A computational study on the capability of borane‐cyclic boryl anion adducts to act as hydrogen atom donors

According to our theoretical approaches, a cyclic boryl anion can act as a Lewis base like its isoelectronic counterpart N‐heterocyclic carbene, reducing the homolytic bond dissociation energy of B? H in BH₃. However, the donating efficiency is affected by the counter cation in both gas phase and nonpolar solvents. Moreover, we also predict the seven‐membered ring boryl anion 5 , although it has not yet synthesized, to be the most efficient reagent to reduce the bond dissociation energy of a B? H bond in BH₃. This study may thus pave another avenue toward Lewis base induced hydrogen atom abstraction in BH₃. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010     

Potentiometric and voltammetric polymer lab chip sensors for determination of nitrate, pH and Cd(II) in water

Microparticles are phospholipid vesicles shed mostly in biological fluids, such as blood or urine, by various types of cells, such as red blood cells (RBCs), platelets, lymphocytes, endothelial cells. These microparticles contain a subset of the proteome of their parent cell, and their ready availability in biological fluid has raised strong interest in their study, as they might be markers of cell damage. However, their small size as well as their particular physico-chemical properties makes them hard to detect, size, count and study by proteome analysis. In this review, we report the pre-analytical and methodological caveats that we have faced in our own research about red blood cell microparticles in the context of transfusion science, as well as examples from the literature on the proteomics of various kinds of microparticles.     

Iron-facilitated direct oxidative C-H transformation of allylarenes or alkenes to alkenyl nitriles

This paper describes the first direct approach to alkenyl nitriles from allylarenes or alkenes facilitated by an inexpensive homogeneous iron catalyst. Three C-H bond cleavages occur under the mild conditions during this process. Mechanistic studies indicate that the cleavage of the allyl C(sp(3))-H bond is involved in the rate-determining step. This observation may provide an opportunity to achieve C(sp(3))-H functionalization catalyzed by an iron catalyst.     

Platinum(II)-catalyzed intramolecular cyclization of alkynylbenzonitriles: synthesis of 1-alkoxyisoquinolines and isoquinolones

A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6-endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) in various alcohols at 65-90 °C is described for the first time.     

Interaction of a solid supported liquid-crystalline phospholipid membrane with physical vapor deposited metal atoms

A metal (Ag, Au, Pd, Sn, Bi, In, Co, Al) layer directly deposited onto a liquid-crystalline lipid membrane resulted in different morphologies, ranging from a monolayer of discrete particles to a continuous film, depending on the metal's oxidation tendency.     

FTIR studies of CO adsorption on Al2O3- and SiO2-supported Ru catalysts

The adsorption of CO on Al2O3- and SiO2-supported Ru catalysts has been investigated through FTIR spectroscopy. Deconvolution of the spectra obtained reveals the presence of 11 distinct bands in the case of Ru/Al2O3 and 10 bands in the case of Ru/SiO2, which were assigned to different carbonyl species adsorbed on reduced as well as partially oxidized Ru sites. Although most of these bands on both supports are similar, they exhibit substantial differences in terms of stability. In general, the analogous CO species on Ru/Al2O3 are adsorbed stronger than those on Ru/SiO2, with the most stable species observed being a dicarbonyl adsorbed on metallic Ru (i.e., Ru0(CO)2). Following sintering of the Ru, the ratio of multicarbonyl to monocarbonyl adsorption is reduced substantially because of the lack of isolated sites or small Ru clusters that enable the formation of multicarbonyl species via oxidative disruption. Finally, in the presence of O2, the main features observed correspond to monocarbonyl, dicarbonyl, and tricarbonyl species adsorbed on partially oxidized Run+. The intensities of all bands decrease drastically at temperatures above 210 degrees C because of the onset of CO oxidation, which results in substantially reduced surface coverage.     

Global weak solutions to a generalized Benjamin-Bona-Mahony-Burgers equation

The existence of global weak solutions for a generalized Benjamin-Bona-MahonyBurgers equation is established in the space C([0, ∞) × R) ∩ L~∞([0, ∞); H1(R)) under the condition that its initial value belongs to the space H1(R). A one-sided super bound estimate and a space-time higher-norm estimate on the first order derivatives of the solution with respect to the space variable are derived to prove the existence.     

Application of an LC–MS/MS Method for the Simultaneous Quantification of Homovanillic Acid and Vanillylmandelic Acid for the Diagnosis and Follow-Up of Neuroblastoma in 357 Patients

Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are end-stage metabolites of catecholamine and are clinical biomarkers for the diagnosis of neuroblastoma. For the first time in Korea, we implemented and validated a liquid chromatography tandem mass spectrometry (LC–MS/MS) assay to measure urinary concentrations of HVA and VMA according to Clinical and Laboratory Standards Institute guidelines. Our LC–MS/MS assay with minimal sample preparation was validated for linearity, lower limit of detection (LOD), lower limit of quantification (LLOQ), precision, accuracy, extraction recovery, carryover, matrix effect, and method comparison. A total of 1209 measurements was performed to measure HVA and VMA in spot urine between October 2019 and September 2020. The relationship between the two urinary markers, HVA and VMA, was analyzed and exhibited high agreement (89.1% agreement, kappa’s k = 0.6) and a strong correlation (Pearson’s r = 0.73). To our knowledge, this is the first study to utilize LC–MS/MS for simultaneous quantitation of spot urinary HVA and VMA and analyze the clinical application of both markers on a large scale for neuroblastoma patients.