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61.
Bittrich E Burkert S Müller M Eichhorn KJ Stamm M Uhlmann P 《Langmuir : the ACS journal of surfaces and colloids》2012,28(7):3439-3448
Temperature-sensitive poly(N-isopropylacrylamide) (PNIPAAm) brushes with different molecular weights M(n) and grafting densities σ were prepared by the "grafting-to" method. Changes in their physicochemical properties according to temperature were investigated with the help of in situ spectroscopic ellipsometry and in situ attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy. Brush criteria indicate a transition between a brush conformation below the lower critical solution temperature (LCST) and an intermediate to mushroom conformation above the LCST. By in situ ellipsometry distinct changes in the brush layer parameters (wet thickness, refractive index, buffer content) were observed. A broadening of the temperature region with maximum deswelling occurred with decreasing grafting density. The brush layer properties were independent of the grafting density below the LCST, but showed a virtually monotonic behavior above the LCST. The midtemperature ?(half) of the deswelling process increased with increasing grafting density. Thus grafting density-dependent design parameters for such functional films were presented. For the first time, ATR-FTIR spectroscopy was used to monitor segment density and hydrogen bonding changes of these very thin PNIPAAm brushes as a function of temperature based on significant variations of the methyl stretching, Amide I, as well as Amide II bands with respect to intensity and wavenumber position. No dependence on M(n) and σ in the wavenumber shift of these bands above the LCST was found. The temperature profile of these band intensities and thus segment density was found to be rather step-like, exceeding temperatures around the LCST, while the respective profile of their wavenumber positions suggested continuous structural and hydration processes. Remaining buffer amounts and residual intermolecular segment/water interaction in the collapsed brushes above the LCST could be confirmed by both in situ methods. 相似文献
62.
Eichhorn P Pérez S Aceña J Gardinali P Abad JL Barceló D 《Journal of mass spectrometry : JMS》2012,47(6):701-711
Recent publications on pharmaceutical monitoring are increasingly covering the field of illicit drugs and lately the forensic evaluation of designing illegal analogs of lifestyle drugs like the phosphodiesterase type 5 (PDE-5) inhibitors Viagra (sildenafil), Levitra (vardenafil) and Cialis (tadalafil). Recently, the presence of all three erectile dysfunction treatment drugs has been reported in wastewaters at very low concentrations. In the environment, contaminants undergo various physical or chemical processes classified into abiotic (photolysis, hydrolysis) and biotic (biodegradation) reactions. Thus, changes in the chemical structure lead to the formation of new transformation products, which may persist in the environment or be further degraded. This study describes the photolysis of sildenafil (SDF) and its human metabolite N-demethylsildenafil (DM-SDF) under simulated solar radiation (Xenon lamp). Following chromatographic separation of the irradiated samples, eight photoproducts in the SDF samples and six photoproducts for DM-SDF were detected and characterized. The combination of ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (UPLC-ESI-QToF-MS), liquid chromatography-atmospheric pressure chemical ionization-triple quadrupole mass spectrometry (LC-APCI-QqQ-MS) and hydrogen/deuterium-exchange experiments allowed to propose plausible chemical structures for the photoproducts, taking into account the characteristic fragmentation patterns and the accurate mass measurements. These mass spectral data provided sound evidence for the susceptibility of the piperazine ring toward photodegradation. A gradual breakdown of this heterocyclic structure gave rise to a series of products, which in part were identical for SDF and DM-SDF. The sulfonic acid, as the formal product of sulfonamide hydrolysis, was identified as key intermediate in the photolysis pathway. In both drug/metabolite molecules, phototransformation processes taking place beyond the sulfonamide group were deemed to be of minor relevance. 相似文献
63.
We consider a collapsing spherically symmetric inhomogeneous dust cloud in higher dimensional space-time. We show that the
central singularity of collapse can be a strong curvature or a weak curvature naked singularity depending on the initial density
distribution. 相似文献
64.
Dr. Ai-Min Li Dr. Yi Wang Dr. Domonique O. Downing Dr. Fu Chen Dr. Peter Zavalij Prof. Dr. Alvaro Muñoz-Castro Prof. Dr. Bryan W. Eichhorn 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(26):5824-5833
The icosahedral [M@Pb12]3− (M=Co( 1 ), Rh( 2 ), Ir( 3 )) cluster ions were prepared from K4Pb9 and Co(dppe)Cl2 (dppe=1,2-bis(diphenylphosphino)ethane)/[Rh(PPh3)3Cl]/[Ir(cod)Cl]2 (cod=1,5-cyclooctadiene), respectively, in the presence of 18-crown-6/ 2,2,2-cryptand in ethylenediamine/toluene solvent mixtures. The [K(2,2,2-cryptand)]+ salt of 1 and the [K(18-crown-6)]+ salt of 3 were characterized via X-ray crystallography; the ions 1 and 3 are isostructural and isoelectronic to the [Rh@Pb12]3− ( 2 ) ion as well as to the group 10 clusters [M′@Pb12]2− (M′=Ni, Pd, Pt). The ions are all 26-electron clusters with near perfect icosahedral Ih point symmetry. Clusters 1 – 3 show record downfield 207Pb NMR chemical shifts due to σ-aromaticity of the cluster framework. Calculated and observed 207Pb NMR chemical shifts and 207Pb–xM J-couplings (xM=59Co, 103Rh, 193Ir) are in excellent agreement and DFT analysis shows that the variations of 207Pb NMR chemical shifts for the [M@Pb12]2, 3− ions (M=Co, Rh, Ir, Ni, Pd, Pt) are mainly governed by the perpendicularly oriented σ11 component of the chemical shift anisotropy tensor. The laser desorption ionization time-of-flight (LDI-TOF) mass spectra contain the molecular ions as well as several new gas phase clusters derived from the parents. The DFT-minimized structures of these ions are described. 相似文献
65.
66.
Using large scale Monte Carlo simulations, the ordering of the three-dimensional three state Potts ferromagnet exposed to
random fields is investigated. Studies of the order parameter probability distribution and of various of its moments suggest
that the order of the transition depends on the strength of the random field: i.e., the first order transition of the pure
ferromagnetic model persists for weak random fields, but turns into a second order transition for a range of random fields
of medium strength. For large random fields the transition seems to be first order again. In this range large domains of strongly
aligned Potts spins occur already in the disordered phase and the associated slow relaxation hampers significantly the Monte
Carlo study of thermodynamic equilibrium phenomena. These results are discussed in the light of current theoretical concepts.
Possible applications to experiments on diluted anisotropic molecular crystals and orientational glasses are briefly mentioned. 相似文献
67.
68.
69.
Leporatti S Sczech R Riegler H Bruzzano S Storsberg J Loth F Jaeger W Laschewsky A Eichhorn S Donath E 《Journal of colloid and interface science》2005,281(1):101-111
Colloidal probe microscopy was employed to study forces between cellulose surfaces upon addition of a series of cationic copolymers in aqueous solution, as model compounds for wet strength agents. The content of quaternary ammonium groups and primary amines was systematically varied in the cationic polymers, to distinguish between the importance of electrostatical and H-bonding effects. Cellulose microspheres were glued at the apex of tipless microfabricated cantilevers and used as colloidal probes. Ultra thin cellulose films and cellulose fibres were employed as model surfaces. The cellulose films of a thickness of about 5 nm were spin-coated from cellulose solution onto silicon substrates. The root-mean-square-roughness (RMS) was 0.3-0.8 nm. The cationic model polymers were compared to Servamine, a polymer employed as standard wet strength resin in papermaking industries. Force versus separation measurements showed a detailed picture of adhesion and contact breaking. Relatively strong adhesion of the order of 0.3 mJ/m(2) was observed with Servamine within a range of approximately 10 nm. At larger distances weak bond breaking and elastic chain pulling were identified. When approaching the surface one to two small jump-in's possibly related to strong binding of Servamine and subsequent attraction could be found in the case of Servamine. In contrast, all the model copolymers showed only a weak adhesion of 8-30 micro/m(2), i.e., an order of magnitude less than that of Servamine and subsequent elastic rupture domains. The contour length, persistence length and characteristic rupture distances were calculated by means of applying the WLC model. Measurements against cellulose fibres obtained from the production process proved the relevance of the model systems. 相似文献
70.
R. Klöcking U. Eichhorn und T. Blumöhr 《Fresenius' Journal of Analytical Chemistry》1978,292(5):408-411
Zusammenfassung Es wird eine Methode zum Nachweis von Stoffen vom Huminsäuretyp (natürliche und synthetische Phenolkörperpolymerisate) im Blutserum beschrieben. Die Abtrennung der freien Huminsäuren von Begleitsubstanzen erfolgt durch Polyacrylamidgelelektrophorese an einem 7,5 %igen Trenngel pH 8.9; die Trenndauer beträgt 30 min. Nach Fixieren der Gele in einer 10%igen Blei(II)-acetatlösung werden die Huminsäuren durch Anfärben mit 0,2% Alcianblau 8GS sichtbar gemacht. Eine quantitative Auswertung der Disk-Elektrophoresen ist durch direkte photometrische Messung der Gele bei 560 nm möglich. Zur Differenzierung von sauren Mucopolysacchariden (z.B. Heparin) und Stoffen vom Huminsäuretyp wird die Reaktion mit FeCl3/K3 [Fe(CN)6] und/oder eine Vorbehandlung der Proben mit 1 N KMnO4 empfohlen.
A disc electrophoretic method for detecting humic acid-type substances in blood serum
Summary A method for detecting humic acid-type substances (naturally occurring as well as synthetic polymerizates of phenolic compounds) in blood serum is described. The separation of humic acids from nonhumic substances is carried out by polyacrylamide gel electrophoresis in a 7.5% separation gel pH 8.9 during a separation time of 30 min. After having been fixed with 10% lead(II) acetate the humic acids are stained with 0.2% Alcian blue 8GS. A quantitative evaluation of the disc electrophoreses is possible by direct photometric measurement of the gels at 560 nm. For discriminating between heparin and humic acid-type substances the reaction with FeCl3/K3 [Fe(CN)6] and/or the pretreatment of the samples with 1 N KMnO4 is recommended.
Dank. Frau Christa Kupke und Frau Christa Rothmann danken wir für wertvolle technische Assistenz. 相似文献