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综述了国内近年来光度分析法在药物分析中的研究与应用情况.就分光光度法、荧光光度法、化学发光法3种重要的分析方法,从反应条件、线性范围、灵敏度等方面介绍了光度分析法对不同反应体系的研究现状,展望了光度分析法在药物分析中的发展方向. 相似文献
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化学发光分析法应用进展 总被引:6,自引:0,他引:6
对近年来化学发光分析法的研究应用最新进展作了评述,包括化学发光试剂的类型,化学发光在无机、有机及药物分析中的应用,全文引用文献105篇。 相似文献
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小分子药物进入人体血液循环系统后与人血清白蛋白(HSA)、α1 -酸性糖蛋白(AGP)等血浆蛋白存在广泛的相互作用,这些相互作用深刻影响药物在体内的分布及其与靶标蛋白的结合,进而影响药物效应的发挥。深入探究药物与血浆蛋白间的相互作用对于候选药物的成药性优化、新药研发、联合用药的风险评控等意义重大。而发展高效、灵敏、准确的分析检测方法是开展药物-血浆蛋白相互作用研究的关键。近年来,色谱技术由于其高通量、高分离性能、高灵敏度等特点在该领域得到了广泛的应用,包括测定血浆蛋白翻译后修饰对药物结合的影响,多种药物的竞争性结合等。其中,高效亲和色谱(HPAC)和毛细管电泳(CE)应用最为广泛,能够通过多种分析方法获取结合常数、结合位点数、解离速率常数等相互作用信息。该文着重综述了HPAC和CE在药物-血浆蛋白相互作用研究中的常用策略及最新研究进展,包括HPAC中常用的前沿色谱法、竞争洗脱法、超快亲和提取法、峰值分析法和峰衰减分析法,以及CE中常用的亲和毛细管电泳法(ACE)和毛细管电泳前沿分析法(CE-FA)等。最后,该文还对当前色谱方法存在的不足进行了总结,并对色谱技术在药物-血浆蛋白相互作用研究领域的应用前景和发展方向进行了展望。 相似文献
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温度敏感性材料由于其理化性质对温度变化高度敏感,同时相变温度又易于调控,因而成为条件响应型药物控释载体中的研究热点。多种类型的温敏性药物载体,包括脂质体、聚合物囊泡、聚合物胶束,经过多年的研究和优化,其稳定性得到进一步的提高,而相变温度也实现了在较宽范围内的随意调整,可同时适用于病理性的高热和局部人工热疗等多种方式的温敏靶向性释药。并且,由于局部热疗可以有效控制温敏载体的药物释放,同时,热疗还能有效增强化疗药物的细胞毒性,因此温敏药物载体在肿瘤化疗和热化疗领域具有独特的应用潜力。本综述简要回顾了温敏性载体在药物载体领域的研究现状。在此基础上,从对肿瘤热化疗原理、发展现状、疗效影响因素的角度,进一步综述了温敏性药物载体在肿瘤热化疗领域的研究进展,特别关注了复合型温敏载体,因为这类载体结合了具有光热/磁热效应的纳米颗粒而兼具自升温能力,因而在靶向性热化疗中独具优势。最后,本文结合热化疗的影响因素,对温敏性载体在肿瘤热化疗领域的发展方向进行了展望。 相似文献
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药物对福氏志贺氏菌代谢抑制的微量热法研究 总被引:11,自引:1,他引:11
药物抑制细菌生长的热化学研究是当今热化学法研究的一个活跃领域.在这项研究中,Boling[1]、Nordmark[2]、屈松生[3]等人已做了不少有意义的工作.在前人工作的基础上,我们用热活性检测系统测定了福氏志贺氏菌属中五株细菌在药物抑制下生长的完整的热谱曲线.按指数生长模型计算出细菌代谢抑制下的生长速车常数,并用计算机拟会出生长速率常数与不同浓度药物之间的关系式,进一步得到生长速率常数为零(临界生长参数[4])时的用药物浓度.此项研究工作的开展对于深入研究药物对细菌的抑制作用,筛选对某细菌抑制的特效药提供了一种新的… 相似文献
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de Souza Nadábia A. B. de Souza F. S. Basílio I. D. Medeiros Ana C. D. Oliveira E. J. Santos Ana F. O. Macwdo R. O. Macędo R. O. 《Journal of Thermal Analysis and Calorimetry》2003,72(2):535-538
TG and DSC data were used to determine the thermal parameters of metronidazole drug and tablets. Three tablets A, B and C
were analysed. The TG curves of metronidazole drug and tablets A and B displayed five and C four thermal decomposition processes,
respectively. Analysis of the DSC data pointed to chemical interactions between metronidazole drug and the excipients of tablets,
suggested by alterations in the melting point of metronidazole. The rate constants obtained from the isothermal TG data presents
following sequence of the thermal stability: tablet A>tablet C>metronidazole drug>tablet B.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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The characterization of the thermal properties of polymers represents a fundamental step in improving materials for energy harvesting processes. Thermal conductivity, for example, is measured by measuring heat flux and temperature difference. This study seeks to design and fabricate an experimental set-up to measure the thermal conductivity of low-thickness polymers at room temperature. It is unique in that it is an affordable and lightweight instrument developed using electrical resistance as a heater and a limited number of components. Error analysis and reproducibility analysis were carried out for the thermal conductivity. The instrument was found to be reliable in making thermal conductivity measurements with an average of ±7%. 相似文献
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To reveal the fire injuring of parchment, the changes in the thermal behaviour of some goat parchments, obtained from skins
originating from different animals, as a result of thermal aging were determined by thermal analysis methods (DSC; simultaneous
TG/DTG, DSC; micro hot table (MHT)). Thermal aging of parchments was revealed to bring about the decrease in shrinkage temperature,
absolute value of enthalpy of denaturation in water and some changes in non-isothermal parameters characteristic for dehydration
process in static air atmosphere.
The results obtained by DSC analysis performed in N2 and O2 flows as well as those obtained by simultaneous TG/DTG, DSC analyses have shown that both softening (melting) process parameters
and parameters of thermo-oxidative processes have not been changed by thermal ageing. The results obtained by thermal analysis
methods were correlated with those obtained by microscopic investigation of parchment samples immersed in water and scanning
electron microscopy (SEM). The application of these microscopic techniques has revealed the morphology changes in the investigated
parchments as a result of thermal degradation. 相似文献
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This article discusses AFM-based localized thermal analysis of crosslinked polymer coatings based on a recent breakthrough
in nanoscale thermal probe technology. The addition of a thermal tip to a conventional AFM adds a new and valuable capability
of spatially resolved thermal analysis to the AFM. It is particularly useful for thin films since it enables the measurement
of transition temperatures (melting (T
m) or glass (T
g)) on selected regions of the sample aiding in the identification and characterization of phases on the length scales approaching
macromolecular dimensions. Examples include the monitoring of the softening point of automotive clearcoat systems, as a function
of cure time and cure temperature and characterization of degradation and embrittlement of weathered acrylic-polyurethane
coatings. Comparison of nano thermal analysis with bulk DSC and MDSC is made and its inherent advantages over DSC in analyzing
surfaces, is demonstrated. 相似文献
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A. C. D. de Medeiros N. A. B. de Cervantes A. P. B. Gomes R. O. Macêdo 《Journal of Thermal Analysis and Calorimetry》2001,64(2):745-750
TG and DSC data were used to determine the thermal parameters of prednisone drug and tablets. Two formulations of prednisone
20 mg were analysed in the form of tablets. The TG curves of prednisone drug and tablets A and B displayed six, eight and
seven thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between prednisone
drug and the excipients of tablets A and B, suggested by alterations in the melting temperature of prednisone. The analysis
revealed that prednisone drug is more stable than tablets A and B.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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H.-S. Yang M. P. Wolcott H.-S. Kim H.-J. Kim 《Journal of Thermal Analysis and Calorimetry》2005,82(1):157-160
Summary In the TG analysis of the bio-composites, their thermal stability was found to slightly decrease and the ash content to increase
as the lignocellulosic filler loading increased. This is a logical consequence of the lower thermal stability of the lignocellulosic
filler compared to that of the matrix polymer. The dispersion and interfacial adhesion between the lignocellulosic filler
and thermoplastic polymer were important factors affecting the thermal stability of the composite system. In order to improve
their compatibility and interfacial adhesion, the incorporation of a compatibilizing agent into the lignocellulosic material-thermoplastic
polymer composites is recommended. In the TMA analysis, the thermal expansion of the composites was found to decrease with
increasing filler loading and incorporating compatibilizing agent. Lignocellulosic filler is a suitable material for preventing
the thermal expansion of the composite materials caused by atmospheric changes. 相似文献
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基于热重分析、微商热重分析及示差热分析研究了N,N′-二苯胺基己二酰胺β-晶型成核剂在空气气氛中的热分解动力学;通过利用Friedman方程和Flynn-Wall-Ozawa(FWO)方程对其热分解过程进行动力学分析求得了其热分解表观活化能;同时利用Achar-Brindly-Sharp方程和Coats-Redfern方程研究了其热分解机理,用等温热重分析法测得了失重10%时的寿命方程.结果表明,N,N′-二苯胺基己二酰胺β-晶型成核剂的表观活化能为138.66kJ.mol-1,其热分解反应的机理函数符合Mample法则,反应级数n=3/2,动力学方程为G(α)=α3/2,寿命方程为:lnτ=-51.877+2.922 2×104/T. 相似文献
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D. M. Price M. Reading A. Hammiche H. M. Pollock 《Journal of Thermal Analysis and Calorimetry》2000,60(3):723-733
This paper describes recent advances in thermal analysis instrumentation which combine the high resolution imaging capabilities
of the atomic force microscope with physical characterisation by thermal analysis. Images of the surface may be obtained according
to the specimen's thermal conductivity and thermal expansivity differences in addition to the usual topographic relief. Localised
equivalents of modulated temperature differential scanning calorimetry, thermomechanical and dynamic mechanical analysis have
been developed with a spatial resolution of a few micrometres. A form of localised thermogravimetry-evolved gas analysis has
also been demonstrated. The same instrument configuration can be adapted to allow IR microspectrometry at a resolution better
than the optical diffraction limit.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
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The thermal diffusivity and the thermal conductivity of polypropylene-based composite polymer were simultaneously measured
with a temperature wave analysis method. We can measure the thermal properties under cooling process which are important to
consider the polymer processing. The effect of filler in the composite was analyzed by thermal diffusivity and thermal conductivity
as a function of temperature. The thermal conductivity of particle dispersed composite was confirmed as a reasonable value
and was explained with a series model.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Effect of thermal decomposition processes on the thermal properties of carbon fiber reinforced cement composites in high-temperature range 总被引:1,自引:0,他引:1
R. Černý Jitka Němečková Pavla Rovnaníková P. Bayer 《Journal of Thermal Analysis and Calorimetry》2007,90(2):475-488
Thermal conductivity, specific heat capacity, thermal diffusivity and linear thermal expansion coefficient of two types of
carbon fiber reinforced cement composites are measured in the temperature range up to 800°C. Thermal conductivity and thermal
diffusivity are also determined for the specimens exposed to thermal load up to 800°C before the measurement. Differential
thermal analysis (DTA), mercury intrusion porosimetry (MIP), scanning electron microscopy (SEM) and X-ray diffraction analysis
(XRD) are utilized for the assessment of thermal decomposition processes taking place in the high temperature range under
consideration.
The high temperature thermal properties of the studied materials are found to be positively affected by the application of
the high alumina cement and in the case of the Portland cement based composite also by using the autoclaving procedure in
the production process. Also, the randomly distributed carbon fibers that can reduce the damage of the pore structure by the
thermal decomposition processes are identified as a positive factor in this respect. A comparison of thermal conductivity
vs. temperature curves obtained for the specimens pre-heated to different temperatures is found to be a useful tool in the identification
of major dynamic effects in the specimens due to the thermal decomposition reactions. The results are in a good agreement
with the DTA, MIP, SEM and XRD analyses. The character of the thermal conductivity measurements that in fact includes the
effects of convection and radiation into the thermal conductivity coefficient can be beneficial for a simple assessment of
the influence of the fire on a dividing structure. 相似文献