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1.
D. V. Moiseev N. V. Demidova V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2006,42(1):60-63
A method has been developed for the one pot synthesis of 1′-alkyl-1′,4′-dihydro-2.3′-biquinolyl-4′-thiones based on the reduction
of 1-alkyl-3-(2-quinolyl)quinolinium halides with sodium borohydride and subsequent thiolation. 1′-Alkyl-1′,4′-dihydro-2,3′-biquinolyl-4′-ones
were obtained in close to quantitative yield by the oxidation of 1′-alkyl-1′, 4′-dihydro-2,3′-biquinolyl-4′-thiones.
For Part 17 see [1].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 67–70, January, 2006. 相似文献
2.
N. V. Demidova N. Ts. Karaivanov V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2005,41(9):1167-1172
A method has been developed for the synthesis of bromo and chloro derivatives of 2,3′-biquinoline and 2,3′-biquinolones based
on the bromination and chlorination in various media. It was found that the bromination of 2,3′-biquinoline in strongly acidic
medium occurred on the 2-quinoline fragment and in weak acid on the 3-quinoline and that it takes place via a stage of formation
of a dihydro derivative. 1′-Alkyl-1′, 4′-dihydro-2,3′-biquinolin-4′-ones and 1′-alkyl-1′,2′-dihydro-2,3′-biquinolin-2′-ones
are halogenated at position 6′.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1372–1377, September, 2005. 相似文献
3.
D. V. Moiseev V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2006,42(10):1308-1310
A method has been developed for the synthesis of 2′-and 4′-aryl-2,3′-biquinolyls based on the reaction of 1′-alkyl-2′-aryl-1′,2′-dihydro-2,3′-biquinolyls
and 1′-alkyl-4′-aryl-1′,4′-dihydro-2,3′-biquinolyls with sulfur in DMF.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1517–1519, October, 2006. 相似文献
4.
A. V. Aksenov A. V. Sarapii O. A. Antonova I. V. Borovlev V. I. Goncharov 《Chemistry of Heterocyclic Compounds》2005,41(8):1031-1035
The reaction of 1-alkyl-3-(2-quinolyl)quinolinium iodides with excess zinc in THF gives a diastereomeric mixture of 1,1′-dialkyl-3,3′-di(2-quinolyl)-1,1′,4,4′-tetrahydro-4,4′-biquinolyls.
An excess of lithium in THF gives a mixture of 1′,2′-dihydro-2,3′-biquinolyl and 1′-alkyl-1′, 4′-dihydro-2,3′-biquinolyl with
the former predominating. The reduction by lithium in THF of 1,1′-dialkyl-3,3′-di(2-quinolyl)-1,1′,4,4′-tetrahydro-4,4′-biquinolyls
leads to analogous products. Reduction of 1-alkyl-3-(2-quinolyl)quinolinium iodides by metallic potassium gives 1-alkyl-1′,4′-dihydro-2,3′-biquinolyls.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1208–1212, August, 2005. 相似文献
5.
Vytautas Getautis Albina Stanisauskaite Rimgaile Degutyte Jolanta Stumbraite 《Monatshefte für Chemie / Chemical Monthly》2007,138(12):1293-1296
Summary. Intramolecular cyclization of N,N′-di(3-chloro-2-hydroxy)propyl-N,N′-diphenylbenzidine occurs to give bis-1,2,3,4-tetrahydroquinoline derivative 1,1′-diphenyl-1,2,3,4,1′,2′,3′,4′-octahydro-6,6′-biquinolinyl-3,3′-diol. 相似文献
6.
O. A. Antonova V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2006,42(2):197-199
1,1′-Dialkyl-3,3′-di(2-quinolyl)-1,1′,4,4′-tetrahydro-4,4′-biquinolines react with organolithium and organo-magnesium compounds
to form 1′-alkyl-2′-R-1′,2′-dihydro-2,3′-biquinolines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, 224–226, February, 2006. 相似文献
7.
Yu. S. Kosenkova M. P. Polovinka N. I. Komarova D. V. Korchagina S. V. Morozov A. I. Vyalkov N. Yu. Kurochkina V. A. Cheremushkina N. F. Salakhutdinov 《Chemistry of Natural Compounds》2008,44(5):564-568
Flavones 2′,5′-dimethoxyflavone, 3′-methoxy-4′,5′-methylenedioxyflavone, 3′,4′-dimethoxyflavone, 5,6,2′,3′,6′-pentamethoxyflavone,
and 5,6,2′,3′,5′,6′-hexamethoxyflavone; salicylates, methyl-4-methoxysalicylate and peonol; and bisbibenzyl polyphenol riccardin
C were isolated for the first time from the acetone extract of the aerial part of Primula macrocalyx Bge. The content of free and total fatty acids was determined by GC and GC—MS. Palmitic (16:0), octadecatetraenoic 18:4 (6,9,12,15),
linoleic 18:2 (9,12), and α-linolenic 18:3 (9,12,15) were the principal acids from the aerial part of Primula macrocalyx.
Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 457–460, September-October, 2008. 相似文献
8.
T. P. Glushenko V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2008,44(3):314-315
A method has been developed for the synthesis of 1′-R-1′,4′-dihydro-2,3′-biquinolin-4′-ones based on the interaction of quinaldine
with N-alkyl-N-formylanthranilic acid methyl esters under the conditions of the Claisen condensation.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 409–410, March 2008. 相似文献
9.
Katarzyna Michalik Zofia Drzazga Anna Michnik 《Journal of Thermal Analysis and Calorimetry》2008,93(2):521-526
A study of 2′,3′-dideoxyinosine (ddI) stability and its interaction with human serum albumin (HSA) was carried out by differential
scanning microcalorimetry DSC. Scan rate dependent and irreversible endothermic thermal degradation of ddI was analyzed with
use of kinetic approach. Observed process could be interpreted in terms of simple first-order one step kinetic model. Moreover
it was shown that ddI bound weakly to the human serum albumin and stabilized this protein. 相似文献
10.
First indirect evidence for the formation of a radical cation of 1,8-bis(dimethylamino)naphthalene (“proton sponge”) in reactions
with HNO3, HNO2, NO2, and I2 has been obtained. In all cases, the products of reaction of the radical cation with nucleophiles and/or its dimer, 4,5,4′,5′-tetrakis(dimethylamino)-1,1′-binaphthyl,
have been isolated. 4-Chloro-1,8-bis(dimethylamino)naphthalene has been regioselectively synthesized in high yield.
For Part 24, see Ref. 1.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 320–324, February, 1998. 相似文献
11.
E. V. Zhernosek S. V. Kvach L. A. Eroshevskaya E. N. Kalinichenko A. I. Zinchenko 《Chemistry of Natural Compounds》2006,42(2):208-211
Previously undescribed conjugates of 2′,3′-dideoxyuridine-5′-monophosphate-(L)-methoxytryptophylphosphoramidate (5) and 2′,3′-dideoxycytidine-5′-monophosphate-(L)-methoxytryptophylphosphoramidate (7) were isolated by a chemical enzymatic method in order to study their pharmacological properties and to prepare new medicinal
preparations based on them.
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 173–175, March–April, 2006. 相似文献
12.
Synthesis, structures, and properties of spiro[6-azaperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one derivatives 总被引:1,自引:0,他引:1
V. N. Komissarov E. N. Gruzdeva L. P. Olekhnovich G. S. Borodkin V. N. Khrustalev S. V. Lindeman Yu. T. Struchkov V. A. Kogan V. I. Minkin 《Russian Chemical Bulletin》1997,46(11):1924-1930
The reaction of 5-amino-4-chloroquinolines with 4-amino-2,6-di-tert-butylphenol yielded derivatives of spiro[6-azaperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one, which exhibit photo-and thermochromic
properties in solutions. The structure of 2′,6′-di-tert-butyl-5,7,9-trimethylspiro[6-aza,-2,3-dihydroperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one was established by X-ray diffraction
study. The ring-chain isomerization of 2′,6′-di-tert-butyl-5,7-dimethyl-and 2′,6′-di-tert-butyl-5,7,8-trimethylspiro[6-aza-2,3-dihydroperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-ones was studied by dynamic NMR spectroscopy.
Deceased.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2028–2034, November, 1997. 相似文献
13.
Quenching kinetics of the 4,4′-dimethylbenzophenone triplet state with para-substituted phenol derivatives RC6H4OH (R = H, F, Cl, Br, I) was studied by nanosecond laser photolysis in aqueous micellar solutions of sodium dodecyl sulfate.
The kinetic data were processed in the framework of a model with the Poisson distribution of phenols between micelles. The
partition constants of RC6H4OH between the aqueous and micellar phases and the rate constants of their escape from a micelle and quenching of the 4,4′-dimethylbenzophenone
triplet state with phenols in micelles were obtained. The quenching proceeds with high rate constants through hydrogen atom
transfer to form the ketyl and phenoxyl radicals (no radicals are formed in the case of 4-iodophenol), which then recombine
in a micelle or escape into the outer aqueous volume. The application of an external magnetic field retards radical pair recombination
in a micelle and increases the fraction of radicals escaped into the aqueous phase. The quantum yield of radical pairs decreases
2.5-fold, and the rate of their recombination in micelles increases 2.5-fold on going from 4-chloro- to 4-bromophenol. This
is caused by the acceleration of triplet radical pair recombination in the solvent cage.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1391–1396, June, 2005. 相似文献
14.
Ge Zhang Mei-Li Guo Run-Ping Li Ying Li Han-Ming Zhang Zhong-Wu Su 《Chemistry of Natural Compounds》2009,45(3):398-401
A novel compound, 4-{1′-hydroxy-1′-mercapto-1′-[1′′-2′′(N→O)-isoquinolyl]}yl-1-benzoic acid (1), together with six known compounds, 6-hydroxykaempferol-3-O-β-D-glucopyranoside (2), rutin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), cartormin (6), hydroxysafflor yellow A (7), were isolated by chromatography from the n-BuOH fraction of 50% ethanol extraction of Flos carthami. Their structures were
elucidated on the basis of spectral analysis and comparison with published data. Among them, compound 1 was shown to possess a weak protective effect against cerebral ischemic damage in rats.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 339–341, May–June, 2009. 相似文献
15.
We have developed a method of synthesis of benzo[5,6]indolizino[2,1-b]quinolinium-13-thiolates and 5,6-dihydrobenzo[5,6]indolizino[1,2-c]quinoline-6-thiones
based on the reaction of the corresponding 1′, 2′-dialkyl-1′,2′-dihydro-2,3′-biquinolines and 1′,4′-dialkyl-1′,4′-dihydro-2,3′-biquinolines
with sulfur in DMF.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 849–851, June, 2007. 相似文献
16.
Hyun-Jung Lee Oh-Kyu Lee Yeong-Han Kwon Don-Ha Choi Ha-Young Kang Hyeon-Yong Lee Ki-Hyon Paik Hak-Ju Lee 《Chemistry of Natural Compounds》2006,42(4):415-418
Four known isoflavone glucosides have been isolated from the bark of Amorpha fruticosa, which is a traditional remedy plant,
for the first time. They were elucidated as 3′-hydroxy-4′-methoxyisoflavone-7-O-β-D-glucopyranoside (1), 4′,6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (2), 4′-methoxyisoflavone-7-O-β-D-glucopyranoside (3), and 3′,5-dihydroxy-4′-methoxyisoflavone-7-O-β-D-glucopyranoside (4), based on the UV, FT-IR, EIMS, FABMS, HREIMS, and NMR (1H and 13C, DEPT, COSY, NOESY, HMQC, and HMBC) data.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 336–338, July–August, 2006. 相似文献
17.
T. P. Glushenko V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2008,44(8):973-978
Methods have been developed for the synthesis of 2,3′-biquinolines, their 1′,4′-dihydro derivatives, 3-pyrid-2-ylquinolines,
and 3-pyrazin-2-ylquinoline based on the interaction of hetarylethylenes and vinyl butyl ether with imidoyl chlorides and
Vilsmeier complexes. Using the example of the synthesis of 3-hetarylquinolines and their dihydro derivatives the synthetic
possibilities of the Vilsmeier method were shown for creating various bonds in different quinoline nuclei of the bisheterocyclic
system.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1209–1215, August, 2008. 相似文献
18.
Platinum-based antitumour drug ZD0473 was designed to reduce the cisplatin resistance to the tumor cells. In this paper, the mixed method of molecular mechanics and quantum chemistry, HF/lanl2dz// MM/uff and B3LYP/lanl2dz//6-31G*, are used to investigate the differences between four types of GG, 3′AG5′, 3′GA5′, and AA complexes, which are formed from four discrete DNA fragments recognized by ZD0473 and cisplatin. The results show that the binding interaction of both ZD0473 and cisplatin drugs with the GG base pair is much stronger than with other base pairs, namely the recognition capability of such drugs to the GG base pair is more considerable. Moreover, the interaction of four complexes of ZD0473 with DNA fragments is stronger than that of cisplatin with corresponding DNA fragments, which indicates the stronger binding capability of ZD0473 with DNA fragments and high antitumour activity of ZD0473. The main reason for easier forming of 3′GA5′ complex than the 3′AG5′ one is that the drug molecule prefers to bind with a single G base to form a monoligand compound firstly; then the con- figuration transformation from such monoligand compound to the bi-ligand one is limited. 相似文献
19.
The application of near-infrared (NIR) dyes (λ
em > 750 nm) to the analysis of biological samples shows much promise, because the long emission wavelengths of such dyes allow
interferences from biomolecule matrices to be minimized. In this paper, a novel NIR dye, 5,5′-dicarboxy-1,1′-disulfobutyl-3,3,3′,3′-tetramethylindotricarbocyanine
(DCDSTCY) has been developed for the spectrophotometric determination of total protein in serum. Under acidic conditions,
the binding of DCDSTCY to proteins caused a new peak at 878 nm, the height of which was proportional to the concentration
of protein. The linear range of the method was found to be 0.04–0.5 μg mL−1 for bovine serum albumin (BSA) and human serum albumin (HSA), and detection limits of 5 ng mL−1 were obtained for these substances. The maximum binding number of BSA with DCDSTCY was measured to be 133. The method proposed
here has been applied to the quantitation of total protein in serum, and recoveries of 96.6–104% were achieved.
Figure Near-infrared probe for protein determination 相似文献
20.
A method has been developed for the synthesis of 2,2′- and 3,3′-biquinolines and of 4,4′-bipyridine based on the coupling
of 2- and 3-bromoquinoline or 4-bromopyridine using a Pd/C-hydrazine-KOH catalytic system.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1839–1840, December, 2008. 相似文献