Berberis alkaloids. XXIX. An investigation of the alkaloids ofBerberis sibirica

The alkaloid compositions of the roots, young shoots, and leaves of Berberis sibirica have been studied, and berberine, palmatine, columbamine, berberrubine, oxyacanthine, berbamine, 8-oxoberberine, 8-oxoberrberubine, pakistanine, and pronunciferine, and also the new base N-acetylhomoveratrylamine have been isolated. This is the first time that any of these alkaloids, except berberine, have been isolated from this plant.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances of the Academy of Sciences of the Uzbekistan Republic, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 424–428, May–June, 1993.     

Berberis alkaloids. XXIII. Structure of turcberine

Berberine, magnoflorine, palmatine, columbamine, jatrorhizine, epiberberine, berbamine, O-methylisothalicberine, armepavine, corypalline, glaucine, and corydine and the new alkaloid turcberine have been isolated fromBerberis turcomanica Kar., and the structure of turcberine has been established. Apart from berberine, this is the first time that any of these alkaloids have been isolated from this species of barberry, while this is the first time that corydine and armepavine have been isolated from the genusBerberis.Institute of Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences. Tashkent. Andizhan State Medical Institute. Translated from Khimiya Prirodnykh Soedeninii, No. 1, pp. 77–81, January–February, 1993.     

Berberis alkaloids. The new alkaloid oblongamine

Summary 1. The alkaloid compositions of young shoots ofBerberis integerrima andB. oblonga have been studied. Berbamunine, hydroxyacanthine, magnoflorine, berberine, and palmatine have been isolated.2. The new monoquaternary bisbenzylisoquinoline alkaloid oblongamine has been isolated from the roots ofB. oblonga.3. The most probable structure of oblongamine has been suggested on the basis of chemical reactions and spectral characteristics.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. M. I. Kalinin Andizhan State Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 80–83, January–February, 1977.     

New alkaloids fromHaplophyllum

The new alkaloid foliphorin is isolated fromHaplophyllum foliosum (Rutaceae). Spectral data establish the structure as 1-methyl-4-methoxy-8(2′-O-acetyl-3′-hydroxy-3′-methylbutyloxy)-2-quinolone. Dihydrohaplamine, which is observed for the first time in nature, is obtained fromHaplophyllum perforatum. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (371) 120 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 634–636, September–October, 1999.     

Berberis alkaloids XXXIX. New alkaloids fromB. densiflora

The alkaloid composition of the leaves ofBerberis densiflora has been studied. Berberine, -allocryptopine. oxyacanthine, glaucine, thalicmidine, isocorydine, O-methylcorypalline and the new bases densinine and densiberine have been isolated. The structures of the new alkaloids have been established by a study of spectral characteristics and chemical transformations. This is the first time that any of the known alkaloids, apart from berberine, have been isolated from a plant of this pecies and it is the first time that -allocryptopine and O-methylcorypalline have been isolated from theBerberis genus.     

Berberis alkaloids XIV. Dynamics of the accumulation of alkaloids in Berberis oblonga

Andizhan State Medical Institute. Institute of Chemistry of Plant Substances, Uzbekistan Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 597–598, September–October, 1992.     

Structure of the alkaloids of Aerva lanata

By the NOE method using¹³C NMR and UV spectra we have confirmed the structures of four new alkaloids isolated previously: 10-hydroxycanthin-6-one (ervine), 10-methoxycanthine-6-one (methylervine), 10-β-D-glucopyranosyloxycanthin-6-one (ervoside), and 6-methoxy-β-carbolin-l-ylpropionic acid (ervolanine). All-Union Scientific-Research Institute of Drugs Scientific-Production Association, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 821–824, November–December, 1991.     

Berberis alkaloids. XVII. Investigation of the alkaloids of Berberis heteropoda

The alkaloid composition of young shoots and leaves ofBerberis heteropoda Schrenk has been studied. In addition to known alkaloids, two new ones have been isolated — N-methyldihydroberberine and 8-oxoberberrubine, the structures of which were established by chemical transformations and a study of spectral properties. Of known alkaloids, berbamunine, aromoline, glaucine, thalicmidine, isocorydine, and reticuline have been found in this plant for the first time. Pseudopalmitine and laudanosine have been found for the first time in plants of the genusBerberis.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances of Uzbek Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 53–59, January–February, 1993.     

Synthetic analogs of Peganum alkaloids VI. Photochemical oxidation of 2,3-polymethylene-quinazoline derivatives

The rates of the photochemical oxidation of quinazoline alkaloids — deoxypeganine, peganine, pentamethylenequinazoline, and peganol — to the corresponding oxo derivatives have been studied. It has been shown by HPLC that the oxidation of deoxypeganine proceeds through a stage of the formation of a carbinolamine (peganol); in the case of its hydrochloride, the reaction takes place by the same scheme but four times more slowly. Tetra- and pentamethylenequinazolines have been synthesized and information on their melting points in the literature has been corrected. In the series trimethylenequinazoline-pentamethyl-enequinazoline-tetramethylenequinazoline the stability falls from left to right. Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 528–532, July–August, 1991.     

Reactions of lycoctonine alkaloids containing a 7,8-methylenedioxy group with Na in liquid ammonia

The reactions of 6-dehydroeldelidine and 6-dehydrodelcorine with sodium in liquid ammonia have been studied. Structures have been put forward for the compounds obtained. Features of the fragmentation of these compounds under electron impact are discussed. Abu Ali Ibn Sina [Avicenna] Tadzhik State Medical Institute, Dushanbe. Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 527–532, July–August, 1989.     

Synthetic analogues of Peganum alkaloids. V. Peganol from deoxpeganine

Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 857–858, November–December, 1989.     

Secondary metabolites of Pyricularia oryzae II. Polyketide metabolites

A number of exometabolites have been isolated from the deuteromycetePyricularia oryzae Cav., of which harman and O-demethyldiaporthin have been isolated from this species for the first time. The latter is the first example of a hexaketide from fungi of the genusPyricularia, for which only penta- and heptaketides have previously been described. All-Union Scientific-Research Institute of Phytopathology, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 471–475, July–August, 1991.     

Alkaloids ofPetilium eduardi. Petine and petine N-oxide

Two new alkaloids — petine and petine N-oxide — have been isolated from the bulbs of Petilium eduardi. Their structures have been established on the basis of spectral characteristics and chemical transformations. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, FAX (3712) 89-14-75. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 524–528, July–August, 1994.     

NMR investigation of alkaloids. XI.13C NMR spectra and structure of codonopsine and codonopsinine

An assignment of the signals in the¹³C NMR spectra of the alkaloids codonopsinine and codonopsine has been made on the basis of selective double heteronuclear resonance experiments. Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 536–538, July–August, 1989.     

Alkaloids ofNitraria komarovii XVII. Peganine N-oxide,N-allylschoberine,and dehydronitramidine

Three new alkaloids have been isolated from the epigeal part ofNitraria komarovii — peganine N-oxide, N-allylschoberine, and dehydronitramidine. Their structures have been determined on the basis of chemical transformations and spectral results. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 780–783, November–December, 1994.     

Polysaccharides ofUngernia. XV. A study of the pectin substances of the leaves ofUngernia tadschicorum

Pectin substances have been isolated from the leaves ofUngernia tadschicorum and characterized. A galacturonan has been obtained by partial hydrolysis. On the basis of the results of IR spectroscopy and periodiate — nitric acid oxidation, its structure has been established as an α-1→4-bound polymer-homolog. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, FAX (3712) 62 73 48. Translated from Khimiya Prirodnykh Soedinenii, No. 3, 320–322, May–June, 1994.     

Methods of isolating alkaloids of the colchicine series

This review considers methods for the isolation of colchicine, colchamine, and colchicoside. The literature for the period from 1884 to 1997 has been used. I. G. Kutateladze Institute of Pharmacochemistry, Academy of Sciences of the Georgian SSR, Tbilisi. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 592–600, September–October, 1990.     

Berberis alkaloids. XVI. Structure of berpodine

The alkaloid composition of young shoots ofBerberis heteropoda has been studied. Together with known alkaloids, we have isolated the new dimeric base berpodine and have established its structure by a study of spectral characteristics and by chemical transformations. The known alkaloid isotetrandrine has also been isolated from this plant, for the first time.Institute of Chemistry of Plant Substances Uzbekistan Republic Academy of Sciences, Tashkent. Andizhan State Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 264–267, March–April, 1993.     

Natural antioxidants. Furanoeremophilanes from Cacalia roots

Sesquiterpene compounds of the furanoeremophilane series have been isolated from extracts of the roots ofCacalia sp. growing in the Soviet Far East. The presence of antioxidant and antiradical activities in two representatives of the series has been established. Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Branch, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 643–646, September–October, 1989.     

Spectroscopy of maize proteins II. Albumins

The albumins of maize grain isolated by precipitation from a total salt extract have been investigated by IR, UV, derivative, and fluorescence spectroscopy. It has been shown that the variability of the spectral parameters is connected with a change in the association of the proteins with nonprotein substances according to the genotype of the maize. Scientific-Research Institute of Biology, Dnepropetrovsk State University. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 549–553, July–August, 1991.