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91.
In the synthesis of combinatorial chemical libraries on solid phase, there is a need to cleave the compounds from the solid
support before the library can be tested for biological activity. It is advantageous to use linkers which will release the
libraries by mild photolytic cleavage. We have developed six new linkers of the photosensitive α-methyl 2-nitrobenzyl type
containing amino, hydroxy, bromo and methylamino groups, and also 4-nitrophenoxycarbonyl activated OH and NH2 groups.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
92.
We present a general computational scheme based on molecular dynamics (MD) simulation for calculating the chemical potential of adsorbed molecules in thermal equilibrium on the surface of a material. The scheme is based on the calculation of the mean force in MD simulations in which the height of a chosen molecule above the surface is constrained and subsequent integration of the mean force to obtain the potential of mean force and hence the chemical potential. The scheme is valid at any coverage and temperature, so that in principle it allows the calculation of the chemical potential as a function of coverage and temperature. It avoids all statistical mechanical approximations, except for the use of classical statistical mechanics for the nuclei, and assumes nothing in advance about the adsorption sites. From the chemical potential, the absolute desorption rate of the molecules can be computed, provided that the equilibration rate on the surface is faster than the desorption rate. We apply the theory by ab initio MD simulation to the case of H2O on MgO (001) in the low-coverage limit, using the Perdew-Burke-Ernzerhof (PBE) form of exchange correlation. The calculations yield an ab initio value of the Polanyi-Wigner frequency prefactor, which is more than two orders of magnitude greater than the value of 10(13) s(-1) often assumed in the past. Provisional comparison with experiment suggests that the PBE adsorption energy may be too low, but the extension of the calculations to higher coverages is needed before firm conclusions can be drawn. The possibility of including quantum nuclear effects by using path-integral simulations is noted. 相似文献
93.
Studies on the antimicrobial properties of light have considerably increased due in part to the development of resistance to actual control methods. This study investigates the potential of light‐emitting diodes (LED) blue light for controlling Penicillium digitatum and Penicillium italicum. These fungi are the most devastating postharvest pathogens of citrus fruit and cause important losses due to contaminations and the development of resistant strains against fungicides. The effect of different periods and quantum fluxes, delaying light application on the growth and morphology of P. digitatum strains resistant and sensitive to fungicides, and P. italicum cultured at 20°C was examined. Results showed that blue light controls the growth of all strains and that its efficacy increases with the quantum flux. Spore germination was always avoided by exposing the cultures to high quantum flux (700 μmol m?2 s?1) for 18 h. Continuous light had an important impact on the fungus morphology and a fungicidal effect when applied at a lower quantum flux (120 μmol m?2 s?1) to a growing fungus. Sensitivity to light increased with mycelium age. Results show that blue light may be a tool for P. digitatum and P. italicum infection prevention during handling of citrus fruits. 相似文献
94.
Macarena G. Alférez Dr. Juan J. Moreno Nereida Hidalgo Dr. Jesús Campos 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(47):21049-21053
The use of cyclopentadienyl ligands in organometallic chemistry and catalysis is ubiquitous, mostly due to their robust spectator role. Nonetheless, increasing examples of non-innocent behaviour are being documented. Here, we provide evidence for reversible intramolecular C−H activation at one methyl terminus of C5Me5 in [(η-C5Me5)Rh(PMe3)2] to form a new Rh−H bond, a process so far restricted to early transition metals. Experimental evidence was acquired from bimetallic rhodium/gold structures in which the gold center binds either to the rhodium atom or to the activated Cp* ring. Reversibility of the C−H activation event regenerates the RhI and AuI monometallic precursors, whose cooperative reactivity towards polar E−H bonds (E=O, N), including the N−H bonds in ammonia, can be understood in terms of bimetallic frustration. 相似文献
95.
The bisphosphonates clodronate and alendronate are drugs in the therapy of osteoporosis or Paget's disease. They are highly hydrophilic and therefore of low oral bioavailability. Determination methods for bisphosphonates are often laborious and expensive equipment is needed. The presented quantification method based on kinetic measurement of the fluorescence decrease of an Al3+-morin complex can be used to determine the bisphosphonate content in aqueous and plasma samples. The intra- and inter-assay accuracies were found to be within 98.8% and 102.3% of the target samples for clodronate and within 97.2% and 105.0% of the target samples for alendronate. The LOQ was defined as 15.6 ng/ml for clodronate and 62.5 ng/ml for alendronate. In serum samples, intra- and inter-assay accuracy was found to be within 99.0% and 101.6% of the target samples for clodronate and within 97.8% and 102.6% of the target samples for alendronate. In serum samples, the LOQ was defined as 1.55 mg/ml for clodronate and 0.39 mg/ml for alendronate. Though less sensitive in serum, the presented method could support research on the development of drug delivery systems in vitro and in vivo for the investigated and other structurally related bisphosphonates. 相似文献
96.
97.
The effective and simple long-term storage of complex functional proteins is critical in achieving commercially viable biosensors. This issue is particularly challenging in recently proposed types of nanobiosensors, where molecular-motor-driven transportation substitutes microfluidics and forms the basis for novel detection schemes. Importantly, therefore, we here describe that delicate heavy meromyosin (HMM)-based nanodevices (HMM motor fragments adsorbed to silanized surfaces and actin bound to HMM) fully maintain their function when stored at -20 °C for more than a month. The mechanisms for the excellent preservation of acto-HMM motor function upon repeated freeze-thaw cycles are discussed. The results are important to the future commercial implementation of motor-based nanodevices and are of more general value to the long-term storage of any protein-based bionanodevice. 相似文献
98.
We present a detailed study of the energetics of water clusters (H(2)O)(n) with n ≤ 6, comparing diffusion Monte Carlo (DMC) and approximate density functional theory (DFT) with well converged coupled-cluster benchmarks. We use the many-body decomposition of the total energy to classify the errors of DMC and DFT into 1-body, 2-body and beyond-2-body components. Using both equilibrium cluster configurations and thermal ensembles of configurations, we find DMC to be uniformly much more accurate than DFT, partly because some of the approximate functionals give poor 1-body distortion energies. Even when these are corrected, DFT remains considerably less accurate than DMC. When both 1- and 2-body errors of DFT are corrected, some functionals compete in accuracy with DMC; however, other functionals remain worse, showing that they suffer from significant beyond-2-body errors. Combining the evidence presented here with the recently demonstrated high accuracy of DMC for ice structures, we suggest how DMC can now be used to provide benchmarks for larger clusters and for bulk liquid water. 相似文献
99.
Martin Sagmeister Bernhard Lamprecht Elke Kraker Stefan Köstler Volker Ribitsch Nicole Galler Harald Ditlbacher Joachim R. Krenn Birgit Ungerböck Tobias Abel Torsten Mayr 《Applied physics. B, Lasers and optics》2013,111(4):647-650
We demonstrate screen printing of polymer waveguides on rigid and flexible substrates. The waveguides are characterized by optical microscopy and propagation losses are determined by cut-back measurements. Furthermore, the efficiency of light coupling using fluorescent molecules within the waveguides is measured with regard to the application feasibility in sensor systems. It is shown that minimum propagation losses of 0.74 dB/cm can be reached with this low-cost printing technique. 相似文献
100.
Jan Fredrik Hansen Alf Kåre ådnanes Thor I. Fossen 《Mathematical and Computer Modelling of Dynamical Systems: Methods, Tools and Applications in Engineering and Related Sciences》2013,19(3):323-355
This article presents a mathematical model of a complete diesel-electric propulsion system, including components as diesel generators, distribution network, variable speed thruster-drives, and conventional motor loads. The model is split into two parts: One power generating part where the load is specified with an aggregated active and reactive power load demand. Secondly, a power consumption part where the effects of the different load types as thruster drives, motors and other loads are modelled. The model is written in a state-space form suitable for the purpose of simulation and control design. PID-controllers represent speed governors and automatic voltage regulators. 相似文献