"Click"-capture, ring-opening metathesis polymerization (ROMP), release: facile triazolation utilizing ROMP-derived oligomeric phosphates

Soluble, high-load ring-opening metathesis polymerization (ROMP)-derived oligomeric triazole phosphates (OTP) are reported for application as efficient triazolating reagents of nucleophilic species. Utilizing a "Click"-capture, ROMP, release protocol, the efficient and purification-free, direct triazolation of N-, O-, and S-nucleophilic species was successfully achieved. A variety of OTP derivatives were rapidly synthesized as free-flowing solids on a multigram scale from commercially available materials.     

Best proximity points: global optimal approximate solutions

Let A and B be non-empty subsets of a metric space. As a non-self mapping \({T:A\longrightarrow B}\) does not necessarily have a fixed point, it is of considerable interest to find an element x in A that is as close to Tx in B as possible. In other words, if the fixed point equation Tx = x has no exact solution, then it is contemplated to find an approximate solution x in A such that the error d(x, Tx) is minimum, where d is the distance function. Indeed, best proximity point theorems investigate the existence of such optimal approximate solutions, called best proximity points, to the fixed point equation Tx = x when there is no exact solution. As the distance between any element x in A and its image Tx in B is at least the distance between the sets A and B, a best proximity pair theorem achieves global minimum of d(x, Tx) by stipulating an approximate solution x of the fixed point equation Tx = x to satisfy the condition that d(x, Tx) = d(A, B). The purpose of this article is to establish best proximity point theorems for contractive non-self mappings, yielding global optimal approximate solutions of certain fixed point equations. Besides establishing the existence of best proximity points, iterative algorithms are also furnished to determine such optimal approximate solutions.     

Numerical and analytical solutions of an ODE: Strengths and weaknesses of the analytical series solution

The analytical solution for a nonlinear ordinary differential equation was obtained but was only applicable for lower input parameters. A numerical solution for the same equation which provided good results for all input parameters was also obtained. Since the analytical solution contained an infinite series, the solution depended on the number of terms used in the series, resulting in failure for certain input parameters at low time values.     

Phytochemical mediated gold nanoparticles and their PTP 1B inhibitory activity

Current discovery demonstrates the rapid formation of gold nanoparticles with guavanoic acid a phytochemical of Psidium guajava (Pg). The pharmacological capabilities of the phytochemicals present in the leaves of Pg and their ability to generate gold nanoparticles is presented herein. The new genre of green nanoparticles exhibit remarkable Protein Tyrosine Phosphatase 1B (PTP 1B) inhibitory activity and in vitro stability in various physiological medium including saline, histidine, cysteine, bovine serum albumin (BSA), human serum albumin (HSA) and buffers (pH 5, 7 and 9). It is predicted that this new technology will be felt greatly in several routes of pharmaceuticals.     

Transient analysis of a single server queue with catastrophes, failures and repairs

A transient solution is obtained analytically using continued fractions for the system size in an M/M/1 queueing system with catastrophes, server failures and non-zero repair time. The steady state probability of the system size is present. Some key performance measures, namely, throughput, loss probability and response time for the system under consideration are investigated. Further, reliability and availability of the system are analysed. Finally, numerical illustrations are used to discuss the system performance measures.      

Strategies towards the Synthesis of 6‐N,N‐Diethylcarbamyloxy‐1,4‐dimethoxy‐ 7‐naphthylboronic Acid

After acetylation, condensation between Danishefsky's diene and benzoquinone afforded a stable methoxytriacetoxydihydronaphthalene intermediate, which was subsequently transformed by the Snieckus DOM protocol into the regiospecific 7‐naphthylboronic acid.     

Proteomics Approach to Identify Unique Xylem Sap Proteins in Pierce’s Disease-Tolerant Vitis Species

Pierce’s disease (PD) is a destructive bacterial disease of grapes caused by Xylella fastidiosa which is xylem-confined. The tolerance level to this disease varies among Vitis species. Our research was aimed at identifying unique xylem sap proteins present in PD-tolerant Vitis species. The results showed wide variation in the xylem sap protein composition, where a set of polypeptides with pI between 4.5 and 4.7 and M _r of 31 kDa were present in abundant amount in muscadine (Vitis rotundifolia, PD-tolerant), in reduced levels in Florida hybrid bunch (Vitis spp., PD-tolerant) and absent in bunch grapes (Vitis vinifera, PD-susceptible). Liquid chromatography/mass spectrometry/mass spectrometry analysis of these proteins revealed their similarity to β-1, 3-glucanase, peroxidase, and a subunit of oxygen-evolving enhancer protein 1, which are known to play role in defense and oxygen generation. In addition, the amount of free amino acids and soluble sugars was found to be significantly lower in xylem sap of muscadine genotypes compared to V. vinifera genotypes, indicating that the higher nutritional value of bunch grape sap may be more suitable for Xylella growth. These data suggest that the presence of these unique proteins in xylem sap is vital for PD tolerance in muscadine and Florida hybrid bunch grapes.