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1.
以D-木糖及D-葡萄糖为原料, 经具有降冰片结构的双环缩醛中间体, 合成了适当羟基保护的五元环氮杂糖衍生物及其氟代衍生物, 进一步探讨了含氮杂糖结构的双糖衍生物的合成.  相似文献   

2.
噻吩并嘧啶酮衍生物是一类具有良好生物活性的稠杂环化合物.文献中已报道了多种这类杂环的合成方法,然而2-氨基取代的噻吩并嘧啶酮衍生物却缺乏有效的制备方法.最近,氮杂Wittig反应广泛地应用于氮杂环的合成,该反应原料易得、条件温和、反应选择性好,已成为一种合成氮杂环的有效手段.我们曾报道应用氮杂Wittig反应合成咪唑啉酮和喹唑啉酮杂环的新方法,这里进一步报道应用该法合成噻吩并嘧啶酮杂环.  相似文献   

3.
李智  谭成权 《合成化学》2000,8(3):197-201
综述了以氮杂二烯为原料,光化学反应合成喹啉衍生物的最新进展.参考文献18篇.  相似文献   

4.
3-杂环基硫取代-1,3,4,5-四氢-2-氧代-苯并氮杂衍生物的合成   总被引:1,自引:0,他引:1  
以芳酰肼为原料,合成了一系列3-巯基-5-芳基-1,2,4-三唑、2-巯基-5-芳基-1,3,4-噁二唑和2-巯基-5-芳基-1,3,4-噻二唑,并通过硫原子对3-溴-2-氧代-苯并氮杂3-位上的亲核取代反应将杂环化合物引入了苯并氮杂的结构当中,合成了32个新的苯并氮杂杂环衍生物.为提高其在有机溶剂中的溶解性,在苯并氮杂的N原子上引入乙酸乙酯和乙酸叔丁酯基取代基,合成了36个新衍生物.所有化合物经质谱、核磁共振谱及元素分析确证了结构并初步测定了抗菌活性.  相似文献   

5.
苯并[b][1,4]二氮杂衍生物是一类含有两个氮杂原子的苯并七元杂环化合物,以其特殊的结构特点和广泛的生理及药理活性而备受关注,因此其合成和活性研究也是有机化学及药学领域的研究热点.就近10年来苯并[b][1,4]二氮杂衍生物在抑菌、抗神经炎和抗癌活性等方面的应用进展进行了归纳总结;综述了其不同催化体系下合成及机理的最新研究进展,同时对本课题组的研究成果做了阐述,并对其合成及应用前景进行了展望.  相似文献   

6.
以芳酰肼为原料, 合成了一系列3-巯基-5-芳基-1,2,4-三唑、2-巯基-5-芳基-1,3,4-噁二唑和2-巯基-5-芳 基-1,3,4-噻二唑, 并通过硫原子对3-溴-2-氧代-苯并氮杂3-位上的亲核取代反应将杂环化合物引入了苯并氮杂的结构当中, 合成了32个新的苯并氮杂杂环衍生物. 为提高其在有机溶剂中的溶解性, 在苯并氮杂的N原子上引入乙酸乙酯和乙酸叔丁酯基取代基, 合成了36个新衍生物. 所有化合物经质谱、核磁共振谱及元素分析确证了结构并初步测定了抗菌活性.  相似文献   

7.
本文通过N-取代芳磺酰胺和N,N′-环氮甲基亚胺发生[4+3]环加成反应,得到了一种高效合成三环苯并三氮杂■衍生物的方法。对该反应的条件如溶剂和碱进行了筛选,在最优条件下,考察了底物普适性,并合成了9个苯并三氮杂■衍生物,收率为36~99%。所有目标化合物通过~1H NMR、~(13)C NMR和HRMS进行了结构确证。  相似文献   

8.
硫杂杯[4]二醛基衍生物(1)在水合肼中肼解,合成了新化合物硫杂杯[4]二醛腙基衍生物(2);1和2在弱酸的催化下反应合成了新的具有对称结构的苄连氮双硫杂杯[4]芳烃(3);2和3的结构经1H NMR,IR,ESI-MS和元素分析表征.  相似文献   

9.
通过1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷与酸反应或1-(3-氯丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷与胺反应,合成了14种1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物.体外细胞培养试验结果表明,某些1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物对艾氏腹水癌细胞具有较好的杀伤活性.  相似文献   

10.
异伍兹烷衍生物的研究进展   总被引:5,自引:0,他引:5  
六硝基六氮杂异伍兹烷(HNIW或CL-20)是当今世界上综合性能最好的单质炸药,在20余年的研究过程中,各国研究者合成出了百余种异伍兹烷衍生物.根据笼体上取代基的不同以及合成反应的类型,系统总结了各类衍生物的合成、用途及反应性.最后对异伍兹烷衍生物的发展方向进行了展望.  相似文献   

11.
双羰基侧链取代喹喔啉-1,4-二氧化物的合成   总被引:1,自引:0,他引:1  
应用改良的Beirut反应合成了5个双羰基侧链取代喹喔啉-1,4-二氧化物(3a~3e)。  相似文献   

12.
《Mendeleev Communications》2022,32(6):789-791
Perfluoro-cyclo-tetrakis(1,4-phenylene sulfide) has been synthesized by the reaction of tetrafluorobenzene-1,4-dithiol with perfluoro-1,4-bis(phenylthio)benzene. The reaction of tetrafluorobenzene-1,4-dithiol with perfluoro-m-xylene gives a macrocycle with 1,3- and 1,4-arrangement of bridged sulfur atoms.  相似文献   

13.
Simons electrochemical fluorination (ECF) of 1,4-dimethyl-1,4-homopiperazine, methyl 4-ethylhomopiperazin-1-ylacetate and 1,4-bis(methoxycarbonylmethyl)-1,4-homopiperazine was studied. For comparison, ECF of three piperazines with a N-(methoxycarbonylmethyl) group(s) was also studied. ECF of 1,4-dimethyl-1,4-homopiperazine gave a low yield of corresponding perfluoro(1,4-dimethyl-1,4-homopiperazine) together with perfluoro(2,6-diaza-2,6-dimethylheptane) as the major product. Corresponding perfluoro(homopiperazines) with mono- and/or di-(fluorocarbonyldifluoromethyl) groups [CF2C(O)F] at the 1- and/or 4-position were formed in low yields from methyl 4-ethylhomopiperazin-1-ylacetate and 1,4-bis(methoxycarbonylmethyl)-1,4-homopiperazine, respectively. These new seven-membered perfluoro(1,4-dialkyl-1,4-homopiperazines) were accompanied by the formation of mono- and/or di-basic linear perfluoroacid fluorides resulting from the CC bond scission at the 2- and 3-positions of the ring. From mono- and/or di-N-(methoxycarbonylmethyl)-substituted piperazines, corresponding perfluoropeperazines having the acid fluoride group(s) were formed in low yields.  相似文献   

14.
3-Hydroxy-2,3-dihydropyrazine 1,4-dioxide derivatives were obtained by condensation of 2-hydroxyamino-2-methylpropanal oxime with glyoxal, diacetyl, and 1,2-cyclohexanedione in water, and 3-methoxy-2,3-dihydropyrazine 1,4-dioxide was obtained by condensation with diacetyl in methanol. 2,5-Dihydropyrazine 1,4-dioxide is formed when 2-hydroxyamino-2-methylpropanal oxime is heated in a solution of acetone and dilute hydrochloridic acid. The reduction of 3-hydroxy- and 3-methoxy-2,3-dihydropyrazine 1,4-dioxides and 2,5-dihydropyrazine 1,4-dioxide leads to 1,4-dihydroxypiperazines, and the bromination of 3-methoxy-2,3-dihydropyrazine 1,4-dioxide gives 5,6-bis(bromomethyl)-3-methoxy-2,3-dihydropyrazine 1,4-dioxide. 1,4-Dihydroxy-2,5-piperazinedione was obtained by oxidation of 2,5-dihydropyrazine 1,4-dioxide.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1414–1418, October, 1983.  相似文献   

15.
Fenton试剂是某些烃类化合物的有效氧化剂^[1],该体系对芳香化合物具有羟化作用。我们^[2]曾报道了含Cu类钙钛石型复合氧化物在苯酚烃化反应中的催化活性,并提出了相应的反应机理。高价态的过渡金属离子如C^3 [2]和Fe^3 [3]通常被认为是中间自由基的氧化剂。实际上,醌类化合物及其还原形式半醌、氢醌与生物体内许多电子转移过程密切相关^[4],如泛醌或辅酶Q在生物体呼吸链电子传递过程中起重要作用^[5]。在实验中我们观察到苯酚羟化反应中不仅有苯醌生成,而且生成的苯醌还能促进羟化反应。本文报道了醌类化合物在苯酚羟化循环中的传递电子作用。  相似文献   

16.
4-Fluorobenzophenone reacted with potassium carbonate in the presence of silica catalyst in diphenyl sulfone solvent to yield 4,4′-dibenzoyldiphenyl ether. This new etherification reaction was extended to three difluoro aromatic ketones. 4,4′-Bis(4-fluorobenzoyl)diphenyl ether ( I ) reacted with potassium carbonate to yield a crystalline poly(oxy-1,4-phenylene-carbonyl-1,4-phenylene) (PEK) and 4,4′-bis{4-[4-(4-fluorobenzoyl)phenoxy]benzoyl}benzene ( II ) gave a crystalline poly(oxy-1,4-phenylene-carbonyl-1,4-phenylene-oxy-1,4-phenylene-carbonyl-1,4-phenylene-oxy-1,4-phenylene-carbonyl-1,4-phenylene-carbonyl-1,4-phenylene)(PEKEKEKK). 2,8-Bis(4-fluorobenzoyl)dibenzofuran ( III ) or 2,8-bis(4-chlorobenzoyl)dibenzofuran ( IV ) reacted with potassium carbonate to yield a poly(oxy-1,4-phenylene-carbonyl-2,8-dibenzofuran-carbonyl-1,4-phenylene) (PEKBK). The PEKBK was a noval amorphous polymer with the glass transition temperature of 222°C and it showed excellent thermal stability [T. Tanabe and I. Fukawa, Jpn. Pat., Kokai 64–74223 (1989)]. Several amorphous dibenzofuran type polyetherketone copolymers were prepared by coplycondensation of III with 4,4′-difluorobenzophenone ( V ) or 1,4-bis(4-fluorobenzoyl)benzene ( VI ) [T. Tanabe and I. Fukawa, Jpn. Pat., Kokai 1153722 (1989)]. © 1992 John Wiley & Sons, Inc.  相似文献   

17.
To establish factors that determine the formation of three-dimensional hybrid structures of metal dicarboxylates involving metal-oxygen-metal linkages, we have investigated metal dicarboxylates derived from 1,2-cyclohexene as well as 1,2-, 1,3-, and 1,4-cyclohexane dicarboxylic acids. Thus, we have synthesized a 1,2-cyclohexenedicarboxylate of Cd, [Cd(1,2-CHeDC)(H2O)] (I), a 1,2-cyclohexanedicarboxylate of Pb, [Pb(1,2-CHDC)] (II), and three 1,4-cyclohexanedicarboxylates of La [La2(1,4-CHDC)3(H2O)4] (III), [La3(1,4-HCHDC)2(1,4-CHDC)5(H2O)2].H2O (IV) and [La2(1,4-CHDC)3(H2O)].2.5 H2O (V) under hydrothermal conditions and determined their structures. A mixed dicarboxylate involving both 1,3- and 1,4-cyclohexenedicarboxylates of Pb, [Pb3O(1,3-CHDC)(1,4-CHDC)].0.5 H2O (VI) and a 1,4-cyclohexanedicarboxylate of Pb, [Pb(6)O(2)(1,4-CHDC)3(1,4-HCHDC)2], have also been synthesized and characterized. While the 1,2-dicarboxylates have layered structures, the 1,4-dicarboxylates and the mixed dicarboxylates possess three-dimensional structures. Interestingly, both the 1,2 and 1,4-dicarboxylates are true hybrid compounds composed of infinite M-O-M linkages. The equatorial-equatorial (e,e) conformation is adopted commonly in all these compounds, although less stable conformations are encountered occasionally. The formation of the layered and the three-dimensional structures can be understood based on the relative disposition of the two carboxylic groups, the 1,4-isomer favoring the three-dimensional structure. Based on the results of the present study along with the available literature, we conclude that in order to obtain three-dimensional hybrid structures with metal-oxygen-metal networks, it appears necessary to make use of the 1,4-cyclohexanedicarboxylic acid.  相似文献   

18.
A series of novel oligo(halobenzoquinoid) compounds have been obtained from the photoinduced self-substitution of 2,5-dibromo-1,4-benzoquinone (1a), 2,6-dibromo-1,4-benzoquinone (1b), 2-chloro-1,4-benzoquinone (1c), 2-bromo-5-chloro-1,4-benzoquinone (1d), 2,3,5,6-tetrachloro-1,4-benzoquinone (1e) and 1,4-benzoquinone (1f) in the presence of N,N-dimethyl-t-butylamine (2) in acetonitrile. Dimers, trimers and/or pentamers of these haloquinones were found to be the major products.  相似文献   

19.
The syntheses of 1,4-dideoxy-1,4-imino-D-lyxitol (3), 1,4-dideoxy-1,4-imino-d-arabinitol (4) and 1,4-dideoxy-1,4-imino-l-arabinitol (5) are reported; (3) is a potent competitive inhibitor of α-galactosidase (green coffee beans) and (4) a competitive inhibitor of α-glucosidase (Brewer's yeast) suggesting that iminopentitols have considerable potential as glycosidase inhibitors. (4) was found to be identical to an alkaloid recently isolated from Angylocalyx boutiqueanus.  相似文献   

20.
Aromatic nitrogen heterocycles, e.g. quinoline, 2,2‘-bipyridyl and 1,10-phenanthroline, are reduced in a uniquely specific and selective way by the bispyridine complexes of bis(1,4-dihyro-1-pyridyl)zinc and bis(1,4-dihydro-1-pyridyl)magnesium. The reactions occur by hydrogen transfer from the metal-bound 1,4-dihydropyridyl moieties to the substrates and yield zinc or magnesium salts of the 1,4-dihydroazaaromatic derivatives. Upon hydrolysis, the 1,4-dihydroazaaromatic compounds are liberated from the metal ions. The isolation and purification of several of the (novel) reduced compounds, e.g. 1,4-dihydroquinoline and 1,4-dihydro-1,10-phenanthroline, are described.  相似文献   

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