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41.
Jos B. de Araújo-Neto Maria M. C. da Silva Cícera D. de M. Oliveira-Tintino Iêda M. Begnini Ricardo A. Rebelo Luiz E. da Silva Sandro L. Mireski Michele C. Nasato Maria I. L. Krautler Jaime Ribeiro-Filho Abolghasem Siyadatpanah Polrat Wilairatana Henrique D. M. Coutinho Saulo R. Tintino 《Molecules (Basel, Switzerland)》2021,26(23)
The search for new antibacterial agents has become urgent due to the exponential growth of bacterial resistance to antibiotics. Nitrogen-containing heterocycles such as 1,8-naphthyridine derivatives have been shown to have excellent antimicrobial properties. Therefore, the purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the following compounds: 7-acetamido-1,8-naphthyridin-4(1H)-one and 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide. The antibiotic-modulating activity was analyzed using subinhibitory concentrations (MIC/8) of these compounds in combination with norfloxacin, ofloxacin, and lomefloxacin. Multi-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were used in both tests. Although the compounds had no direct antibacterial activity (MIC ≥ 1.024 µg/mL), they could decrease the MIC of these fluoroquinolones, indicating synergism was obtained from the association of the compounds. These results suggest the existence of a structure–activity relationship in this group of compounds with regard to the modulation of antibiotic activity. Therefore, we conclude that 1,8-naphthyridine derivatives potentiate the activity of fluoroquinolone antibiotics against multi-resistant bacterial strains, and thereby interesting candidates for the development of drugs against bacterial infections caused by multidrug resistant strains. 相似文献
42.
An eco‐friendly protocol for the synthesis of azobenzene dyes by oxidative coupling of primary aromatic amines is reported. As efficient biocatalytic systems, CotA laccase and CotA laccase/ABTS (2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)) enable the oxidation of various substituted anilines, in aqueous medium, ambient atmosphere and under mild reaction conditions of pH and temperature. A series of azobenzene dyes were prepared in good to excellent yields in an one‐pot reaction. A mechanistic proposal for the formation of the azo derivatives is presented. Our strategy offers an alternative approach for the direct synthesis of azobenzene dyes, avoiding the harsh conditions generally required for most of the traditional synthetic methods. 相似文献
43.
Juan Campos Alessandro Margheri Carlota Rebelo 《Journal of Dynamics and Differential Equations》2018,30(4):1837-1854
In this paper we consider an endemic SI model with standard incidence and prove the existence of monotone and unimodal travelling waves with large velocity. The birth and death rates can be quite general. When the birth rate is constant we prove the existence of two kinds of travelling waves and give the minimal velocity of one of the types. 相似文献
44.
Let R be a ring. An R-module X is called c-injective if, for every closed submodule L of every R-module M, every homomorphism from L to X lifts to M. It is proved that if R is a Dedekind domain then an R-module X is c-injective if and only if X is isomorphic to a direct product of homogeneous semisimple R-modules and injective R-modules. It is also proved that a commutative Noetherian domain R is Dedekind if and only if every simple R-module is c-injective. 相似文献
45.
Williams JG Tomer KB Hioe CE Zolla-Pazner S Norris PJ 《Journal of the American Society for Mass Spectrometry》2006,17(11):1560-1569
In the last decade, mass spectrometry has been employed by more and more researchers for identifying the proteins in a macromolecular complex as well as for defining the surfaces of their binding interfaces. This characterization of protein-protein interfaces usually involves at least one of several different methodologies in addition to the actual mass spectrometry. For example, limited proteolysis is often used as a first step in defining regions of a protein that are protected from proteolysis when the protein of interest is part of a macromolecular complex. Other techniques used in conjunction with mass spectrometry for determining regions of a protein involved in protein-protein interactions include chemical modification, such as covalent cross-linking, acetylation of lysines, hydrogen-deuterium exchange, or other forms of modification. In this report, both limited proteolysis and chemical modification were combined with several mass spectrometric techniques in efforts to define the protein surface on the HIV core protein, p24, recognized by two different monoclonal human antibodies that were isolated from HIV+ patients. One of these antibodies, 1571, strongly inhibits the CD4+ T cell proliferative response to a known epitope (PEVIPMFSALSEGATP), while the other antibody, 241-D, does not inhibit as strongly. The epitopes for both of these antibodies were determined to be discontinuous and localized to the N-terminus of p24. Interestingly, the epitope recognized by the strongly inhibiting antibody, 1571, completely overlaps the T cell epitope PEVIPMFSALSEGATP, while the antibody 241-D binds to a region adjacent to the region of p24 recognized by the antibody 1571. These results suggest that, possibly due to epitope competition, antibodies produced during HIV infection can negatively affect CD4+ T cell-mediated immunity against the virus. 相似文献
46.
Catarina IV Ramos Flávio Figueira Marcelo D Polêto Francisco ML Amado Hugo Verli João PC Tomé M Graça PMS Neves 《Journal of mass spectrometry : JMS》2016,51(5):342-349
Electrospray mass spectrometry/mass spectrometry was used to investigate the gas‐phase properties of protonated expanded porphyrins, in order to correlate those with their structure and conformation. We have selected five expanded meso‐pentafluorophenyl porphyrins, respectively, a pair of oxidized/reduced fused pentaphyrins (22 and 24 π electrons), a pair of oxidized/reduced regular hexaphyrins (26 and 28 π electrons) and a regular doubly N‐fused hexaphyrin (28 π electrons). The gas‐phase behavior of the protonated species of oxidized and reduced expanded porphyrins is different. The oxidized species (aromatic Hückel systems) fragment more extensively, mainly by the loss of two HF molecules. The reduced species (Möbius aromatic or Möbius‐like aromatic systems) fragment less than their oxidized counterparts because of their increased flexibility. The protonated regular doubly fused hexaphyrin (non‐aromatic Hückel system) shows the least fragmentation even at higher collision energies. In general, cyclization through losses of HF molecules decreases from the aromatic Hückel systems to Möbius aromatic or Möbius‐like aromatic systems to non‐aromatic Hückel systems and is related to an increase in conformational distortion. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
47.
Tariq M Freire MG Saramago B Coutinho JA Lopes JN Rebelo LP 《Chemical Society reviews》2012,41(2):829-868
Some of the most active scientific research fronts of the past decade are centered on ionic liquids. These fluids present characteristic surface behavior and distinctive trends of their surface tension versus temperature. One way to explore and understand their unique nature is to study their surface properties. This critical review analyses most of the surface tension data reported between 2001 and 2010 (187 references). 相似文献
48.
Ramos CI Santana-Marques MG Ferrer-Correia AJ Barata JF Tomé AC Neves MG Cavaleiro JA Abreu PE Pereira MM Pais AA 《Journal of mass spectrometry : JMS》2012,47(4):516-522
Two new isomeric aminomethyl corrole derivatives of [5,10,15-tris(pentafluorophenyl)corrolato]gallium(III) were synthesized with pyridine (py) molecules as axial ligands. When investigated by electrospray ionization mass spectrometry, in the positive and the negative ion modes, these compounds showed an unusual gas-phase behavior that could be used for their differentiation. In the positive ion mode, the differentiation was achieved through the formation of diagnostic fragment ions formed from [M-py?+?H](+) precursors, by (CH(3) )(2) NH and HF losses. An unusual addition of water to the main fragment ions provides an alternative route for isomer identification. Semi-empirical calculations were performed to elucidate the structures and stabilities of the main ionic species formed in the positive ion mode. In the negative ion mode isomer discrimination is accomplished via the fragmentation of the methoxide adduct ions [M-py?+?CH(3) O](-) through (CH(3) )(2) N(.) and HF losses. 相似文献
49.
Catarina I. V. Ramos M. Graça Santana‐Marques A. J. Ferrer‐Correia Joana F. B. Barata Augusto C. Tomé M. Graça P. M. S. Neves J. A. S. Cavaleiro Paulo E. Abreu Mariette M. Pereira Alberto A. C. C. Pais 《Journal of mass spectrometry : JMS》2012,47(4):516-522
Two new isomeric aminomethyl corrole derivatives of [5,10,15‐tris(pentafluorophenyl)corrolato]gallium(III) were synthesized with pyridine (py) molecules as axial ligands. When investigated by electrospray ionization mass spectrometry, in the positive and the negative ion modes, these compounds showed an unusual gas‐phase behavior that could be used for their differentiation. In the positive ion mode, the differentiation was achieved through the formation of diagnostic fragment ions formed from [M‐py + H]+ precursors, by (CH3)2NH and HF losses. An unusual addition of water to the main fragment ions provides an alternative route for isomer identification. Semi‐empirical calculations were performed to elucidate the structures and stabilities of the main ionic species formed in the positive ion mode. In the negative ion mode isomer discrimination is accomplished via the fragmentation of the methoxide adduct ions [M‐py + CH3O]‐ through (CH3)2 N. and HF losses. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
50.
Catarina I. V. Ramos João P. C. Tomé M. G. Santana‐Marques 《Journal of mass spectrometry : JMS》2012,47(2):173-179
The adduct ions of two tetramolecular G‐quadruplexes formed from the d(TGGGGT) and d(TTGGGGGT) single strands with a group of cationic porphyrins, with different charges and substituents, and one neutral porphyrin, were investigated by ESI‐MS and ESI‐MS/MS in the negative ion mode. Formation of [Q + nNH4++Pp+‐(z + n + p)H+]z‐ adduct ions (where Q = quadruplex, n = number of quartets minus 1, P = porphyrin and p+ =0,1,2,3,4) indicates that the porphyrins are bound outside the quadruplexes providing an additional stabilization to those structures. The fragmentation pathways of the [Q + nNH4++Pp+‐(z + n + p)H+]z‐ adduct ions depend on the number of positive charges (p+) of the porphyrins and on the overall complex charge (z‐), but do not show a significant dependence on the type of the substituent groups in the porphyrins. Formation of the ‘unfilled’ ions [Q + Pp+‐(z + p)H+]z‐ predominates for porphyrins with a higher number of positive charges. Strand separation with the formation of [T + Pp+‐(z‐2 + p)H+](z‐2)‐ and (SS‐2H+)2‐ ions, where T = [d(TG4T)]3 and [d(T2G5T)]3 and SS = d(TG4T) and d(T2G5T) is only observed for the complexes with a higher overall negative charge. Porphyrin loss with the formation of [Q + nNH4+‐(z + n)H+]z‐ ions occurs predominantly for the neutral and monocharged porphyrins. The predominant formation of the ‘unfilled’ ions, [Q + Pp+‐(z + n)H+]z‐, for porphyrins with a higher number of charges shows that these porphyrins can prevent strand separation and preserve, at least partially, the quadruplex structure. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献