Synthesis and structure of new anionic five-coordinate silicon complexes derived from α-hydroxy acids and 1-methylpiperazine-2,5-dione

Russian Chemical Bulletin - Anionic five-coordinate complexes with two bis-O,O’-chelating ligands bearing α-hydroxy acid moieties, dicyclohexylammonium salts...     

Generation of an Attosecond Pulse in Helium Excited by Half-Cycle X-Ray Pulses

Optics and Spectroscopy - Conventionally, attosecond pulses are obtained using generation of high-order optical harmonics upon excitation of various media by femtosecond laser pulses with the...     

Population Gratings Created by a Pair of Unipolar Attosecond Pulses in a Three-Level Atomic Medium

Optics and Spectroscopy - The possibility of inducing population gratings in a three-level resonant medium using a pair of unipolar attosecond pulses that do not overlap in the medium has been...     

Extreme and Topological Nonlinear Optics of Open Systems

Optics and Spectroscopy - A review of results of an investigation of the theory of optical wave packets with extreme properties with respect to a controllable pulse shape or to the complexity of...     

Intravital Imaging Study on Photodamage Produced by Femtosecond Near‐infrared Laser Pulses In Vivo

Ultrashort femtosecond pulsed lasers may provide indispensable benefits for medical bioimaging and diagnosis, particularly for noninvasive biopsy. However, the ability of femtosecond laser irradiation to produce biodamage in the living body is still a concern. To solve this biosafety issue, results of theoretical estimations as well as the in vitro and in situ experiments on femtosecond biodamage should be verified by experimental studies conducted in vivo. Here, we analyzed photodamage produced by femtosecond (19, 42 and 100 fs) near‐infrared (NIR; ~800 nm) laser pulses with an average power of 5 and 15 mW in living undissected Drosophila larvae (in vivo). These experimental data on photodamage in vivo agree with the results of theoretical modeling of other groups. Femtosecond NIR laser pulses may affect the concentration of fluorescent biomolecules localized in mitochondria of the cells of living undissected Drosophila larva. Our findings confirm that the results of the mathematical models of femtosecond laser ionization process in living tissues may have a practical value for development of noninvasive biopsy based on the use of femtosecond pulses.     

Ferrocenylalkylation of 2-mercaptobenzoxazoles

Regioselectivity of the HBF₄-catalyzed ferrocenylalkylation of 2-mercaptobenzoxazole in two phase aqueous organic solvent mixture was studied. The reaction proceeds regioselectively at the heterocyclic nitrogen atom. Structures of the synthesized compounds were established by 2D NMR technique. Structure of 3-(1-ferrocenylbenzyl)benz[d]oxazol-2-thione was elucidated by X-ray diffraction.     

Assembly of lipids and proteins into lipoprotein particles

The self-assembly of reconstituted discoidal high-density lipoproteins, known as nanodiscs, was studied using coarse-grained molecular dynamics and small-angle X-ray scattering. In humans, high-density lipoprotein particles transport cholesterol in the blood and facilitate the removal of excess cholesterol from the body. Native high-density lipoprotein exhibits a wide variety of shapes and sizes, forming lipid-free/poor, nascent discoidal, and mature spherical particles. Little is known about how these lipoprotein particles assemble and transform from one state to another. Multiple 10 micros coarse-grained simulations reveal the assembly of discoidal high-density lipoprotein particles from disordered protein-lipid complexes. Small-angle X-ray scattering patterns were calculated from the final assembled structures and compared with experimental measurements carried out for this study to verify the accuracy of the coarse-grained simulations. Results show that hydrophobic interactions assemble, within several microseconds, the amphipathic helical proteins and lipids into roughly discoidal particles, while the proteins assume a final approximate double-belt configuration on a slower time scale.     

Measurement of the tensor analyzing power Ayy in the inelastic scattering of deuterons in the vicinity of excitation of baryonic resonances

The tensor A_yy and vector A_y analyzing powers in the inelastic scattering of deuterons with a momentum of 4.5 GeV/c on beryllium at an angle of 80 mr in the vicinity of baryonic resonances excitation have been measured. The A_yy data being in good agreement with the previous results obtained at a zero angle demonstrate an approximate t scaling up to - 0.9 (GeV/c)². The results of the experiment are compared with the predictions of the multiple-scattering and -meson exchange models. Received: 20 April 2000 / Accepted: 29 May 2000