2-氨甲基吡啶缩5-溴水杨醛席夫碱配合物的合成、表征与抗氧化作用

以乙醇为溶剂合成了2-氨甲基吡啶缩5-溴水杨醛席夫碱(HL,C13H11N2OBr)的Zn(Ⅱ)、Cd(Ⅱ)、Co(Ⅲ)配合物[ZnL2]、[CdL2]和[CoL2]NO3·3H2O,利用红外光谱、紫外光谱、热重分析、元素分析及摩尔电导等方法对配合物的组成和结构进行了表征,探讨了配合物的抗氧化活性.     

超氧化物歧化酶模型化合物的合成、表征及其SOD活性研究

合成了 4种过渡金属硝酸盐与三 (2 苯并咪唑亚甲基 )胺 (ntb)和水杨酸 (Hsal)的新固体配合物 ,经元素分析确定其组成分别为 [M2 (ntb) 2 (Hsal) 2 ](NO3 ) 2 ·H2 O(M =Zn ,Co)、[M2 (ntb) 2 (Hsal) ](NO3 ) 3 ·3H2 O(M =Cu)和 [M(ntb) (Hsal) ](NO3 )·2H2 O(M =Ni) ,进行了摩尔电导率、热重、红外与紫外可见光谱、1HNMR等性质的表征。研究了配合物的模拟SOD活性 ,用IC50 表征配合物的模拟SOD活性的大小。     

乙酰基吡啶Schiff碱Cu(Ⅱ),Ni(Ⅱ)配合物的合成与表征

制备了乙酰基吡啶缩乙二胺Sch iff碱L及其N i(Ⅱ)和Cu(Ⅱ)的配合物,经元素分析、IR光谱、UV-V is光谱、电导率和热分析表征,确定了配合物组成分别为[CuL](NO3)2.0.5H2O和[N iL](NO3)2.H2O.     

1，4，7-三氮环壬烷衍生物铜、锌配合物切割DNA及催化对硝基苯磷酸单酯水解

系统研究了1,4,7-三(2-羟基丙基)-1,4,7-三氮环壬烷(L1)和1,2-双[N,N′-二(2-羟基丙基)-1,4,7-三氮杂环壬基]乙烷(L2)铜配合物([CuL1](ClO4)(NO3)和[Cu2L2](ClO4)4])以及锌配合物([ZnL1](ClO4)2)与CT-DNA的相互作用以及核酸酶活性和催化磷酸酯水解功能。两个铜配合物对DNA切割具有浓度、时间和pH依赖性。荧光和CD光谱实验表明[Cu2L2](ClO4)4能插入DNA双螺旋中。配位饱和的[ZnL1](ClO4)2和[Cu2L2](ClO4)4能催化对硝基苯磷酸单酯水解生成对硝基苯,[ZnL1](ClO4)2和[Cu2L2](ClO4)4催化磷酸单酯水解的表观一级反应速率常数分别为2.8×10-5min-1和5.9×10-6min-1。     

镉(Ⅱ)、锌(Ⅱ)与2-乙酰吡啶缩邻氨基苯甲酰腙配合物合成及晶体结构

采用Schiff碱配体2-乙酰吡啶缩邻氨基苯甲酰腙(L)分别与Cd(NO3)2·4H2O和Zn(CH3COO)2·2H2O进行配位反应,得到2个配合物[Cd L(NO3)2·H2O](1)和[Zn L2](2)。分别采用1H NMR、FTIR和元素分析等手段对化合物进行了表征,并测定了2个配合物的单晶结构。结构解析表明,配合物1属于单斜晶系,P21/n空间群,配合物2属于单斜晶系,P21/c空间群。对配体和配合物的体外抑菌活性进行了初步考察,结果表明,配体L和配合物1具有一定的抑菌活性。     

抗衡阴离子PF6-调控的1,3-丙二胺缩邻香兰素镧(Ⅲ)配合物的合成和晶体结构

通过柔性配体1,3-丙二胺缩邻香兰素(H2L)与和La(NO3)3.6H2O反应,合成了1个由2个H2L桥连的双核稀土配合物[La2(NO3)6(H2L)2].CH2Cl2(1),该配合物与(NH4)(PF6)继续反应生成了1个由2个NO3-离子桥连的双核配合物[La2(NO3)2(H2L)4](PF6)4.4H2O.2CH2Cl2(2),X-射线单晶衍射分析确定了2个配合物的晶体结构。配合物1和2为结构完全不同的2个双核结构,因抗衡阴离子PF6-有去阴离子的作用,配合物1中的NO3-离子被配体取代,导致配合物1的结构翻转,形成了1个新颖的双核结构2。     

双吡啶化合物3，7-di(3-pyridyl)-1，5-dioxa-3，7-diazacyclooctane构建的四个过渡金属配合物的合成、结构及热稳定性

采用准刚性的双吡啶化合物3,7-di(3-pyridyl)-1,5-dioxa-3,7-diazacyclooctane(L),合成了4个过渡金属配合物[Co(NO3)(H2O)2(L)2]NO3(1)、[Co2Cl4(L)2]·CH2Cl2(2)、[Cd2(AcO)4(L)2]·4CH3OH(3)和[Cd2(NO3)2(CH3OH)2(H2O)2(L)2](NO3)2·2H2O(4)。单晶衍射分析表明,配合物1是单核结构,配合物2是24-元环状双核结构,而配合物3和4为多边形双核结构。在这些配合物中,双吡啶配体分别采用了单齿、trans-和cis-桥连3种不同配位方式。配合物经过了元素分析、红外、热重和X射线单晶结构分析表征。     

糠醛缩对苯二胺与Ln(Ⅲ)配合物的合成、表征及热分解动力学

合成了三种新的希夫碱配合物[LnL2(NO3)2(H2O)2](H2O)(C2H5OH), [Ln(Ⅲ) = Nd, Gd, Dy; L=糠醛缩对苯二胺].通过元素分析、IR、 UV和摩尔电导分析等手段, 对合成的配合物进行了表征, 并用非等温热重法研究了钆配合物的热分解反应动力学. 推断出第三步热分解动力学方程为 dα/dt = A*e-E/RT*3 / 2 (1-α)4/3 [1 / (1-α)1/3-1]-1.     

[Cu2(C2O4)(C12H8N2)2(C3H7NO)2](ClO4)2配合物的合成及其热分解

以邻菲罗啉、2,5二羟基-1,4-二噻烷和Cu(ClO4)2.6H2O为原料,合成了中心对称的双核配合物[Cu2(C2O4)(C12H,N2)2(C3 H7NO)2](ClO4)2(1).通过红外光谱、元素分析等分析测试手段对其进行了表征;借助TG-DTG技术在氮气气氛下研究了配合物的热分解情况,并根据热分析结果确定了...     

2-氨基吡啶缩水杨醛及稀土金属配合物的合成及表征

制备了2-氨基吡啶缩水杨醛Schiff碱及其稀土金属(La,Ce)配合物,经元素分析、红外光谱、紫外光谱、电导率、热分析和荧光性等表征,确定了配合物的组成分别为[La2(H2O)2L4](NO3)2,[Ce2(H2O)2L4](NO3)2,其中HL=C12H10ON2。配体和配合物都具有一定的荧光性能,其中以配体的荧光性好于配合物的荧光性。     

水、氯配位的Shiff碱单核及双核锰化合物的合成与结构表征

在水杨醛与二元胺形成的Schiff碱与Mn盐的反应体系中分离出两个单核Mn化合 物,(salen)Mn(H_2O)Cl(1)和[(salpr)Mn(H_2O)_2]Cl(2),并测定了结构。应用对 苯二甲酸在碱性条件下拉接两个单核Mn的Schiff碱配位单元,生成(salen)_2Mn_2 [μ-p-C_6H_4(COO)_2](H_2O)(CH_3OH)(3)并进行了结构表征。讨论了这些化合物 的红外及~1HNMR谱,揭示了Mn中心对配体信号的影响。     

Synthesis, DNA interaction and antibacterial activities of La(III) and Gd(III) complexes of Schiff base derived from o-vanillin and lysine

Two novel complexes, [La(HL)(H₂O)₂NO₃] · NO₃ · H₂O and [Gd(HL)(H₂O)₂NO₃] · NO₃ · H₂O, where HL is a Schiff base derived from o-vanillin and lysine, have been synthesized and characterized by elemental analysis, conductivity measurements, IR, ¹H NMR and thermogravimetric analyses (TGA). The Schiff base ligand behaves as a tetradentate, coordinating through azomethine nitrogen, phenolic oxygen and two carboxylic oxygen atoms. The interaction of these complexes with calf thymus DNA (CT-DNA) was also investigated by spectrometric titration and viscometric measurements. The faint hypochromism of the complexes in the absorption spectra, the remarkable reduction of fluorescence intensity of ethidium bromide (EB) bound DNA, together with a small decrease in the viscosity of the DNA suggest that a partial intercalation may be the preferred binding mode between these two complexes and DNA. The antibacterial activity testing revealed that the complexes and their precursor Schiff base show a weak to moderate activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli.      

双水杨醛1,10-癸二胺Schiff碱稀土配合物的合成和表征

合成了双水杨醛缩1,10-癸二胺Sch iff碱配体(C24H32N2O2,以L表示)与稀土Ln3+的15种新的固体配合物[LnL(NO3)3].nH2O(Ln=La,Ce,Pr,Nd,Sm,Eu,n=0;Ln=Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y,n=1).利用元素分析、摩尔电导、红外光谱、热分析等方法进行表征.中心金属离子Ln3+与Sch iff碱配体中的酚羟基氧以及硝酸根中的氧发生配位,配位数为8.     

Syntheses, Characterizations, Crystal Structures and Antibacterial Activities of Two Zinc(II) Complexes with a Schiff Base Derived from o-Vanillin and p-Toluidine

Two new zinc(II) complexes, [Zn2L2Cl4]·2[ZnL(CH3OH)Cl2] 1 and [ZnL2(NO3)2] 2, were synthesized by reacting ZnX2·nH2O (X = Cl-, NO3-) and a Schiff base ligand 2-[(4-me- thylphenylimino)methyl]-6-methoxyphenol (C15H15NO2, L) which was obtained by the condensation of o-vanillin (2-hydroxy-3-methoxybenzaldehyde) with p-toluidine. Both 1 and 2 were characterized by single-crystal X-ray diffraction technique, elemental analysis, molar conductance, FT-IR, UV-Vis, 1H-NMR spectra and thermogravimetric analysis. The Schiff base ligand and its zinc(II) complexes have been tested in vitro to evaluate their antibacterial activity against bacteria, viz., Escherichia Coli, Staphylococcus aureus and Bacillus Subtilis. The results show that these complexes have higher activity than the corresponding free Schiff base ligand against the same bacteria.     

Biomolecular docking,antimicrobial and cytotoxic studies on new bidentate schiff base ligand derived metal (II) complexes

Three new metal complexes [Cu(L)₂] (1), [Co(L)₂] (2) and [Zn(L)₂] (3) have been prepared by the reaction of hydrated salts of metal (II) acetate with new Schiff base ligand HL, [2‐((4‐(dimethylamino)phenylimino)methyl)‐4,6‐di‐t‐butylphenol] and characterized by different physico‐chemical analyses such as elemental analysis, single XRD, ¹H NMR, FTIR and UV–Vis spectroscopic techniques. Their biomolecular docking, antimicrobial and cytotoxicity studies have also been demonstrated. The proposed structure of Schiff base ligand HL and complex 2 are confirmed by Single crystal X‐ray crystallography study. This analysis revealed that metal (II) complexes remain in distorted tetrahedral coordination environments. The electronic properties such as HOMO and LUMO energies are carried out by gaseous phase DFT/B3LYP calculations using Gaussian 09 program. Complex 1 showed a good binding propensity to the DNA and HSA, during the assessment of docking studies. Schiff base ligand HL and its metal (II) complexes, 1–3 screened for their in vitro antimicrobial activities using the disc diffusion method against selected microbes. Complex 1 shows higher antimicrobial activity than complexes 2, 3 and Schiff base ligand HL. According to the results obtained from the cytotoxic studies, Schiff base ligand HL and its metal (II) complexes 1–3 have better cytotoxicity against MCF‐7 cell lines with potency higher than the currently used chemotherapeutic agent cyclophosphamide.     

Synthesis and catalytic activity of Ln (<Emphasis Type="Bold">III</Emphasis>) complexes with an unsymmetrical Schiff base including multi groupsgroups

A synthetic method for a new unsymmetrical Schiff base and its Ln (III) complexes including multi groups is reported. The complexes are characterized by elemental analysis, IR spectra, ¹H and¹³C NMR, especially 2D-COSY ¹H, ¹H NMR spectra. The general formula of the obtained complexes is [Ln₃(TBLY)(NO₃)₃]\sdnH₂O (Ln = La, n = 3; Ln = Nd, n=5; Ln = Gd, Dy, Yb, Y, n = 7), where TBLY = tetraglycol aldehyde-2,4-dihydroxy benzaldehyde bis-lysine Schiff base. In addition, the evidence for existence of group is supported by the AM1 method. The complexes obtained may be used as a catalyst. Conversion rate of 80% with the viscosity-average molecular weight 220000 for the polymerization of methyl methacrylate (MMA) without addition of any cocatalyst has been obtained.     

空间不对称席夫碱铜配合物的合成及其与金属卟啉的反应

合成了新型具有空间不对称四齿席夫碱配合物 (Cu[XBP- PHEN- 4 - CHO- Im] ,X=H,Cl,Br,CH3 ;Cu[CBP- PHEN- 2 - CHO- Im] ,C=Cl)。并进行了红外、元素分析、质谱等表征。研究了此类席夫碱铜配合物在二氯甲烷溶剂中与四苯基卟啉锌 (Zn TPP)反应的电子光谱 ,结果表明 ,此类席夫碱铜 ( )配合物可以与锌卟啉发生轴向配位反应。     

Syntheses, Characterizations, Crystal Structures and Antibacterial Activities of Two Zinc(Ⅱ) Complexes with a Schiff Base Derived from o-Vanillin and p-Toluidine

Two new zinc(Ⅱ) complexes, [Zn2L2aCl4]·2[ZnL(CH3OH)Cl2] 1 and [ZnL2(NO3)2] 2,were synthesized by reacting ZnX2·nH2O (X = Cl-, NO3-) and a Schiff base ligand 2-[(4-me-thylphenylimino)methyl]-6-methoxyphenol (C15H15NO2, L) which was obtained by the condensation of o-vanillin (2-hydroxy-3-methoxybenzaldehyde) with p-toluidine. Both 1 and 2 were characterized by single-crystal X-ray diffraction technique, elemental analysis, molar conductance, FT-IR, UV-Vis,1H-NMR spectra and thermogravimetric analysis. The Schiff base ligand and its zinc(Ⅱ) complexes have been tested in vitro to evaluate their antibacterial activity against bacteria, viz., Escherichia Coli,Staphylococcus aureus and Bacillus Subtilis. The results show that these complexes have higher activity than the corresponding free Schiff base ligand against the same bacteria.     

邻香兰素缩对甲苯胺Schiff碱过渡金属配合物的合成、表征、晶体结构及抗菌活性研究

合成了邻香兰素缩对甲苯胺Schiff碱HL(C₁₅H₁₅NO₂)与锰(Ⅱ),锌(Ⅱ)的配合物[Mn(HL)₃(CH₃OH)](ClO₄)₂ (1)和[Zn(HL)₂(H₂O)₂](ClO₄)₂ (2)。用元素分析、红外光谱、紫外-可见光谱、¹H NMR核磁共振、摩尔电导等手段进行表征;用单晶X-射线衍射方法测定了配合物的晶体结构,配合物的中心金属离子与Schiff碱配体中的酚羟基氧及甲氧基氧发生配位,锰(Ⅱ)的配位数为7,而锌(Ⅱ)的配位数为6。测定了配体和配合物对大肠杆菌、金黄色葡萄球菌、枯草杆菌的抗菌活性。     

Synthesis and structural peculiarities of gallium Complexes with novel paullone derivatives

9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-ylhydrazine was reacted with 2-acetylpyridine to give a Schiff base as a potential tridentate ligand. The reaction of this ligand with gallium chloride afforded complexes of 1:1 and 2:1 stoichiometry. The results of X-ray diffraction studies of the ligand and both gallium complexes are reported and compared with the data for a related gallium complex with a Schiff base obtained from 9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-ylhydrazine and 2-hydroxybenzaldehyde.