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3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及其杀菌活性的研究 总被引:4,自引:0,他引:4
以5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮(1)、芳胺(2)和原甲酸三乙酯进行缩合反应,合成了20个3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮(3).由于分子内氢键的形成,化合物3由一对构象异构体4和5组成.生物活性初步测定结果表明,这些化合物均有一定的杀菌活性. 相似文献
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3—芳胺甲烯基—6—烷基(芳基)_5,6—二氢—2H—吡喃—2,4—二 … 总被引:1,自引:0,他引:1
以5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮(1)、芳胺(2)和原甲酸三乙酸进行缩合反应、合成了20个3-芳胺甲烯基-6-烷基(芳基)-5,6-二 喃-2,4-二酮(3),由于分子内氢键的合成,化合物3由一对构象异构体4和5组成,生物活性初步测定结果表明,这些化合物均有一定的杀菌活性。 相似文献
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2-甲基-3-芳基-7-(5,5-二甲基-3-酮-1-环己烯-1-基)甲酸酯-4(3H)-喹唑啉酮的合成 总被引:5,自引:0,他引:5
以2-氨基对苯二甲酸(1)为起始原料,与乙酸酐缩合生成7-羧基乙酰苯邻 甲内酰胺(2);2和芳胺缩合产生7-羧基-2-甲基-3-芳基-4(3H)-喹唑啉 酮(3);3和N,N-双环己基碳双亚胺(DCC)加成得到中间体4,4在4-二甲氨基 吡啶(DMAP)催化下和5,5-二甲基-1,3-环己二酮(5)缩合得到目标产物2- 甲基-3-芳基-7-(5,5-二甲基-3-酮-1-环己烯-1-基)甲酸酯-4( 3H)-喹唑啉酮(6)。所得15个新型化合物的结构均经^1H NMR、元素分析确证, 部分化合物经IC/MSD确证。 相似文献
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Abstract Recently we have reported isoflavone derivatives as potential mesogens [1]. During the synthesis of isoflavone derivatives, 2,4-dihydroxyphenyl benzyl ketone was synthesized as an intermediate. Nguyen Huu Tinh et al. [2] have reported the effect of the influence of the central linkage, such as ethylene, methylene ketone and ketone on the mesogenic compounds. Vora et al. [3] have also reported a mesogenic homologous series with terminal and lateral phenolic groups. To understand the effect of hydrogen bonding originating between methylene ketone and free lateral hydroxy groups, ortho to the methylene ketone group, on mesogenicity, the present homologous series of 2-hydroxy, 4(4′-n-alkoxybenzoyloxy)phenyl benzyl ketone was synthesized. The synthesized compounds were characterized by elemental analysis and spectroscopic techniques. The first six homologues of the present series are non-mesogenic and mesomorphism appears from the heptyl derivative onwards. The present series shows a monotropic smectic A phase except for the last member (octadecyloxy) which exhibits an enantiotropic smectic A mesophase. The transition temperatures are also identified using DSC. The fluorescent studies of some of the compounds of the present series are under investigation. 相似文献
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环丙基甲基酮是合成环丙氟哌酸类广谱抗菌药物和抗艾滋特效药依法韦仑的重要中间体,在医药、化工及农林等领域均有广泛应用。环丙基甲基酮的合成方法大致分为4类,分别以酮类、酯类、醇类及呋喃有机物为原料,在一定条件下生成环丙基甲基酮粗品,经萃取及精馏得到环丙基甲基酮纯品。本文综述了环丙基甲基酮的合成研究进展。 相似文献
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《化学:亚洲杂志》2017,12(12):1301-1304
Intermolecular oxidative cross‐coupling of two different enolates is one of the most useful reactions to synthesize unsymmetrical 1,4‐dicarbonyl compounds. In this study, the oxovanadium(V)‐induced intermolecular oxidative cross‐coupling of enolates afforded unsymmetrical 1,4‐dicarbonyl compounds. Various boron and silyl enolates underwent the formation of ketone–ester, ester–ketone, ester–ester, amide–ketone and amide–ester coupling products . These results clearly show the versatility of the present oxidative cross‐coupling protocol. 相似文献
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Titanium tetraiodide promotes an aza-Reformatsky-type reaction of alpha-iodomethyl ketone O-alkyl oximes with carbonyl compounds to give beta-hydroxy ketone O-alkyl oximes in good to high yields. 相似文献
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Helena Dodziuk 《Journal of Molecular Structure》1974,20(3):363-371
Based on the earlier results on methylated butadienes and acroleins, the conformational analysis of methylvinyl ketone was performed using the Wiberg method. The effect of nonbonded interactions involving the methyl group on the molecular geometry was estimated. In agreement with experimental findings the larger amount of the s-cis than s-trans conformer in methylvinyl ketone vs. acrolein is thought to be due to steric hindrance. Contrary to the situation for other unsaturated compounds, the rotation of the methyl group in the s-trans conformer of methylvinyl ketone seems to be determined mainly by nonbonded interactions. The barrier to internal rotation of the methyl group in the s-cis compared to the s-trans conformation seems to be considerably less. The present analysis of the steric properties of methylvinyl ketone seems to indicate that the spectral arguments in favour of nonplanarity of β-N,N-dimethylaminovinyl ketone are equivocal. 相似文献
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Mitsunori Honda Kenta NakaeToshiaki Nishizawa Mitsuhiro SudaKo-Ki Kunimoto Masahito Segi 《Tetrahedron》2011,67(49):9500-9508
The reaction of silylcyclopropyl bromides with dichloromethyl methyl ether in the presence of n-butyllithium is investigated. Under basic reaction conditions, the corresponding cyclopropylidene derivatives are exclusively obtained. The resulting cyclopropylidene compounds are subjected to protonolysis or trapping with electrophiles in a one-pot to give the cyclopropyl silyl ketone derivatives in good yields. Acidic treatment of derived cyclopropyl silyl ketone allows isomerization to give the thermodynamically favorable trans form exclusively. 相似文献
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Certain aldehyde and ketone compounds can be used as indicators, at a molecular level, of the oxidized flavor of milk powder instead of sensory evaluation. This study investigated the formation of aldehyde and ketone compounds as affected by the heat-related processing and storage of milk powder. The compounds were extracted by solid phase microextraction fiber and determined using gas chromatography-mass spectrometry. In the results, higher contents of hexanal, 2-heptanone, octanal and 3-octen-2-one were detected in concentrated milk and fresh milk powders than in raw milk and heated milk. The levels of these compounds increased with increasing time of storage of milk powder. Meanwhile, the DPPH radical scavenging activity decreased and peroxide value increased during the production and storage of milk powder. In addition, the pore volume distribution of milk powder particle was determined by nitrogen isotherm adsorption. The porosity of milk powder was significantly correlated to the changes of aldehyde and ketone compounds during storages periods of 3 months (r > 0.689, p < 0.05) and 6 months (r > 0.806, p < 0.01). Therefore attention should be paid to the detectable aldehyde and ketone molecules to control the oxidized flavor, which was influenced by pre-heating as well as concentration and drying during milk powder production. 相似文献
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Mercury(II)-chloride reacts with anhydrous methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone in a precise stoichiometry ratio (1:2), and weakly ionized compounds of mercury with ketones are formed and equivalent quantity of HCl is released. The application of a mercury anode for the quantitative generation of H+ ions in 0.25 M sodium perchlorate in anhydrous methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone has been investigated. Current/potentials curves for the solvents, titrated bases, indicator and mercury showed that in these solvents mercury is oxidized at potentials much more negative than those for the titrated bases and other components present in the solution. The protons generated in this way have been used for the titration of some organic bases, with either visual or potentiometric end-point detection. The oxidation of mercury in methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone and the reaction of mercury ions with these solvents have been found to proceed with 100% current efficiency. 相似文献