JOURNAL OF NATURAL GAS CHEMISTRY AUTHOR INDEX OF VOLUME 15

A G Abdullah，Zalizawati，247 Ah6n，Vfotor R.，307 Alavi，S.M.，327 Amin，Nor Aishah Saidina 191，259，340 Ammasi，Sriraj，191 An，G的jun，127 Anggoro，Didi Dwi，340 Ge，Zhonghua，164 Gu，Y.，73 Guo，Bo，223 Guo，Jianjun，52 Guo，Xiaohui，105 H B Bai，Liang，105 Bakar，W.Azelee W.Abu，259 Bao，Xinhe，181 Batuev，Lubsan，149 Burgina，Elena，149 Ha￡axlioglu，P.，73 Han，Huajun，303 Hong，Kong Bee，266 Hu，Xiaofang，58 Hu，Xi加jun，100 Huang，Shengjun，93 Huang，Xingyun，3…     

用ICP研究鹿科动物骨质疏松症的微量元素特征

鹿科动物的骨质疏松症是近几年出现的一种疾病，它影响鹿的生长发育和繁殖，病重者死亡。我们采集梅花鹿和白唇鹿的毛，血样，用低温灰化方法和温法消解处理样品，用ＩＣＰ分析了毛，血清中微量元素的含量。病梅花鹿毛样中Ｍｇ，Ａｌ，Ｃａ，Ｔｉ，Ｆｅ，Ｃｕ，Ｚｎ的含量比正常组高，Ｔｉ，Ｃｕ，Ｚｎ的偏差率大于１５％，而Ｓｉ，Ｍｎ，Ｐ，Ｐ，Ａｇ，Ｂａ，Ｌａ，Ｃｅ，Ｐｂ比正常组低，Ｖ，Ａｇ，Ｂａ，Ｌａ，Ｃｅ，Ｐｂ存在...     

环酮的构象研究进展

综述了30多年来环酮（n=8，9，10，11，12，13，14，15，16）及对称的偶数 环二酮（n=8，10，12，14，16，18，20，22，24，26）的构象研究进展。     

《功能高分子材料》

全书共分17章，结合功能高分子材料的结构与性能、制备方法及应用领域，对离子交换树脂，吸附树脂，离子交换纤维和活性碳纤维，高分子膜分离材料，高分子色谱固定相，高分子试剂，高分子负载催化剂，导电高分子材料，电效发光聚合物材料，非线性光学高分子材料，液晶高分子材料，感光高分子材料，医用高分子材料，环境敏感高分子材料，高分子电解质，高分子染料，淀粉，纤维素衍生物高分子等进行了详细论述。[第一段]     

梅州农村饮用水重金属元素监测与分析

对梅州农村饮用水中的重金属元素进行了监测和分析，选择Fe，Mn，Zn，Cu，Ag，Pb，Cd七种元素为检测指标。从实验结果来看，Cu，Ag，Cd含量低，未超标；Fe，Mn，Zn，Pb有超标现象：按其危害程度，Pb，Mn的超标是急需解决的问题。     

压电液相化学分析

压电液相分析方法有吸附，电解沉积，频移滴定，化学频移，萃取频移，介电分析，内电解，选择性络合，催化，催化，化学倍增，氧瓶燃烧测频，多元混合物速测等法，可用于无机物，有机物，药物，环境，冶金，食品和饮料等分析。     

Author Index Vol. 25 No. 1-6, 2007

AUthor Index甘。!.25目0.卜‘.2007 Li，Hua Li，Ji Li，J ian一ling Li，Ji一Peng Li，Kai一un Li，Meng一yan Li，Shi一ben Li，Shi一yun Li，Shu一ning Li，51一dong Li，X iao一yu Li，Yan一guo Li，Yue一sheng Li，Ting Liang，Dong Liang，51 Ling，Fang Liu，Bin Liu，Jing Liu，Jing一yu Liu，Lan Liu，Qun一feng Liu，Zong一tang L6tzseh，D. Lu，Man一geng Lu，Yl Luo，Hong一xin Luo，Jing Luo，Yuan一fang Luo，Zheng一hong Lv，Rui 331 181 3 11 227 651 331 525 1 87 555 635 2 17 325 325 207 59…     

综合治疗脑梗塞68例观察

脑梗塞是常见病，且大部分可引起偏瘫，失语，智能障碍等后遗症，严重影响病人的生存质量，广州市第六人民医院于１９９５年１月～１９９７年６月采用中西药物，传统治疗，功能障碍治疗，心理治疗，氦氖激光血管内照射，血液光量子疗法，高压氧等综合治疗脑梗塞６８例，总疗程３个月，结果，总有效率９４．１％，显效率６４．１％，明显高于单用药物治疗的显效率，说明综合治疗可提高疗效，减少后遗症及致残率，且病程越短，疗效越好     

1，2，4－三嗪类化合物的研究（ⅩⅫ）──咪唑并－（5，4－e）－1，2，4－三嗪衍生物的合成

１，２，４－三嗪类化合物的研究（ⅩⅫ）──咪唑并－（５，４－ｅ）－１，２，４－三嗪衍生物的合成沙耀武，蔡孟深（北京医科大学药学院，北京，１０００８３）关键词乙二脒腙，原甲酸三乙酯，１，２，４－三嗪，咪唑并－（５，４－ｅ）－１，２，４－三嗪天然碱基拮抗...     

广州老人钙及磷,铁,锌,硒营养状况的研究

通过称量法，记帐法和询问法对广州市三所老人院１８０名老人进行了营养调查，并分析了钙，磷，铁，锌，硒的营养状况，结果表明，每人每日营养元素摄入量为钙４０３ｍｇ，磷８０７ｍｇ，铁１７ｍｇ，锌１４ｍｇ硒４６μｇ据此认为，广州老人缺钙，锌，硒。原因是饮食习惯不良，主食钙，锌，硒量低及食谱不合理，建议对老人改革主食结构，进食营养平衡米，制定合理的食谱，增加户外活动，多晒太阳，进行钙，锌，硒补充。     

透明材料的表面改性与防雾防霜性

介绍了透明材料表面防雾防霜的几种基本原理及其具体实施办法。综述国内外以防雾防霜为目的的表面改性的研究及其进展。尤其针对透明树脂表面改性 ,作了深入的讨论 ,并提出了自己的解决办法。     

Synthesis of stereopentad analogues of the C14-C22 segment of callystatin A through additions of chiral allenylzinc reagents to stereotriads.

The addition of (P)- and (M)-allenylzinc reagents, prepared in situ through Pd-catalyzed metalation of (R)- and (S)-3-butyn-2-ol mesylates, to diastereomeric stereotriad aldehydes 8, 13, 18, and 23 of syn,syn, syn,anti, anti,anti, and anti,syn stereochemistry was examined. Additions to the former two aldehydes afforded the four anti adducts with high diastereoselectivity and negligible mismatching. Significant mismatching was observed with the latter two aldehydes and the (M)-allenylzinc reagent. An evaluation of possible transition states is presented in consideration of steric and dipolar control elements.     

Molecularly Engineered Macrophage‐Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

Atherosclerosis (AS) is a major contributor to cardiovascular diseases worldwide, and alleviating inflammation is a promising strategy for AS treatment. Here, we report molecularly engineered M2 macrophage‐derived exosomes (M2 Exo) with inflammation‐tropism and anti‐inflammatory capabilities for AS imaging and therapy. M2 Exo are derived from M2 macrophages and further electroporated with FDA‐approved hexyl 5‐aminolevulinate hydrochloride (HAL). After systematic administration, the engineered M2 Exo exhibit excellent inflammation‐tropism and anti‐inflammation effects via the surface‐bonded chemokine receptors and the anti‐inflammatory cytokines released from the anti‐inflammatory M2 macrophages. Moreover, the encapsulated HAL can undergo intrinsic biosynthesis and metabolism of heme to generate anti‐inflammatory carbon monoxide and bilirubin, which further enhance the anti‐inflammation effects and finally alleviate AS. Meanwhile, the intermediate protoporphyrin IX (PpIX) of the heme biosynthesis pathway permits the fluorescence imaging and tracking of AS.     

Insulin Surface Acoustic Wave Immunosensor Based on Immobilized C60/Anti‐Insulin Antibody

Immobilized fullerene C₆₀/anti‐insulin antibody was prepared and applied in shear horizontal surface acoustic wave (SH‐SAW) immunosensors to detect insulin in aqueous solutions. The immobilizations of anti‐insulin onto fullerene were studied through a C₆₀/PVC coated SH‐SAW sensor system in liquid. The partially irreversible frequency response for an anti‐insulin antibody was observed by the desorption study, which implied that fullerene could chemically react with anti‐insulin. C₆₀/anti‐insulin coating materials were successfully prepared and identified with an FTIR spectrometer. The C₆₀/anti‐insulin coated SH‐SAW immunosensors were developed and applied for detection of insulin in aqueous solutions. Within the range of normal human insulin concentration, the SH‐SAW immunosensors immobilized with C₆₀/anti‐insulin exhibited linear frequency responses to the concentration of insulin with a sensitivity of 130 Hz/pM. The SH‐SAW immunosensor immobilized with C₆₀/anti‐insulin showed a detection limit of 0.58 pM for insulin in aqueous solution. The interference of various common bio‐species in human blood, e.g. urea, ascorbic acid, tyrosine, and metal ions, to the SH‐SAW immunosensor immobilized with C₆₀/anti‐insulin for insulin was investigated. These common bio‐species interferences showed nearly no interference to the SAW immunosensors coated with C₆₀/anti‐insulin. The reproducibility of the SH‐SAW immunosensor immobilized with C₆₀/anti‐insulin for insulin was also investigated and is discussed.     

Oriented immobilized anti‐hIgG via Fc fragment‐imprinted PHEMA cryogel for IgG purification

Antibodies are used in many applications, especially as diagnostic and therapeutic agents. Among the various techniques used for the purification of antibodies, immunoaffinity chromatography is by far the most common. For this purpose, oriented immobilization of antibodies is an important step for the efficiency of purification step. In this study, F_c fragment‐imprinted poly(hydroxyethyl methacrylate) cryogel (MIP) was prepared for the oriented immobilization of anti‐hIgG for IgG purification from human plasma. Non‐imprinted poly(hydroxyethyl methacrylate) cryogel (NIP) was also prepared for random immobilization of anti‐hIgG to compare the adsorption capacities of oriented (MIP/anti‐hIgG) and random (NIP/anti‐hIgG) cryogel columns. The amount of immobilized anti‐hIgG was 19.8 mg/g for the NIP column and 23.7 mg/g for the MIP column. Although the amount of immobilized anti‐hIgG was almost the same for the NIP and MIP columns, IgG adsorption capacity was found to be three times higher than the NIP/anti‐hIgG column (29.7 mg/g) for the MIP/anti‐hIgG column (86.9 mg/g). Higher IgG adsorption capacity was observed from human plasma (up to 106.4 mg/g) with the MIP/anti‐hIgG cryogel column. Adsorbed IgG was eluted using 1.0 m NaCl with a purity of 96.7%. The results obtained here are very encouraging and showed the usability of MIP/anti‐hIgG cryogel prepared via imprinting of Fc fragments as an alternative to conventional immunoaffinity techniques for IgG purification. Copyright © 2012 John Wiley & Sons, Ltd.     

Two New 4‐Hydroxyisoflavanes from the Root of Codonopsis cordifolioidea and Their Anti‐virus Activities

Two new 4‐hydroxyisoflavanes, cordifoliflavanes A and B (1 and 2), were isolated from the roots of Codonopsis cordifolioidea. Their structures were elucidated by spectroscopic methods, including extensive 1D‐ and 2D‐NMR techniques. Compounds 1 and 2 were tested for their anti‐HIV‐1 activities and anti‐tobacco mosaic virus activities. The results showed that compounds 1 and 2 have modest anti‐HIV‐1 activities and anti‐tobacco mosaic virus activities, respectively.     

Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold

We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.     

Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position

The role of inflammation in cancer generation is gaining importance in the field of cancer research. The chemo‐anti‐inflammatory strategy that involves using non‐steroidal anti‐inflammatory drug compounds as effective anti‐tumor agents is being acceded globally. In the present study, seven new Pt (IV) complexes based on cisplatin, carboplatin and oxaliplatin scaffold bearing the anti‐inflammatory drug naproxen in the axial position were synthesized and characterized by elemental analysis, ESI‐MS, Fourier transform‐infrared, ¹H‐ and ¹⁹⁵Pt‐NMR spectroscopy. The reduction behavior in the presence of ascorbic acid was studied using high‐performance liquid chromatography. The cytotoxicity against two human breast cell lines and the anti‐inflammatory properties were evaluated. All the complexes are able to promote a comparable activity, with average three‐ and 13‐fold more cytotoxic than cisplatin against MCF7 and MDA‐MB‐231 cell lines, respectively. The complexes show remarkable anti‐inflammatory effects, which indicated their potential in treating cancer associated with inflammation and reducing side‐effects of chemotherapy.     

Folding pathways of human telomeric type-1 and type-2 G-quadruplex structures

We have investigated new folding pathways of human telomeric type-1 and type-2 G-quadruplex conformations via intermediate hairpin and triplex structures. The stabilization energies calculated by ab initio methods evidenced the formation of a hairpin structure with Hoogsteen GG base pairs. Further calculations revealed that the G-triplet is more stable than the hairpin conformation and equally stable when compared to the G-tetrad. This indicated the possibility of a triplex intermediate. The overall folding is facilitated by K(+) association in each step, as it decreases the electrostatic repulsion. The K(+) binding site was identified by molecular dynamics simulations. We then focused on the syn/anti arrangement and found that the anti conformation of deoxyguanosine is more stable than the syn conformation, which indicated that folding would increase the number of anti conformations. The K(+) binding to a hairpin near the second lateral TTA loop was found to be preferable, considering entropic effects. Stacking of G-tetrads with the same conformation (anti/anti or syn/syn) is more stable than mixed stacking (anti/syn and vice versa). These results suggest the formation of type-1 and type-2 G-quadruplex structures with the possibility of hairpin and triplex intermediates.     

Synthesis and stereodynamics of highly constrained 1,8-bis(2,2'-dialkyl-4,4'-diquinolyl)naphthalenes

The syn and anti isomers of axially chiral 1,8-diquinolylnaphthalenes have been synthesized via Pd-catalyzed Stille coupling of 1,8-dibromonaphthalene and 2-alkyl-4-trimethylstannylquinolines. Optimization of the cross-coupling reaction allowed the preparation of highly constrained 1,8-bis(2,2'-dimethyl-4,4'-diquinolyl)naphthalene, 2, and 1,8-bis(2,2'-diisopropyl-4,4'-diquinolyl)naphthalene, 3, in 42% and 41% yield, respectively. Employing Pd(PPh(3))(4) and CuO as the cocatalysts in the coupling reaction of 1,8-dibromonaphthalene and 2-alkyl-4-trimethylstannylquinolines proved to be superior over other catalysts such as PdCl(2)(dppf), Pd(2)(dba)(3)/P(t-Bu)(3), and POPd. The C(2)-symmetric anti isomers of 2 and 3 were found to be more stable than the corresponding meso syn isomer. The ratio of the two enantiomeric anti conformers to the syn conformer was determined as 7.9:1 for 2 and 8.6:1 for 3 by NMR and HPLC analysis. The atropisomers of 2 and 3 were found to be stable to rotation about the chiral axis at room temperature and all three stereoisomers of 2 were isolated by semipreparative HPLC on a Chiralpak AD column. The diastereoisomers of 3 were separated via preferential crystallization of the anti isomers from diethyl ether. Slow syn/anti interconversion was observed for both atropisomers at enhanced temperature, and the diastereomerization and enantiomerization processes were monitored by NMR and HPLC. The Gibbs activation energy, DeltaG++, for the isomerization of 2 was determined as 116.0 (112.1) kJ/mol for the conversion of the anti (syn) to the syn (anti) isomer at 71.0 degrees C. The rotational energy barrier of 3 was determined as 115.2 (111.1) kJ/mol for the conversion of the anti (syn) to the syn (anti) isomer at 66.2 degrees C.