicity. A limit on scalar contributions of σ_{s, p}/σ_tot <7% at the 95% confidence level can be deduced. A search for violation of time reversal invariance which could manifest itself by a polarization component perpendicular to the muon production plane gave a limit of σ_tv/σ_tot <16% (95% c.l.). It is concluded that the weak leptonic charged current retains its dominant vector and axial vector structure at large momentum transfers.     

A density-functional study of the structures, binding energies and total spins of Ni-Fe clusters using nonlocal norm-conserving pseudopotentials and the generalized gradient approximation

We report ab initio calculations of the structures, binding energies, and total spins of the clusters Ni(13), Ni(19), Ni(23), Ni(26), Ni(12)Fe, Ni(11)Fe(2), Ni(18)Fe, Ni(17)Fe(2), Ni(22)Fe, Ni(20)Fe(3), and Ni(25)Fe using a density-functional method that employs linear combination of atomic orbitals as basis sets, nonlocal norm-conserving pseudopotentials, and the generalized gradient approximation for exchange and correlation. Our results show that the Fe-doped Ni clusters, which have icosahedral or polyicosahedral ground-state structures similar to those of the corresponding pure Ni clusters, are most stable with the Fe atoms occupying internal positions, as has also been inferred from experimental results on the adsorption of molecular nitrogen on the cluster surfaces. We also rule out the possibility that the experimentally observed difference between the (nonpolyicosahedral) configurations of N(2)-saturated Ni(26) and N(2)-saturated Ni(25)Fe be due to the influence of the Fe atom on the energy of the underlying metal cluster.