含苯并三唑色酮及1,3,4-噁二唑啉类化合物的合成

研究了一种简便的合成2位含氮杂环色酮类化合物的方法。1H-苯并三唑与ClCH~2COOH反应制得1H-苯并三唑-1-乙酸(1),以此为原料合成了一系列2位含1H-苯并三唑-1-甲基色酮(5)和相关的1,3,4-噁二唑衍生物(8)。     

1H-苯并三唑-1-乙酸稀土配合物的合成、表征及性质

溶液法合成了铕、铽与1H-苯并三唑-1-乙酸及1,10-邻菲啰啉的稀土配合物。通过元素分析、稀土配位滴定、摩尔电导、红外光谱、紫外光谱等手段对配合物进行了表征。结果表明,配合物的可能组成为Ln(L)3phen(Ln=Eu(III),Tb(III);HL=1H-苯并三唑-1-乙酸,Hbtaa;phen=1,10-邻菲啰啉)。利用荧光光谱、热分析和电化学方法讨论了配合物性质。荧光光谱表明配合物均有较好的发光性能。     

稀土与水杨醛-1H-苯并三唑乙酰腙配合物的合成及抑菌实验

SBTH;生物活性;稀土与水杨醛-1H-苯并三唑乙酰腙配合物的合成及抑菌实验     

两个新的氮杂环基氢硼酸根及其金属配合物的研究

以硼氢化钾、咪唑、苯并三唑为原料,合成了一氢三(1-咪唑基)硼酸钾和二氢双(1-苯并三唑基)硼酸钾,并以它们为配体合成了一些金属配合物。     

3,4-二氢-1H-2-苯并吡喃衍生物化合成

3,4-二氢-1 H-2-苯并吡喃也俗称异色满(isochroman)。近年来,将该类化合物引入到药物合成中的研兖引起了人们的兴趣。虽然,已经合成出许多具有镇痛、降血压、抗组胺。和抗肿瘤等药理活性的3,4-二氢-1 H-2-苯并吡喃类化物,合但大都为异色满环上的1,3,4位取代衍生物或者螺环化合物,关于并杂环合成方面的研究至今不多见,作者前     

2H-苯骈吡喃类化合物的简便合成方法

2 H-苯骈吡喃(2 H-1-benzopyranes,1)又称色烯(chrom-3-ene),是一类天然有机化合物的基本骨架。许多包烯类化合物具有生物活性和光致变色效应,因此它们的合成方法一直是合成化学家感兴趣的课题。本文报道一种简便合成2 H-苯骈吡喃基本骨架的新方法,并用此法合成了从 Ageratum 属植物中分离得到的2,2-二甲基-6,7-二甲氧基苯骈吡喃(2)。     

通过Heck反应合成3-(2-羧基乙基)-1H-吡咯[2,3-b]吡啶-2-甲酸

以1H-吡咯[2,3-b]吡啶-2-甲酸乙酯为起始原料,经5步反应合成了新化合物3-(2-羧基乙基)-1H-吡咯[2,3-b]吡啶-2-甲酸,其结构经1H NMR和HR-MS表征。合成中间(E)-1-Ts-3-(3-乙氧基-3-氧代丙基-1-烯基)-1H-吡咯[2,3-b]吡啶-2-羧酸乙酯的最佳反应(Heck)条件为:无水DMF为溶剂,Pd(OAc)2为催化剂,dppf为配体,三乙胺为碱,收率88%。     

咪唑/三唑羧酸配体配合物的合成及性能研究

本文以含咪唑/三唑基的两种有机羧酸H2L1和H2L2(H2L1=2-(4-(1H-1,2,4-三唑-1-基)苯基)-1H-苯并[d]咪唑-5-羧酸;H2L2=2-(4-(1H-咪唑-1-基)苯基)-1H-苯并[d]咪唑-5-羧酸)为配体,在溶剂热条件下合成三种新的金属配合物[Co(HL1)2(H2O)4] (1),[N...     

苯甲酰苯并咪唑衍生物的合成

以3,5-二甲基-1H-吡咯-2-甲酸乙酯(2)为起始原料,与新型Vilsmeier试剂反应得4-甲酰基-3,5-二甲基-1H-吡咯-2-甲酸乙酯(3);3与3,4-二氨基二苯甲酮环合制得4-(5-苯甲酰-1H-苯并咪唑-2-基)-3,5-二甲基-1H-吡咯-2-甲酸乙酯(4);4水解后与2-吡唑啉经脱水反应合成了一个苯并咪唑衍生物,总收率54%,其结构经1H NMR,13C NMR和MS确证。     

5-甲基苯并三唑-1-乙酸铕三元配合物的合成及表征

以5-甲基-苯并三唑-1-乙酸和1,10-邻菲啰啉为配体,采用溶液法合成了一种铕配合物。通过元素分析、配位滴定、摩尔电导率、红外光谱和紫外光谱对其进行表征。其组成可能为Eu(L)3phen·3.5H2O(HL=5-甲基-苯并三唑-1-乙酸,5-mbtaa;phen=1,10-邻菲啰啉)。使用热分析和荧光光谱研究了配合物的性质。热分析结果显示:铕配合物具有较好的热稳定性。荧光光谱显示:该配合物发出Eu(Ⅲ)特征荧光,并且5-甲基-苯并三唑-1-乙酸是较好的敏化剂。     

Hypervalent Iodine‐Mediated Selective Oxidative Functionalization of (Thio)chromones with Alkanes

C?C bond formation is the most fundamental way for the chain propagation in organic molecules. This achievement through tandem oxidation of two different C?H bonds represents the state of the art in organic synthesis. Selective functionalization of the ubiquitous aliphatic C?H bonds offers an attractive option for this oxidative cross‐coupling methodology. To develop such a methodology under mild and “metal‐free” conditions remains challenging. Herein, we report hypervalent iodine‐mediated selective oxidative functionalization of aliphatic C?H bonds of alkanes with chromones and (thio)chromones. A wide range of alkanes, both cyclic and acyclic, has been found to react selectively and predictably in good yields. The developed methodology is also the first report of a direct oxidative functionalization of the C‐2 position of (thio)chromones with alkanes to access bioactive compounds.     

3-(2-二唑啉基)-色酮类化合物的合成研究

报道了取代的邻羟基苯乙酮(1a～1e)经Vilsmeier-Haack反应一步制得3-醛基色酮(2a～2e),2a～2e与取代的芳酰肼(3a～3c)缩合制得15个酰腙类化合物(4a～4o),4a～4o在醋酸酐作用下关环得15个3-(2-苝二唑啉基)-色酮(5a～5o),并通过元素分析,IR,~1H NMR和MS诺数据确证了上述化合物的结构。     

3-(2-卓二唑啉基) - 色酮类化合物的合成研究

报道了取代的邻羟基苯乙酮(1a～1e)经Vilsmeier-Haack反应一步制得3－醛基色酮(2a～2e),2a～2e与取代的芳酰肼(3a～3c)缩合制得15个酰腙类化合物(4a～4o),4a～4o在醋酸酐作用下关环得15个3-(2-卓二唑啉基)-色酮(5a～5o),并通过元素分析,IR,^1^HNMR和MS谱数据确证了上述化合物的结构。     

3-（3-乙酰基-5-芳氧亚甲基-2,3-二氢-1,3,4-噁二唑-2-基）色酮类化合物的合成

3-（3-乙酰基-5-芳氧亚甲基-2;3-二氢-1;3;4-噁二唑-2-基）色酮类化合物的合成;噁二唑啉;色酮;合成     

Chemistry of the heteroanalogs of isoflavones. 20. Benzimidazole analogs of isoflavones

3-(2-Benzimidazolyl)chromones with electron-donating and electron-withdrawing substituents and also chromones unsubstituted at position 2 were obtained by the reaction of alkyl--(2-benzimidazolyl)-2,4-dihydroxy-5-acetophenones with carboxylic acid anhydrides and chlorides. Reactions with cleavage and with retention of the pyrone ring were carried out.For Communication 19, see [1].Taras Shevchenko Kiev University, Kiev. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1237–1244, September, 1997.     

Synthesis and properties of photosensitive compounds based on bromine-containing 3-acyl-2-furylchromones

Methods have been developed for the synthesis of new photosensitive compounds based on the reaction of N,S,O-nucleophiles with 3-acyl-2-(5-bromofur-2-yl)chromones and 3-acyl-2-(5-bromomethylfur-2-yl)chromones. The relationship between the spectral properties and the structure of compounds has been shown.     

Synthesis of 2‐Dihydrooxadiazolinyl Chromones

Reactions of the substituted 2‐formyl chromones with aroylhydrazines gave corresponding 2‐(aroylhydrazonomethylidyne) chromones. Then 2‐(3′‐acetyl‐5′‐aryl‐2′,3′‐dihydro‐1′,3′,4′‐oxadiazol‐2′‐yl) chromones were prepared by these 2‐(aroylhydrazonomethylidyne) chromones under refluxing with Ac₂O. All target compounds were characterized through elemental analysis and IR, ¹H NMR, MS.     

Microwave-assisted synthesis of functionalized flavones and chromones

A facile microwave synthesis of functionalized flavones and chromones via the cyclization of 1-(2-hydroxyaryl)-3-aryl-1,3-propanedione is described.     

Synthesis of 6-(2-hydroxyaryl)-2-pyridones by the reaction of chromones with cyanoacetic,acetoacetic, and malonic acid amides

A reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides in the presence of sodium ethoxide furnished a number of new 3-substituted 6-(2-hydroxyaryl)-2-pyridones in good yields, including those containing a polyfluoroalkyl group at position 4.