全文获取类型
收费全文 | 1987篇 |
免费 | 132篇 |
国内免费 | 18篇 |
专业分类
化学 | 1552篇 |
晶体学 | 6篇 |
力学 | 21篇 |
数学 | 348篇 |
物理学 | 210篇 |
出版年
2024年 | 2篇 |
2023年 | 20篇 |
2022年 | 9篇 |
2021年 | 34篇 |
2020年 | 57篇 |
2019年 | 69篇 |
2018年 | 34篇 |
2017年 | 27篇 |
2016年 | 70篇 |
2015年 | 55篇 |
2014年 | 69篇 |
2013年 | 97篇 |
2012年 | 129篇 |
2011年 | 136篇 |
2010年 | 66篇 |
2009年 | 77篇 |
2008年 | 137篇 |
2007年 | 143篇 |
2006年 | 130篇 |
2005年 | 131篇 |
2004年 | 107篇 |
2003年 | 88篇 |
2002年 | 92篇 |
2001年 | 37篇 |
2000年 | 28篇 |
1999年 | 31篇 |
1998年 | 19篇 |
1997年 | 30篇 |
1996年 | 27篇 |
1995年 | 24篇 |
1994年 | 25篇 |
1993年 | 23篇 |
1992年 | 7篇 |
1991年 | 20篇 |
1990年 | 7篇 |
1989年 | 11篇 |
1988年 | 8篇 |
1986年 | 3篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 9篇 |
1980年 | 6篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1974年 | 5篇 |
1973年 | 1篇 |
1951年 | 1篇 |
排序方式: 共有2137条查询结果,搜索用时 31 毫秒
991.
Fenske T Korth HG Mohr A Schmuck C 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(3):738-755
Supramolecular nanoassemblies are gaining increasing importance as promising new materials with considerable potential for novel and promising applications. Within supramolecular nanoassemblies the connectivity of the monomeric units is based on reversible noncovalent interactions, like van der Waals interactions, hydrogen bonding, or ionic interactions. As the strength of these interactions depends on the molecular surrounding, the formation of nanoassemblies in principle can be controlled externally by changing the environment and/or the molecular shape of the underlying monomer. This way it is not only possible to switch the self-assembly on or off, but also to change between different aggregation states. In this minireview we present some recent selected approaches to supramolecular stimuli-responsive nanoassemblies. 相似文献
992.
Carsten Dingels Dr. Frederik Wurm Dr. Manfred Wagner Prof. Dr. Harm‐Anton Klok Prof. Dr. Holger Frey 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(52):16828-16835
The covalent attachment of poly(ethylene glycol) (PEG) to therapeutically active proteins (PEGylation) has become an important method to deal with the pharmacological difficulties of these polypeptides, such as short body‐residence times and immunogenicity. However, the derivatives of PEG used for PEGylation lack further functional groups that would allow the addition of targeting or labeling moieties. Squaric acid diethyl ester was used for the chemoselective single‐step activation of poly(ethylene glycol)s into the respective ester amides. The resultant selective protein‐reactive poly(ethylene glycol)s were investigated with respect to their selectivity towards amino acid residues in bovine serum albumin (as a model protein). The presented procedure relies on a robust two‐step protocol and was found to be selective towards lysine residues; the activated polyethers are efficient and stoichiometric PEGylation agents with a remarkable hydrolytic stability over a period of several days. By adjusting the pD value of the conjugation mixture, the chemoselectivity of the activated PEGs towards the α‐ and ε‐amino groups of lysine methyl ester was effectively changed. 相似文献
993.
The electromagnetic field in a typical geometry of the Casimir effect is described in the Schwinger–Keldysh formalism. The main result is the photon distribution function (Keldysh Green function) in any stationary state of the field. A two‐plate geometry with a sliding interface in local equilibrium is studied in detail, and full agreement with the results of Rytov fluctuation electrodynamics is found. 相似文献
994.
Carsten Schultz-Fademrecht Olaf Kinzel István E. Markó Silvia Pesci Philip Jones 《Tetrahedron》2009,65(45):9487-5437
An efficient and general synthesis of homochiral α-amino substituted bromo-heteroaromatics B using a diastereoselective 1,2-addition has been developed. The obtained heteroaromatic intermediates allow for a rapid two-dimensional exploration of a new series of histone deacetylase inhibitors, through Suzuki-Miyaura cross-coupling reactions for the introduction of a second aromatic element, followed by global deprotection and derivatization of the amino group. 相似文献
995.
Andreas Bertsch Andreas Leinenbach Anton Pervukhin Markus Lubeck Ralf Hartmer Carsten Baessmann Yasser Abbas Elnakady Rolf Müller Sebastian Böcker Christian G. Huber Oliver Kohlbacher 《Electrophoresis》2009,30(21):3736-3747
De novo sequencing of peptides using tandem MS is difficult due to missing fragment ions in the spectra commonly obtained after CID of peptide precursor ions. Complementing CID spectra with spectra obtained in an ion‐trap mass spectrometer upon electron transfer dissociation (ETD) significantly increases the sequence coverage with diagnostic ions. In the de novo sequencing algorithm CompNovo presented here, a divide‐and‐conquer approach was combined with an efficient mass decomposition algorithm to exploit the complementary information contained in CID and ETD spectra. After optimizing the parameters for the algorithm on a well‐defined training data set obtained for peptides from nine known proteins, the CompNovo algorithm was applied to the de novo sequencing of peptides derived from a whole protein extract of Sorangium cellulosum bacteria. To 2406 pairs of CID and ETD spectra contained in this data set, 675 fully correct sequences were assigned, which represent a success rate of 28.1%. It is shown that the CompNovo algorithm yields significantly improved sequencing accuracy as compared with published approaches using only CID spectra or combined CID and ETD spectra. 相似文献
996.
Jin Hu Jiangshui Luo Peter Wagner Olaf Conrad Carsten Agert 《Electrochemistry communications》2009,11(12):2324-2327
PEMFC operating at high temperature (100–200 °C) are expected to have significant advantages but face big challenges in the development of suitable proton exchange membranes. This communication describes novel PBI-OO/PFSA blend membranes, which facilitate proton conduction under anhydrous conditions based on a “proton donor–proton acceptor” concept. The proton conductivity of the blends under anhydrous conditions exceeded that of PFSA by a factor of 50 at ambient temperature and of 2–4 at elevated temperature. Intermolecular interaction between two polymer components was investigated by FT-IR spectroscopy. After incorporation of inorganic electron-deficient compounds (BN nanoparticles), the anhydrous proton conductivity of the composites was higher than that of the bare PFSA by three orders of magnitude at ambient temperature and more than one order of magnitude at 140 °C. 相似文献
997.
The thermal behavior of AgNCO (silver isocyanate) has been studied via thermal analysis, optical spectroscopy, X-ray powder diffraction and transmission electron microscopy. Upon quenching the high temperature polymorph (HT-AgNCO) to room temperature, a new modification has been obtained (q-AgNCO). Its crystal structure was solved from X-ray powder diffraction data and refined by the Rietveld method (Pmmn (no. 59), a = 3.579(3) Å, b = 5.777(4) Å, c = 5.807(2) Å, V = 120.08(3) Å3, Z = 2, T = 295 K). The structure consists of chains of Ag+ ions bridged by isocyanate units. HT-AgNCO exists between T = 135 °C and the melting/decomposition point and exhibits virtually free rotation of the complex anions. According to preliminary single-crystal studies, HT-AgNCO (C2/m, a = 5.87 Å, b = 3.51 Å, c = 5.81 Å, ß = 105.953°, Z = 2, T = 373 K) is structurally related to α-NaN3. The crystal structures of both, HT-AgNCO and q-AgNCO have been compared with that of the room temperature modification (RT-AgNCO). The thermal behavior and the ionic conductivity of AgNCO are discussed with respect to the related compounds AgN3 and KSCN. Decomposition of AgNCO proceeds in distinct steps, as seen from TGA, and results in the formation of nanoparticles of elemental silver and an amorphous polymer consisting of C, N and O, only. 相似文献
998.
Zimmermann R Kuckling D Kaufmann M Werner C Duval JF 《Langmuir : the ACS journal of surfaces and colloids》2010,26(23):18169-18181
Streaming current measurements were performed on poly(N-isopropylacrylamid-co-carboxyacrylamid) (PNiPAAM-co-carboxyAAM) soft thin films over a broad range of pH and salt concentration (pH 2.5-10, 0.1-10 mM KCl) at a constant temperature of 22 °C. The films are negatively charged because of the ionization of the carboxylic acid groups in the repeat unit of the copolymer. For a given salt concentration, the absolute value of the streaming current exhibits an unconventional, nonmonotonous dependence on pH with the presence of a maximum at pH ~6.4. This maximum is most pronounced at low electrolyte concentration and gradually disappears with increasing salinity. Complementary ellipsometry data further reveal that the average film thickness increases by a factor of ~2.2 with increasing pH over the whole range of salt concentration examined. The larger the solution salt concentration, the lower the pH value where expansion of the hydrogel layer starts to take place. The dependence of film thickness on pH and electrolyte concentration remarkably follows that obtained for surface conductivity. The streaming current and surface conductivity results could be consistently interpreted on a quantitative basis using the theory we previously derived for the electrokinetics of charged diffuse (heterogeneous) soft thin films complemented here by the derivation of a general expression for the surface conductivity of such systems. In particular, the maximum in streaming current versus pH is unambiguously attributed to the presence of an interphasial gradient in polymer segment density following the heterogeneous expansion of the chains within the film upon swelling with increasing pH. A quantitative inspection of the data further suggests that pK values of ionogenic groups in the film as derived from the streaming current and surface conductivity data differ by ~0.9 pH unit. Such a difference is attributed to the impact of position-dependent hydrophobicity across the film on the degree of ionization of carboxylic sites. 相似文献
999.
Jan Vogelsang Dr. Christian Steinhauer Carsten Forthmann Ingo H. Stein Britta Person‐Skegro Dr. Thorben Cordes Dr. Philip Tinnefeld Prof. Dr. 《Chemphyschem》2010,11(12):2475-2490
In recent years, a number of approaches have emerged that enable far‐field fluorescence imaging beyond the diffraction limit of light, namely super‐resolution microscopy. These techniques are beginning to profoundly alter our abilities to look at biological structures and dynamics and are bound to spread into conventional biological laboratories. Nowadays these approaches can be divided into two categories, one based on targeted switching and readout, and the other based on stochastic switching and readout of the fluorescence information. The main prerequisite for a successful implementation of both categories is the ability to prepare the fluorescent emitters in two distinct states, a bright and a dark state. Herein, we provide an overview of recent developments in super‐resolution microscopy techniques and outline the special requirements for the fluorescent probes used. In combination with the advances in understanding the photophysics and photochemistry of single fluorophores, we demonstrate how essentially any single‐molecule compatible fluorophore can be used for super‐resolution microscopy. We present examples for super‐resolution microscopy with standard organic fluorophores, discuss factors that influence resolution and present approaches for calibration samples for super‐resolution microscopes including AFM‐based single‐molecule assembly and DNA origami. 相似文献
1000.
Schichtel N Korte C Hesse D Zakharov N Butz B Gerthsen D Janek J 《Physical chemistry chemical physics : PCCP》2010,12(43):14596-14608
Multilayer samples of the type (YSZ|Sc2O3) × n with layer thicknesses between 8 nm (n=100) and 250 nm (n=5) were prepared on (0001) sapphire substrates by pulsed laser deposition (PLD). The samples were characterised using X-ray diffraction (XRD), scanning electron microscopy (HRSEM) and transmission electron microscopy (TEM/HRTEM, SAED (selected-area electron diffraction) and quantitative EELS (electron energy-loss spectroscopy)). The polycrystalline layers show a columnar microstructure, which is typical for the used preparation technique. The layers are highly textured and only one axial orientation relation is found between yttria-stabilised zirconia (YSZ), scandium oxide and the substrate: (0001) Al2O3‖(111) Sc2O3‖(111) YSZ. A preferred orientation relationship also exists for the azimuthal rotation of the crystallites, which was demonstrated by SAED, XRD pole figure measurements and fast Fourier transformation (FFT) of HRTEM micrographs. The interfaces between YSZ, Sc2O3 and the substrate are sharp and do not contain diffuse transition regions. Dislocations appear not to be arranged in regular arrays. With increasing interface density (thinner individual layers in the multilayer), the conductivity of the multilayers decreases. We relate this to the negative nominal misfit present at the YSZ|Sc2O3 interfaces (compressive stress in YSZ at the phase boundaries). This observation agrees well with the previously investigated case of YSZ|Y2O3 (A. Peters et al., Phys. Chem. Chem. Phys., 2008, 10, 4623), where tensile misfit strain was present in YSZ at the phase boundaries, leading to a conductivity increase. 相似文献