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1.
磁性高分子微球的制备及其应用   总被引:6,自引:0,他引:6  
张珊  游长江  陶潜  莫海 《广州化学》2004,29(2):45-50
对磁性高分子微球的研究现状进行了综述,探讨了目前的各种合成制备方法、结构性能以及影响微球磁性的因素,在此基础上对磁性高分子微球在免疫测定、生物导弹、有机合成、环境/食品微生物检测等领域的最新应用进展以及存在的问题进行了分析,提出了该领域的今后发展方向。  相似文献   

2.
功能化磁性高分子复合微球作为一种新型功能材料,在许多领域具有广阔的应用前景。本文对近年来功能化磁性高分子复合微球的制备方法进行了总结,对当前不同方法的优缺点进行了评价与分析;对功能化磁性高分子复合微球在生物工程领域,医学领域,环境、食品领域和功能材料领域进行了阐述。并综合分析了磁性微球在各个领域的优势及已经取得的成果。最后,展望了功能化磁性高分子复合微球的发展前景,提出自己的观点,并列出亟待解决的四个问题。  相似文献   

3.
磁性高分子微球的制备和应用研究进展   总被引:29,自引:0,他引:29  
磁性高分子微球是近20年来研究的一类新型功能材料,在生物医学,细胞学和生物工程等领域有着广泛的应用前景,本文对磁性高分子微球的性质,制备方法及功能经方法作了详细评述,介绍了磁性高分子微球在细胞分离,固定化酶,免疫测定,生物导弹,DNA分离及核酸杂交等领域的应用。  相似文献   

4.
磁性聚合物微球作为一种新兴起的复合功能材料,由于具有纳米尺寸、超顺磁性、良好的生物相容性、低毒性诸多优点,受到了人们广泛而深入的研究。本文简要介绍了无机磁性粒子的制备方法和磁性聚合物微球的分类,主要对磁性高分子微球的传统制备方法和涌现新方法新技术进行了阐述,并分析了各种制备磁性聚合物微球方法的优缺点及主要影响因素。除此之外,本文也介绍了磁性聚合物微球近年来最新研究成果及应用领域,并对高分子微球未来发展趋势和存在的问题进行了分析。  相似文献   

5.
磁性高分子微球用于固定化酶的研究进展   总被引:22,自引:0,他引:22  
磁性高分子微球是近20年来发展起来的一种新型功能高分子材料,并已在生物化工、细胞学、生物医学工程等领域得到了广泛应用.本文主要介绍磁性高分子微球的制备和性质以及在固定化酶中的应用.  相似文献   

6.
磁性微球的制备及研究进展   总被引:13,自引:0,他引:13  
磁性微球作为一种新型功能材料,在磁性材料、生物工程等领域有着广泛的应用前景。文章对磁性高分子微球的制备方法、性质作了较详细的综述,着重介绍了磁性微球在细胞分离、蛋白质的提纯、固定化酶、靶向给药及核酸的分离等领域的应用。  相似文献   

7.
磁性高分子微球是近20年来发展起来的一种新型功能高分子材料,并已在生物化工、细胞学、生物医学工程等领域得到了广泛应用。本文主要介绍磁性高分子微球的制备和性质以及在固定化酶中的应用。  相似文献   

8.
磁性高分子微球是近20年来发展起来的一种新型功能高分子材料,并已在生物化工、细胞学、生物医学工程等领域得到了广泛应用。本文主要介绍磁性高分子微球的制备和性质以及在固定化酶中的应用。  相似文献   

9.
超顺磁性高分子微球的制备与表征   总被引:18,自引:2,他引:18  
用化学共沉淀方法制备了Fe3O4纳米微粒,并用油酸(十八烯酸)和十二烷基苯磺酸钠为双层表面活性剂进行表面修饰,制备了稳定的水分散性纳米Fe3O4可聚合磁流体.在Fe3O4磁流体存在下,将苯乙烯与甲基丙烯酸通过乳液聚合方法制备了磁性高分子微球.透射电镜研究表明,Fe3O4微粒的平均粒径在10nm左右,乳液聚合形成的磁性高分子微球的粒径平均约为130nm;用超导量子干涉仪对微粒及高分子微球进行了磁性表征,结果表明,合成的Fe3O4纳米微粒以及磁性高分子微球均具有超顺磁性.同时,还用红外光谱及X射线衍射表征了磁性高分子微球的化学成分和晶体结构.用热失重方法测得磁性高分子微球中磁性物质的含量为23.6%.  相似文献   

10.
生物高分子磁性微球作为性能优异的功能高分子材料在固定化酶、靶向药物、细胞分离和免疫分析等方面显示出强大的生命力。我们曾用凝胶-微乳液法化学剪裁技术制备了明胶包裹的复合磁性微粒,本文用共沉淀法制备磁性Fe3O4微晶作为磁性内核,明胶为包裹材料,  相似文献   

11.
A method for the synthesis of polymer magnetic microspheres which allows the production of magnetic labels with a high magnetic susceptibility was developed. The microspheres contain surface functional groups for immobilization of bioligands and meet the requirements for immunomagnetometric assay. The obtained polymer magnetic microspheres were subject to comparative tests with commercial magnetic latexes.  相似文献   

12.
Narrow-disperse magnetic microspheres were prepared by alkaline coprecipitation of Fe2+ and Fe3+ ions within poly(acrylic acid–divinylbenzene) microspheres that were prepared by distillation–precipitation copolymerization. Magnetic microspheres with polymer brushes that contain epoxy groups were prepared by graft copolymerization of glycidyl methacrylate and glycerol monomethacrylate via atom transfer radical polymerization (ATRP) from the magnetic microsphere surfaces. Subsequently, magnetic microspheres with thiol-containing polymer brushes were prepared by treating the epoxy group-containing magnetic microspheres with sodium hydrosulfide. Gold nanoparticles were immobilized in the brush layer of the thiol-containing magnetic microspheres through Au–S coordination. The catalytic activity of the gold nanoparticle-immobilized magnetic microspheres was investigated using the reduction of 4-nitrophenol to 4-aminophenol with sodium borohydride as a model reaction. The catalyst could be reused for over 10 cycles without noticeable loss of catalytic activity.  相似文献   

13.
徐潇  蒋姗  王秀瑜  姚立 《化学通报》2019,82(8):754-757
具有不同形貌的聚合物微球在生物和材料等领域应用广泛。目前,越来越多的研究选择以微流控技术为平台来制备聚合物微球。在这里,本文介绍了一种基于微流控技术,通过调节表面活性剂的HLB值从而制备具有拓扑结构磁性聚合物微球的方法。结果表明,不同表面活性剂的HLB值能够调控液滴的演变行为和目标微球的形貌特征。同时,该方法具备一定的普适性。这可作为制备聚合物微球的有效补充工具。  相似文献   

14.
孙爱娟  高礼 《化学研究》2011,22(1):61-65
采用改进的悬浮聚合法合成了一系列粒径和结构可调的羰基铁粉/聚苯乙烯磁性高分子微球.利用傅立叶变换红外光谱仪、热重分析仪、X射线衍射仪、扫描电镜等分析了微球的结构、化学成分及形貌.结果表明,通过改变苯乙烯单体和聚乙烯醇(PVA)的加入量,可以制备三类不同形貌和结构的复合微球,即多孔复合微球,无孔复合微球和含"带状"突起的...  相似文献   

15.
Hollow porous magnetic microspheres with strong magnetization and controllable structure were prepared via a facile electrostatic self-assembly of the positively charged Fe(3)O(4) nanoparticles onto the surface of the negatively charged poly(N,N'-methylenebisacrylamide-co-methacrylic acid) (P(MBAAm-co-MAA)) microspheres with subsequent removal of the polymer core through calcination at high temperature. The shell thickness was facilely tuned through the ratio between Fe(3)O(4) and polymer, and the void space was conveniently changed through the size of polymer microspheres. The hollow magnetic microspheres possessed high saturation magnetization value (51.38 emu/g) and porous structure with high specific surface area (108.04 m(2)/g). Based on these properties, the drug loading and release behaviors were investigated, which indicated that the hollow magnetic microspheres exhibited a controlled release process.  相似文献   

16.
分散聚合研究   总被引:15,自引:0,他引:15  
介绍了分散聚合制备聚合物微球的研究进展,对分散聚合的成核与稳定机理、聚合过程、动力学、反应参数对聚合物微球粒径及分散性的影响以及运用分散聚合制备功能性聚合物微球及聚合物--磁性材料复合微球的研究现状进行了回顾。  相似文献   

17.
磁微球及其在生化分离分析中的应用   总被引:8,自引:0,他引:8  
景晓燕  李茹民  王鹏  王君  袁艺  朱果逸 《分析化学》1999,27(12):1462-1467
磁微球是以金属或金属氧化物为核,外面包被带有活性基团物质的一种新型生物分离材料。目前制备磁微球的方法有包埋法、聚合法、浸渍法、挤压法和生物合成法等。这种微球通过其活性基团与化学、生化和生物物质连接后,利用其顺磁性外加一定磁场可实现与介质分离。本文全面地介绍了磁微球的制备,详尽评述了其在免疫分析、核酸杂交分析、基因测序、细胞分离、酶的固定、受体分离等各个领域的应用。  相似文献   

18.
A new approach, combining metal coordination with the molecular imprinting technique, was developed to prepare affinity materials. Magnetic poly(glycidyl methacrylate) microspheres in monosize form were used for specific recognition toward the target protein. The magnetic poly(glycidyl methacrylate) microspheres were prepared by dispersion polymerization in the presence of magnetite nanopowder. Surface imprinted magnetic poly(glycidyl methacrylate) microspheres based on metal coordination were prepared and used for the selective recognition of human serum albumin. Iminodiacetic acid was used as the metal coordinating agent and human serum albumin was anchored by Cu2+ ions on the surface of magnetic poly(glycidyl methacrylate) microspheres by metal coordination. The magnetic poly(glycidyl methacrylate) microspheres were coated with a polymer formed by condensation of tetraethyl orthosilicate and 3‐aminopropyltrimethoxysilane. The human serum albumin imprinted magnetic poly(glycidyl methacrylate) microspheres were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy and particle size analysis. The maximum adsorption capacity of human serum albumin imprinted magnetic poly(glycidyl methacrylate) microspheres was 37.7 mg/g polymer at pH 6.0. The selectivity experiments of human serum albumin imprinted magnetic poly(glycidyl methacrylate) microspheres prepared with different concentrations in the presence of lysozyme, bovine serum albumin and cytochrome C were performed in order to determine the relative selectivity coefficients.  相似文献   

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