Microwave Induced Synthesis of 3‐Aryl‐6‐(6‐/8‐substituted 4‐chloroquinoline‐3‐yl) ‐ s ‐triazolo [3,4‐b] −1,3,4‐thiadiazoles

The condensation of 4‐amino‐3‐aryl‐5‐mercapto‐1, 2, 4‐triazoles (1a‐f) with 6‐/8‐substituted 1,4‐dihydro‐4‐oxo‐quinoline‐3‐carboxylic adds (2a‐d) in the presence of phosphorus oxychloride on refluxng or under microwave irradiation gave twenty four novel 3‐aryl‐6‐ (6‐/8‐substituted 4‐chloroquinoline‐3‐yl)‐s‐triazolo[3,4‐b]‐1, 3,4‐thiadiazoles (4a‐x), Considerable increase in the reaction rate has been observed with improved yields under microwave irradiation. The structures of the compounds synthesized were determined by elemental analyses, IR, ¹H NMR and MS spectra. Their spectral properties and the reaction mechanism were also discussed. The preliminary biological test showed that some of compounds bad moderate antibacterial activities.     

Synthesis and Antibacterial Activity of 3‐(5‐Methylisoxazol‐3‐yl) −1,2,4‐triazolo [3,4‐b]‐1,3,4‐thiadiazine Derivatives

The condensed products 2‐10 of 4‐amino‐5‐mercapto‐3‐(5‐methylisoxazol‐3‐yl)‐l,2,4‐triazole (1) with chloroacetaldehyde, 2‐bromocyclohexanone, chloranil, ωbromo‐ω‐(1H‐1, 2,4‐triazol‐l‐yl)acetophenone, 2‐bromo‐4′‐substituted acetophenones and 2‐bromo‐6′‐methoxy‐2′‐acetonaphthone were described. The antibacterial activities were also evaluated.