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排序方式: 共有113条查询结果,搜索用时 140 毫秒
51.
Carl-Johan Carling Jason Olejniczak Alexandra Foucault-Collet Guillaume Collet Mathieu L. Viger Viet Anh Nguyen Huu Brendan M. Duggan Adah Almutairi 《Chemical science》2016,7(3):2392-2398
We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease. 相似文献
52.
J. R. Duggan 《Analytical and bioanalytical chemistry》1884,23(1):531-532
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J. R. Duggan 《Fresenius' Journal of Analytical Chemistry》1883,22(1):299
Ohne Zusammenfassung 相似文献
55.
Dr. Brendan M. Duggan Reiko Cullum Prof. William Fenical Luis A. Amador Prof. Abimael D. Rodríguez Dr. James J. La Clair 《Angewandte Chemie (International ed. in English)》2020,59(3):1144-1148
The discovery of biologically active small molecules requires sifting through large amounts of data to identify unique or unusual arrangements of atoms. Here, we develop, test and evaluate an atom‐based sort to identify novel features of secondary metabolites and demonstrate its use to evaluate novelty in marine microbial and sponge extracts. This study outlines an important ongoing advance towards the translation of autonomous systems to identify, and ultimately elucidate, atomic novelty within a complex mixture of small molecules. 相似文献
56.
Mark T McAuley Rose Anne Kenny Thomas BL Kirkwood Darren J Wilkinson Janette JL Jones Veronica M Miller 《BMC neuroscience》2009,10(1):26
Background
The hippocampus is essential for declarative memory synthesis and is a core pathological substrate for Alzheimer's disease (AD), the most common aging-related dementing disease. Acute increases in plasma cortisol are associated with transient hippocampal inhibition and retrograde amnesia, while chronic cortisol elevation is associated with hippocampal atrophy. Thus, cortisol levels could be monitored and managed in older people, to decrease their risk of AD type hippocampal dysfunction. We generated an in silicomodel of the chronic effects of elevated plasma cortisol on hippocampal activity and atrophy, using the systems biology mark-up language (SBML). We further challenged the model with biologically based interventions to ascertain if cortisol associated hippocampal dysfunction could be abrogated. 相似文献57.
Substituted cyclodextrins (CDs) have many applications, but synthetic challenges have limited the derivatives that can routinely be accessed. In particular, although there is considerable interest in selective derivatization at the 2- and 3-hydroxyls on the secondary face, since bulky guest molecules are most likely to project through this larger aperture, syntheses of such derivatives have required arduous procedures that afford poor yields, limiting their accessibility and utility. We address this challenge via synthetic strategies that allow facile creation of diverse libraries of water-soluble mono-3-substituted-β-cyclodextrins, via the commercially available mono-3-amino-β-cyclodextrin. The power of these strategies is confirmed through synthesis of twenty water-soluble cyclodextrin analogues with amide, thioureas or urea linkers, using one-pot reactions producing ≥55% yields and purifications that do not require chromatography. This work opens new possibilities for the design of selective host molecules for use in supramolecular chemistry, chemical separations, pharmaceutical formulations, and calibration of molecular simulations. 相似文献
58.
P. Dawson G. Duggan H.I. Ralph K. Woodbridge G.W. t Hooft 《Superlattices and Microstructures》1985,1(3):231-235
We have combined measured 5K excitonic absorption peaks with calculations of the confined particle states to determine the band offsets in GaAs(AlGa)As quantum well heterostructures. Our observations are best fitted with a conduction band-valence band split of about 75:25. This contrasts with the currently accepted value of 85:15 and the recently proposed value of 60:40. 相似文献
59.
The process of non-radiative interface recombination is considered for quantum well heterostructures. Simple model calculations indicate that, contrary to previous suggestions, the quantum effects do not cause a large reduction in the effective interface recombination velocity, Seff. In fact, for the same interface quality, quantum effects cause an increase in Seff. 相似文献
60.