共查询到18条相似文献,搜索用时 125 毫秒
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天然高分子材料研究进展 总被引:10,自引:0,他引:10
综述了近年来天然高分子材料的研究进展。主要介绍纤维素、木质素、淀粉、甲壳素、壳聚糖、其它多糖、蛋白质以及天然橡胶等天然高分子通过化学、物理方法以及纳米技术改性制备具有各种功能及生物可降解性环境友好材料的研究状况,并对此类新材料的应用前景进行了展望。 相似文献
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微球给药系统可实现药物的靶向给药,其在药物的缓控释放等方面表现出良好的应用前景,因而成为近年来药剂学领域的研究热点之一。高分子载体材料(Polymer Carriers)是随着药物学研究、生物材料科学和临床医学的发展而新兴起来的,是一类具有优良生物相容性、生物可降解性、可加工性,经过安全性评价并应用于药物制剂的高分子辅... 相似文献
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甲壳素和壳聚糖作为天然生物高分子材料的研究进展 总被引:9,自引:0,他引:9
甲壳素是自然界中含量仅次于纤维素的天然高分子,壳聚糖是甲壳素脱乙酰化后带有阳离子的多糖.壳聚糖中的自由氨基以及它的高结晶性,使得它能溶于酸,而不溶于碱和绝大数的有机溶剂.同时壳聚糖具有无毒性、无刺激性、良好的生物相容性、生物可溶解性, 以及高的电荷密度,因而被作为一种新型的天然生物材料得到广泛应用.文章介绍了甲壳素和壳聚糖的结构和性质,综述分析了甲壳素和壳聚糖在制备微球和作为支架材料中的应用, 并总结了甲壳素和壳聚糖在这两个方面存在的问题和发展前景. 相似文献
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综述了国内外应用生物多糖进行医用高分子材料表面修饰的研究状况,其中重点介绍了葡聚糖、肝素及类肝素类物质、壳聚糖等多糖在高分子材料表面修饰的研究近况.多糖是自然界中含量最为丰富的生物大分子,几乎存在于所有的生命体中,具有很好的生物相容性,而且某些生物多糖还具有特殊的生物活性,因此用生物多糖进行医用高分子材料的表面修饰受到了国内外研究学者的关注.大量研究表明,经过生物多糖表面修饰的高分子材料可获得良好的生物相容性和某些优良的医学应用性能. 相似文献
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《Arabian Journal of Chemistry》2020,13(12):8935-8964
This review depicts the exposure of chitin and chitosan base multifunctional nanomaterial composites for promising applications in field of biomedical science structure, synthesis as well as potential application from a colossal angle. We elaborated critically each of the chitin and chitosan base nanomaterial with its potential application toward biomedical science. For different biomedical applications it use in form of hydrogels, microsphere, nanoparticles, aerogels, microsphere and in form of scaffold. Due to this it had been blended with different polymer such as starch, cellulose, alginate, lipid, hyaluronic acid, polyvinyl alcohol and caboxymethyl cellulose. In this review article, a comprehensive overview of combination of chitin and chitosan base nanomaterial with natural as well as synthetic polymers and their biomedical applications in biomedical field involving drug delivery system all the technical scientific issues have been addressed; highlighting the recent advancements. 相似文献
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《高分子科学杂志,C辑:聚合物评论》2013,53(3):307-354
ABSTRACT Chitin and chitosan are versatile polymers, where the interest in chitosan is due to the large variety of useful forms that are commercially available or can be made available. Chitin basically is obtained from prawn/crab shells; chemical treatment of chitin produces chitosan. This article surveys applications of chitin and chitosan in various industrial and biomedical fields. 相似文献
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Bioartificial liver support system (BALS) has the potential to provide temporary support for patients with fulminant hepatic failure and consist of viable hepatocytes and scaffolding materials for hepatocytes attachment. Various scaffolding materials are used in BALS, including chitosan,which is easily obtained by deacetylation of chitin and widely applied in biomedical applications. In this paper, we introduce and discuses chitosan-based biomaterials for BALS application. 相似文献
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BAO Zhiming PAN Jilun LI Li YU Yaoting The Key Laboratory of Bioactive Materials Ministry of Education Nankai University Tianjin China 《Chinese Journal of Reactive Polymers》2006,(1)
1. INTRODUCTIONOrthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure [1]. A limitation of this therapy is a shortage of donor organs available. This donor organ shortage is exacerbated by the fa… 相似文献
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Tuyishime Philibert Byong H. Lee Nsanzabera Fabien 《Applied biochemistry and biotechnology》2017,181(4):1314-1337
The natural biopolymer chitin and its deacetylated product chitosan are found abundantly in nature as structural building blocks and are used in all sectors of human activities like materials science, nutrition, health care, and energy. Far from being fully recognized, these polymers are able to open opportunities for completely novel applications due to their exceptional properties which an economic value is intrinsically entrapped. On a commercial scale, chitosan is mainly obtained from crustacean shells rather than from the fungal and insect sources. Significant efforts have been devoted to commercialize chitosan extracted from fungal and insect sources to completely replace crustacean-derived chitosan. However, the traditional chitin extraction processes are laden with many disadvantages. The present review discusses the potential bioextraction of chitosan from fungal, insect, and crustacean as well as its superior physico-chemical properties. The different aspects of fungal, insects, and crustacean chitosan extraction methods and various parameters having an effect on the yield of chitin and chitosan are discussed in detail. In addition, this review also deals with essential attributes of chitosan for high value-added applications in different fields and highlighted new perspectives on the production of chitin and deacetylated chitosan from different sources with the concomitant reduction of the environmental impact. 相似文献
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S. Sh. Rashidova R. Yu. Milusheva N. L. Voropaeva S. R. Pulatova G. V. Nikonovich I. N. Ruban 《Chromatographia》2004,59(11-12):783-786
At the Institute of Polymer Chemistry and Physics we have investigated the isolation of chitin from a variety of raw materials—of Aral Sea crustaceans, the basidial fungus Pleurotus ostreatus, and waste from production of natural silk from the chrysalis of the silkworm Bombyx mori. The silk worm chrysalis, waste material from silk production, is a very valuable and readily available source of chitin, although new technology must be developed to enable use of the waste. Other raw materials suitable for isolation of chitin are also being investigated. Other subjects of interest are modification of chitin, preparation of chitosan from it, and interaction of these materials with transition metals ions, because water-soluble polymer–metal complexes of known metal-ion content have medical and agricultural applications. Formation of complexes between chitosan and transition metal ions (Co, Ni, Cu, Mn) has been investigated. Differences between the spectra of chitosan and its metal complexes are all in the region of the stretching and deformation vibrations of the amide bonds (amide-I, amide-II, and amide-III). This is because the synthesis of chitosan–metal complexes was conducted in acid media, in which the chitosan amino group is protonated, so the preferred interaction takes place with the amide bond of chitosan. Noticeable changes of amide-I and amide-II intensities are observed, depending on the metal ion content; this changes can be used for estimation of the metal content in the samples. It has been shown that in the samples synthesized the metal ions are distributed fairly uniformly along the polymer chains. The composition and structures of the complexes formed, the conditions needed to include the different functional groups of the polymer in the coordination process, and the dynamics of macromolecular tangling behavior in the process of metal-ion binding were determined. This enables prediction of the behavior of chitosan–metal-ion systems under conditions of use. 相似文献
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尿素能够显著破坏甲壳素/壳聚糖分子氢键结构和疏水相互作用,增加其临界胶束浓度,促进多糖大分子的溶解,并能减少其在溶液中的自聚集现象.碱-尿素水溶液可以作为一种新型的甲壳素/壳聚糖绿色溶剂,有望用于对刺激性要求较为苛刻的食品、生物医学等领域.壳聚糖衍生物特别是其与过渡金属离子的配合物具有良好的尿素吸附功能,可用于尿毒症患者血液中小分子毒物的吸附,对机体刺激性小且不吸附血清蛋白等生物大分子.有望成为血液灌流治疗法中清除尿素等小分子毒性物质的良好吸附剂.壳聚糖还可以作为包膜材料,制备壳聚糖包膜尿素,与普通的包膜尿素相比性能更为优越. 相似文献