Synthesis of [1,2,3]Triazolo[5,1-a]isoquinoline Derivatives via a Selective Cascade Cyclization Sequence of 1,2-bis(Phenylethynyl)benzene Derivatives

A direct, concise, synthetic method for the generation of [1,2,3]triazolo[5,1-a]isoquinoline derivatives, using a selective cascade cyclization of unsymmetrical substituted 1,2-bis(phenylethynyl)benzene derivatives with NaN₃, has been developed. The reaction gave different substituted [1,2,3]triazolo[5,1-a]isoquinolines in moderate to good yields. It was found that the substituents on the alkynes were important for the selectivities of the cascade cyclization sequences.     

Atmospheric degradation mechanisms of a simulant organophosphorus pesticide isopropyl methyl methylphosphonate: A theoretical consideration

Calculations using density functional theory were performed to explore the mechanisms for atmospheric degradation of isopropyl methyl methylphosphonate (IMMP). The potential energy surface profiles for OH‐initiated reaction of IMMP were constructed, and all possible degradation channels were considered. Rate constants were further calculated using transition state theory. It was established from these calculations that H‐abstractions from alkyl groups have much lower energy barriers than substitutions of alkoxyl groups, and four possible H‐abstraction channels are competitive. Investigations into the secondary reactions under the presence of O₂/NO were also performed. It is shown that O₂ addition, reaction of peroxide radicals with NO to form RO radicals, and removal of ·RO are the major degradation pathways for alkyl radicals. Four selected products, CH₃OP(O)(CH₃)OC(O)CH₃, CH₃OP(O)(O)CH₃, (CH₃)₂CHOP(O)(CH₃)OH, and (CH₃)₂CHOP(O)(CH₃)OCH?O, are predicted to be the major products in this study. © 2013 Wiley Periodicals, Inc.     

The electronic structures and charge transfer properties of tetra(naphthalene‐dione)porphyrins and tetra(naphthalene‐dithione)porphyrins as dye‐sensitized solar cell skeleton

The p‐π conjugation of tetra(naphthalene‐dione)porphyrins and tetra(naphthalene‐dithione)porphyrins is clarified on the basis of density functional theory studies. When carbonyl/thionyl is introduced, π bonds on the molecular skeleton become strong–weak alternated, and the conjugation transforms from “benzene‐type” to “butadiene‐type.” The unidirectional photon‐induced current associated with the p‐π conjugation enables the light‐harvesting efficiency of this kind of molecular skeleton reaches 90% in the range of 300–800 nm. Therefore, these compounds are ideal alternative for panchromatic dye‐sensitized solar cells. © 2013 Wiley Periodicals, Inc.     

An Efficient Synthesis of New Dispiropyrrolidine Derivatives via Three‐Component 1,3‐Dipolar Cycloaddition Reaction

A series of new dispiropyrrolidine derivatives were synthesized via the three‐component 1,3‐dipolar cycloaddition reaction of azomethine ylides generated in situ by the decarboxylative condensation of acenaphthenequinone and sarcosine or l ‐thioproline with 5‐benzylidene‐1,3‐dimethylpyrimidine‐2,4,6‐trione. The structures of the products were identified by IR, ¹H‐NMR, and HRMS spectra.     

Extraction of tributyltin by magnetic molecularly imprinted polymers

We have prepared core-shell magnetic molecularly imprinted polymer nanoparticles for recognition and extraction of tributyl tin (TBT). The use of particles strongly improves the imprinting effect and leads to fast adsorption kinetics and high adsorption capacities. The functional monomer acrylamide was grafted to the surface of Fe₃O₄ nanospheres in two steps, and MIP layers were then formed on the surface by creating a MIP layer on the surface consisting of poly(ethyleneglycol dimethacrylate) with a TBT template. The particles were characterized in terms of morphological, magnetic, adsorption, and recognition properties. We then have developed a method for the extraction of TBT from spiked mussel (Mytilidae), and its determination by liquid chromatography-tandem mass spectrometry. The method has a limit of detection of 1.0 ng?g^?1 (n?=?5) of TBT, with a linear response between 5.0 and 1,000 ng?g^?1. The proposed method was successfully applied to the determination of trace TBT in marine food samples with recoveries in the range of 78.3–95.6 %.

Electrochemical sensing of hydrogen peroxide using metal nanoparticles: a review

We are reviewing the state of electrochemical sensing of H₂O₂ based on the use of metal nanoparticles. The article is divided into subsections on sensors based on nanoparticles made from Ag, Pt, Pd, Cu, bimetallic nanoparticles and other metals. Some sensors display high sensitivity, fast response, and good stability. The review is subdivided into sections on sensors based on heme proteins and on nonenzymatic sensors. We also discussed the challenges of nanoscaled sensors and their future aspects.

DNAzyme based electrochemical sensors for trace uranium

We have developed a uranyl-specific DNAzyme that was immobilized on the surface of a gold electrode to give a highly sensitive and selective biosensor for uranyl ion. The typical DNAzyme system consisted of the RNA (rA) as the substrate (ADNA), and the other strand is the enzyme (TDNA) with a ferrocene (Fc). The presence of uranyl ion induces the cleavage of the DNA substrate strand at the rA position to form two fragments. The Fc unit thereby is released from the surface of the electrode, and this results in a decreased peak current. This electrochemical biosensor has a dynamic range from 2 nM to 14 nM of uranyl ion, with a detection limit at 1 nM. It exhibits high sensitivity and excellent selectivity over other metal ions, and thus represents a promising technique for simple, fast, on-site, and real-time electrochemical sensing of UO₂(II) ion. It also serves as a guide in choosing different methods for designing electrochemical sensors for other metal ions.

Asymmetric Synthesis XIV: TiCl(Oipr)3-Promoted Asymmetric Coupling Reaction of D-Camphor Ketimine Anion

Optically active 1, 2-Diphenylethylendiamine(9) is obtained by asymmetric oxidative coupling reaction of d-camphor ketimine anion (4). Among various oxidating agents, TiCl(Oipr)₃ is better than l₂, Br₂, CuCl₂, FeCl₃ and BrCH₂CH₂Br.     

Reductive Coupling of Aldehydes,Ketones and Aroyl Chlorides Induced by LVT Prepared from TiCl4/Al System

Aluminium powder has been used to reduce titanium tetrachloride to generate the low valent titanium (LVT)reagent which can induce the reductive coupling of aldehydes and ketones to form the corresponding pinacols or olefins. However, arylsulfonyl chlorides will give diaryldisulfides under the same condition.     

Synthesis,Structures, Luminescent and Magnetic Properties of Heterometallic 5p‐4f Compounds with Ethylenediaminetetra­acetate

A series of heterometallic Ln^III–Sb^III edta‐containing compounds with the formulas [Sb₂(edta)₂Ln]NO₃ · nH₂O [edta = ethylenediaminetetraacetate; Ln = Eu, n = 7 ( 1 ); Gd, n = 7.5 ( 2 ) and Tb, n = 8 ( 3 )] were synthesized and characterized by elemental analyses (EA), powder X‐ray diffraction (PXDP), Fourier transform infrared spectroscopy (FT‐IR), and thermogravimetric analyses (TGA). Their fluorescence and magnetic properties were also studied. The thermal analysis demonstrates the compounds formation of the antimony, lanthanide ions, and edta^4– ligands. FT‐IR spectra reveal that the antimony and lanthanide ions are connected through the carboxylate bridges. The studies of luminescence properties show that compounds 1 and 3 exhibit typical luminescence in the visible region. Furthermore, magnetic properties reveal compounds 2 and 3 have weak ferromagnetic behavior.