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991.
M. E. Wieder B. P. Gray P. R. Brown S. Hudson C. M. Pearce S. W. Paine L. Hillyer 《Chromatographia》2012,75(11-12):635-643
Acepromazine maleate (Sedalin?) was administered orally to six thoroughbred horses at a dose of 0.15?mg?kg?1. Urine and blood samples were collected up to 412?h post-administration. Plasma and urine were hydrolysed; plasma samples were then processed using liquid–liquid extraction and urine samples using solid-phase extraction. A sensitive tandem mass spectrometric method was developed in this study, achieving a lower limit of quantification for acepromazine of 10?pg?mL?1 in plasma and 100?pg?mL?1 in urine. Acepromazine, hydroxyethylpromazine, hydroxyacepromazine, hydroxyethylpromazine sulphoxide, hydroxyethylhydroxypromazine, dihydroxyacepromazine and dihydroxyhydroxyethylpromazine were detected in the post-administration samples. The parent drug and its metabolites were identified using a combination of UPLC–MS/MS and accurate mass measurement. Separation of the structural isomers hydroxyethylpromazine sulphoxide and hydroxyethylhydroxypromazine was another significant outcome of this work and demonstrated the advantages to be gained from investing in chromatographic method development. 相似文献
992.
The 2,2'-biphenyl-bridged bis(2-aminophenol) ligand 4,4'-di-tert-butyl-N,N'-bis(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2'-diaminobiphenyl ((t)BuClipH(4)) reacts with MoO(2)(acac)(2) to form ((t)BuClipH(2))MoO(2), where the diarylamines remain protonated and bind trans to the terminal oxo groups. This complex readily loses water on treatment with pyridine or 3,5-lutidine to form mono-oxo complexes ((t)BuClip)MoO(L), which exhibit predominantly a cis-β geometry with an aryloxide trans to the oxo group. Exchange of the pyridine ligands is rapid and takes place by a dissociative mechanism, which occurs with retention of stereochemistry at molybdenum. Oxo-free alkoxide complexes ((t)BuClip)Mo(OR)(2) are formed from ((t)BuClipH(2))MoO(2) and ROH. Treatment of NMo(O(t)Bu)(3) with (t)BuClipH(4) results in complete deprotonation of the bis(aminophenol) and formation of a dimolybdenum complex ((t)BuClip)Mo(μ-N)(μ-NH(2))Mo((t)BuClip) containing both a bridging nitride (Mo-N = 1.848 ?, Mo-N-Mo = 109.49°) and a bridging amide group. The strong π bonding of this bis(amidophenoxide) ligand allows the molybdenum center to interconvert readily among species forming three, two, one, or zero π bonds from multiply bonded ligands. 相似文献
993.
The methanolysis of the Cu(II) complex of N-acetyl-N,N-bis(2-picolyl)amine (2) was investigated by a kinetic study as a function of pH in methanol at 25 °C and computationally by DFT calculations. The active species is the basic form of the complex (3(-)), or (1:Cu(II))((-)OCH(3))(HOCH(3))), and the rate constant for its solvolysis is k(max) = 1.5 × 10(-4) s(-1). The mechanism involves Cu(II) binding to the amide N lone pair, decoupling it from >N-C═O resonance, concomitant with Cu(II):((-)OCH(3)) delivery to the adjacent >N-C═O unit, followed by Cu(II)-assisted departure of the N,N-bis(2-picolyl)amide from a tetrahedral intermediate. 相似文献
994.
Improvements in drug design have historically been centered around structure-based optimization of molecule specificity for a targeted protein, in an effort to reduce unintentional binding to other proteins and off-target effects. Although the "one-to-one" drug design strategy has been successful in impairing function of targets associated with a number of diseases, recent reports of drug promiscuity, which are a potential source of adverse reactions in patients, make a case to refine the drug design strategy such that it includes an awareness of multiple interactions from both ligand and protein perspectives. Polypharmacology and chemical biology studies are amassing interaction data at rapid rates, and the integration of such data into an interpretable model requires zooming our perspective out from the single ligand-target level to the larger network-wide level. We review some of the recent developments in systems-level research for drug design and discovery, and discuss the directions that some drug design efforts are heading toward. 相似文献
995.
Anil Khanal Yan Pan Leonid S. Brown Lars Konermann 《Journal of mass spectrometry : JMS》2012,47(12):1620-1626
Kinetic folding experiments by pulsed hydrogen/deuterium exchange (HDX) mass spectrometry (MS) are a well‐established tool for water‐soluble proteins. To the best of our knowledge, the current study is the first that applies this approach to an integral membrane protein. The native state of bacteriorhodopsin (BR) comprises seven transmembrane helices and a covalently bound retinal cofactor. BR exposure to sodium dodecyl sulfate (SDS) induces partial unfolding and retinal loss. We employ a custom‐built three‐stage mixing device for pulsed‐HDX/MS investigations of BR refolding. The reaction is triggered by mixing SDS‐denatured protein with bicelles. After a variable folding time (10 ms to 24 h), the protein is exposed to excess D2O buffer under rapid exchange conditions. The HDX pulse is terminated by acid quenching after 24 ms. Subsequent off‐line analysis is performed by size exclusion chromatography and electrospray MS. These measurements yield the number of protected backbone N–H sites as a function of folding time, reflecting the recovery of secondary structure. Our results indicate that much of the BR secondary structure is formed quite late during the reaction, on a time scale of 10 s and beyond. It is hoped that in the future it will be possible to extend the pulsed‐HDX/MS approach employed here to membrane proteins other than BR. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
996.
The general atomic and molecular electronic structure system (GAMESS) is a quantum chemistry package used in the first-principles modeling of complex molecular systems using density functional theory (DFT) as well as a number of other post-Hartree-Fock methods. Both DFT and time-dependent DFT (TDDFT) are of particular interest to the materials modeling community. Millions of CPU hours per year are expended by GAMESS calculations on high-performance computing systems; any substantial reduction in the time-to-solution for these calculations represents a significant saving in CPU hours. As part of this work, three areas for improvement were identified: (1) the exchange-correlation (XC) integration grid, (2) profiling and optimization of the DFT code, and (3) TDDFT parallelization. We summarize the work performed in these task areas and present the resulting performance improvement. These software enhancements are available in 12JAN2009R3 or later versions of GAMESS. 相似文献
997.
998.
Udovydchenkov IA Brown MG Duda TF Mercer JA Andrew RK Worcester PF Dzieciuch MA Howe BM Colosi JA 《The Journal of the Acoustical Society of America》2012,131(6):4409-4427
The results of mode-processing measurements of broadband acoustic wavefields made in the fall of 2004 as part of the Long-Range Ocean Acoustic Propagation Experiment (LOAPEX) in the eastern North Pacific Ocean are reported here. Transient wavefields in the 50-90 Hz band that were recorded on a 1400-m long 40 element vertical array centered near the sound channel axis are analyzed. This array was designed to resolve low-order modes. The wavefields were excited by a ship-suspended source at seven ranges, between approximately 50 and 3200 km, from the receiving array. The range evolution of broadband modal arrival patterns corresponding to fixed mode numbers ("modal group arrivals") is analyzed with an emphasis on the second (variance) and third (skewness) moments. A theory of modal group time spreads is described, emphasizing complexities associated with energy scattering among low-order modes. The temporal structure of measured modal group arrivals is compared to theoretical predictions and numerical simulations. Theory, simulations, and observations generally agree. In cases where disagreement is observed, the reasons for the disagreement are discussed in terms of the underlying physical processes and data limitations. 相似文献
999.
M. Hyslop A. Wurl S.A. Brown B.D. Hall R. Monot 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2001,16(1):233-236
A beam of Pb clusters is produced with the inert gas aggregation method and probed by electron diffraction. Analysis of the
diffraction patterns indicates that average cluster size can vary between 3 and 7 nm, according to nucleation conditions.
The diffraction patterns from beams with larger average cluster size are very similar to patterns calculated from model decahedron
clusters, while those for smaller cluster size do not appear to have simple geometrical face-centred cubic, decahedral, or
icosahedral structure.
Received 30 November 2000 相似文献
1000.
This paper describes the development of a non-contact system for measuring colour of printed material at web speeds. The system proposed uses a non-contact spectrophotometer based on a holographic grating, in conjunction with a conventional monochrome area scan camera, from which colour spectral data is extracted, whilst a xenon flash is used to illuminate colour samples. Software and hardware details of the system are given, along with the underlying mathematics for colour space conversion and measurement. Conversion equations from X, Y, Z chromaticity co-ordinates to the RGB system are presented, and also equations to convert from the L*a*b* colour space to X, Y, Z chromaticity co-ordinates. Experimental results are presented whereby the non-contact spectral system is shown to perform to a colour tolerance exceeding that of conventional colour video systems. 相似文献