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番荔枝内酯————明日抗癌之星 总被引:8,自引:3,他引:8
本文介绍一类近年来被发现于番荔枝科(Annonaceae)植物中的强抗肿瘤活性化合物----番荔枝内酯(annonaceousacetogenin) , 从这类化合物的结构特点, 生理活性, 生源假说, 化学合成等几个方面综述了在该领域的氧基状况 . 相似文献
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A new sesquiterpene, named baccharisketone (1), and a new monoterpene, p-methoxythymol acetate (2), were isolated from the leaves of Baccharis dracunculifolia along with seventeen known compounds (3-19). The structures of the new compounds were determined by spectroscopic means. The growth inhibitory activity of the isolated compounds against leukemia cells (L 1210) was tested and three terpene phenols (4, 6, 17) and five sesquiterpene alcohols (8, 10, 11, 13, 16) were found to exhibit strong cytotoxic activity. 相似文献
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Isolation and structure determination of six glucocerebrosides from the starfish Luidia maculata 总被引:1,自引:0,他引:1
Two new glucocerebrosides, luidiacerebroside A (2) and B (6), were isolated from the cerebroside molecular species obtained from the less polar fraction of the CHCl3/MeOH extract of the starfish Luidia maculata using HPLC. Four known cerebrosides, CE-2b (1), astrocerebroside B (3), acanthacerebroside B (4), and CE-3-2 (5) have also been isolated and characterized. The structures of these cerebrosides were determined on the basis of chemical and spectroscopic evidence. Mass spectrometry of dimethyl disulfide derivatives was useful for the determination of the double-bond position in the long-chain base. 相似文献
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A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells. 相似文献
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Pancharoen O Athipornchai A Panthong A Taylor WC 《Chemical & pharmaceutical bulletin》2008,56(6):835-838
A new isoflavone, 4'-gamma,gamma-dimethylallyloxy-5,7,2',5'-tetramethoxyisoflavone, brandisianin A (1), was isolated from the leaves of Millettia brandisiana, along with one synthetically known isoflavone, 7,4'-di-O-prenylgenistein (2) and twelve known compounds. The structures were elucidated on the basis of extensive spectroscopic analysis. Two isolated compounds were tested for anti-inflammatory activity; 12a-hydroxy-alpha-toxicarol (11) showed significant anti-inflammatory activity. 相似文献
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Hidayat Hussain Natalia Root Farah Jabeen Ahmed Al-Harrasi Ahmed Al-Rawahi Manzoor Ahmad Zahid Hassan Ghulam Abbas Fazal Mabood Afzal Shah Amin Badshah Amjad Khan Riaz Ahmad Ivan R. Green Siegfried Draeger Barbara Schul Karsten Krohn 《中国化学快报》2014,25(12):1577-1579
A new metabolite,named seimatoric acid(1),representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-enone(2),(-)-phyllostine(3),(+)-epiepoxydon(4) and(+)-epoxydon monoacetate(5).Similarly one new benzoic acid derivative,named colletonoic acid(6) was isolated from the ethyl acetate fraction of Colletotrichum sp.The structures of the new compounds were elucidated by detailed ~1 H NMR,~(13)C NMR,COSY,HMQC.HMBC spectroscopic analysis,and HR-E1-MS.Seimatoric acid(1)was also isolated from another taxonomical unidentified fungal strain 4295 in ourgroup.The structures of the known compounds were elucidated by their spectral data comparison to literature data.Preliminary studies showed that colletonoic acid(6) showed good antibacterial,antifungal,and antialgal activities. 相似文献
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One new C-methyl flavanone glucoside, farrerol 4'-O-β-D-glucopyranoside (1) was isolated from the aerial parts of Diplomorpha canescens (MEISN.) C. A. MEYER. Fourteen known phenolic compounds such as farrerol (2), luteolin 7-methyl ether 5-O-β-D-glucopyranoside (3), (-)-pinoresinol (4), (-)-lariciresinol (5), (-)-dihydrosesamin (6), (±)-dehydrodiconiferyl alcohol (7), rutarensin (8), umbelliferone (9), coniferyl aldehyde (10), sinapyl aldehyde (11), p-coumaric acid methyl ester (12), p-hydroxybenzaldehyde (13), p-hydroxyacetophenone (14) and syringaldehyde (15) were also isolated for the first time from this plant. Structure of 1 was determined on the basis of spectroscopic data including two dimensional (2D)-NMR, circular dichroism (CD) and by the application of Klyne's rule. 相似文献
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Seven new compounds, sodium aristolochate-VII (1), aristolactam-CIV (2), madolin-I (3), -J (4), -K (5), -L (6) and -M (7) together with 71 known compounds were isolated and characterized from the fresh root and stem of Aristolochia heterophylla Hemsl. Their structures were determined by spectral methods. Compound 8 was revised as aromadendrane-4beta, 10beta-diol by spectral data and single-crystal X-ray analysis. 相似文献
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Al-Howiriny TA Al-Rehaily AJ Polsc JR Porter JR Mossa JS Ahmed B 《Natural product research》2005,19(3):253-265
Three new diterpenes, namely jasonin-a (1), jasonin-b (2), and jasonin-c (3) were isolated from the aerial parts of Jasonia montana (Asteraceae). Their structures were elucidated on the basis of spectral data as [(1E)-2-((2S)-1,2,5-trimethylbicyclo[3.2.l]octan-8-yl)vinyl] benzene-3-carboxylic acid (1), [3-((2S, 5S)-1,2, 5-trimethylcycloheptanyl)propyl]benzene-3-carboxylic acid (2), and [(1E)-3-((7R)-1,7-dimethy-4-methylenecycloheptanyl)prop-1-enyl] benzene-3-carboxylic acid (3). In addition, the previously reported 5,7,3'-trihydroxy-3,6,4'-trimethoxy flavone designated as centaureidin (4), was also isolated and characterized from this source. The different extracts of the plant were also screened for hypoglycemic, antidiabetic, and antimicrobial activities, wherein the petroleum ether and ethanolic extracts exhibited hypoglycemic and antidiabetic activity, and the petroleum ether and chloroform extracts showed antimicrobial activity. 相似文献
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Ten compounds, neopulchellin (1), 6α- hydroxyneopulchellin (2), β-sitosterol-3-O-β-D-glucoside (3), apigenin (4), quercitin (5), eupafolin (6), kaempferol-3-methoxy-7-O-α-L-rhamnoside (7), apigenin-7-O-β-D-glucopyranoside (8), α-amyrin (9) and β-sitosterol (10), were isolated from the leaves of Gaillardia aristata by applying bioassay guided fractionation. The cytotoxicity was traced against two human cancer cell lines (breast (MCF7) and colon (HCT116)). The highest cytotoxicity was revealed by compounds 1 and 2 (isolated from chloroform extract); with IC(50) values of 0.43, 0.32?μg?mL(-1) against MCF7 and 0.46, 0.34?μg?mL(-1) against HCT116, respectively. Compounds 9 and 10 (isolated from the n-hexane extract) exhibited lower IC(50) values of 3.05, 2.35?μg?mL(-1) against MCF7 and 3.05, 2.35?μg?mL(-1) against HCT116, respectively, while compounds 4-7 obtained from the ethyl acetate extract revealed the lowest cytotoxicity. Identification of the aforementioned compounds was carried out on the basis of their physico-chemical properties and spectral analysis (UV, EI/MS, 1D and 2D). 相似文献
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An iridoid glucoside dimer and a non-glycosidic iridoid from the leaves of Lasianthus wallichii 总被引:1,自引:0,他引:1
Takeda Y Shimidzu H Mizuno K Inouchi S Masuda T Hirata E Shinzato T Aramoto M Otsuka H 《Chemical & pharmaceutical bulletin》2002,50(10):1395-1397
A new iridoid glucoside dimer (1) and a non-glycosidic iridoid (2) was isolated together with the known compounds, asperuloside (3), paederoside (4), daphylloside (5), citroside A (6) and benzyl 6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside (7), from the leaves of Lasianthus wallichii. The structures of the new compounds were elucidated by spectroscopic and chemical evidence. 相似文献