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1 引 言龙胆科 (Gentianacese)植物长梗喉毛花 (ComastomaPedunlulatum[RogleexD .Dou]Holub)分布在西藏、青海、甘肃和四川北部 ,生长在海拔 3 0 0 0~ 4 80 0m的河滩和高山草甸等环境中。《晶珠本草》记载 :植物长梗喉毛花比之加滴色淡而软 ,叶微黄。藏名“桑斗” ,藏医常用药。全草入药 ,性味苦寒 ,有利湿祛痰、清热解毒、舒肝利胆等功效。藏药长梗喉毛花富含酮类化合物 ,酮又称苯并色原酮。自然界得到酮是黄色的酚性化合物 ,它是有广泛的生理活性 ,具有解肝毒、护肝、抗炎… 相似文献
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洋地黄强心甙是一类重要的强心药物,大多是从紫花洋地黄(Digitalis purpurea)和毛花洋地黄(Digita(?)s lanata)二种植物中提取分离纯品,例如洋地黄毒甙(Digitoxin,Ⅰ)、异羟基洋地黄毒甙(Digoxin,Ⅱ)、羟基洋地黄毒甙(Gitoxin,Ⅲ)等。只有在碳-12位上有羟基的所谓 C-甙才有重要药用价值,但是在分离过程中大量混有碳-12位上没有羟基的所谓 A-甙, 相似文献
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本文报道在0.01M ICH_2COONH_4-0.2M NH_4Cl底液中,用单扫示波极谱测定地高辛、洋地黄毒甙和毛花强心丙等心血管药物。它们的还原峰电位顺次为-1.54,-1.53和-1.60V(vs.SCE)。峰电流与地高辛浓度在2.0—60ng/ml,洋地黄毒甙在5.0—400ng/ml,毛花强心丙在15—125ng/ml范围均有良好的线性关系。对25ng/ml地高辛测定12次的变动系数为1.74%。 相似文献
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五味子酯J和五内酯F的分离与结构 总被引:5,自引:0,他引:5
从长梗南五味子(Kadsura Lorgipedunculata Finet.et Gagnep)种子中分得2个新化合物: 五味子酯(schisantherin)J(1)和五内酯(schisanlactone)F(2); 4个已知物: 五内酯(Schisanlactone)A、schizandronic acid、表安五酸(epianwuweizic acid)和二甲基去当归酰五味子酯F, 抗癌药理筛选表明, 在体外2对白血病P-388细胞有明显抑制作用。 相似文献
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五内酯E和长南酸的分离与结构 总被引:10,自引:0,他引:10
从浙江临安产的长梗南五味子(Kadsura longipedunculata Finet. etGagnep.)根皮中分得2个新三萜化合物: 五内酯E(Schisanlactone E, 1)和长南酸(changnanic acid 2)以及3个已知物: 五内酯B(schisanlactone B,3)、meso-二氢愈创木脂酸(meso-dihydoguaiaretic acid,4)和β-谷甾醇(β-sitosterol,5)。1和2在体外对白血病p-388细胞有明显地抑制作用, IC50分别为1μg/mL和10μg/mL。本文报道其分离、鉴定与结构研究。 相似文献
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中药木瓜挥发油成分的GC-MS分析 总被引:2,自引:0,他引:2
木瓜为常用抗风湿药,现代药理及临床研究表明木瓜具有舒经活络和胃化湿的功用~([1]),为蔷薇科植物贴梗海棠的干燥近成熟果实(又称皱皮木瓜)~([2]).目前,中药木瓜的研究主要在性状、理化性质鉴别、药理作用等方面;而对所特有的挥发性成分研究较少.史亚歌等~([3])采用水蒸气蒸馏法提取光皮木瓜挥发油进行了GC-MS分析.本研究针对浙江产中药木瓜,以水蒸气蒸馏法提取挥发油,采用毛细管气相色谱-质谱联用进行分离和鉴定,为进一步阐明中药木瓜化学组成及合理开发利用木瓜资源提供参考. 相似文献
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我们曾从甘肃省漳县采集的长梗千里光全草中分离并鉴定出两个呋喃雅槛兰型倍半萜. 在此基础上, 本文对其脂溶性化学成分进行深入研究, 除了发现倍半萜外, 又分离并鉴定出2个呋喃雅槛兰型倍半萜. 通过IR, UV, MS, CD和NMR等数据分析, 确定了4个化合物的结构, 其中, 化合物3首次在长梗千里光中分离得到, 化合物4是一种新化合物, 通过圆二光谱及核磁共振和NOE差谱研究其立体化学结构, 并按Dreiding models构筑该化合物分子的立体化学结构, 确定该化合物为Non-steroid型构象. 相似文献
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利用手持技术改进测定乙醇分子结构实验 总被引:1,自引:0,他引:1
利用压强传感器代替排水集气法,改进测定乙醇分子结构实验的仪器装置,并探索最佳反应条件。另外,设计两个空白实验,结合压强变化曲线对实验误差进行相关讨论。 相似文献
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Mustafa R. Ibrahim Zacharia A. Fataftah Paul von Ragu Schleyer Peter D. Stout 《Journal of computational chemistry》1987,8(8):1131-1138
Sets of hydrogen molecule equivalents have been developed which permit the calculation of hydrogenation of different types of carbon-carbon bonds from ab initio total energies (3-21G and 6-31G* basis sets, and, to a more limited extent, for MP2/6-31G* data) of reactants and products. The calculated enthalpies of hydrogenation are in good agreement with experiment for unstrained molecules, with average errors on the order of 2 kcal/mol. The 6-31G* equivalents allow the enthalpies for strained molecules to be calculated accurately, but the 3-21G equivalents do not. The equivalents for both basis sets have been tested by calculating the enthalpies of hydrogenation of carbon-carbon bonds in nitrogen- and oxygen-containing organic molecules, free radicals, and classical carbocations. The results are in good agreement with experiment in most cases. 相似文献
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V. I. Bol'shakova L. I. Demenkova É. N. Shmidt V. A. Pentegova 《Chemistry of Natural Compounds》1988,24(6):691-694
The compositions of the neutral diterpenoids of the oleoresins of five species of conifers growing in the Transcarpathia have been studied. It has been found that the oleoresins ofAbies alba M.,Larix decidua M., andPicea excelsa L. contain more than 50% of neutral diterpenoids. The group and qualitative compositions of the oxygen-containing diterpenoids have been determined. In the oleoresins ofAbies alba,Picea excelsa, andPicea abies tertiary alcohols — cis-abienol and isocembrol — predominate, while inLarix decidua the main component is the hydroxy ester larixyl acetate. Primary alcohols related to the resin acids have been found in all the oleoresins investigated. Features of the distribution of diterpenoids according to the species of conifers have been revealed. The results obtained are necessary for the chemotaxonomy of conifers of the family Pinceae. 相似文献
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由于石化行业的生产需要,其材质的使用具有多样性和广泛性,经常会出现顾客委托的测试样品的一个或几个元素跨越光谱仪现有测试程序测量范围的情况。本法通过对光谱仪测试原理的认识,根据光谱仪的测试能力及标样的采集,实现了一个或几个元素测量范围的扩展,并对其测量的影响因素进行了研究。 相似文献
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V. I. Bol'shakova L. I. Demenkova É. N. Shmidt V. A. Pentegova 《Chemistry of Natural Compounds》1989,24(6):691-694
The compositions of the neutral diterpenoids of the oleoresins of five species of conifers growing in the Transcarpathia have been studied. It has been found that the oleoresins ofAbies alba M.,Larix decidua M., andPicea excelsa L. contain more than 50% of neutral diterpenoids. The group and qualitative compositions of the oxygen-containing diterpenoids have been determined. In the oleoresins ofAbies alba,Picea excelsa, andPicea abies tertiary alcohols — cis-abienol and isocembrol — predominate, while inLarix decidua the main component is the hydroxy ester larixyl acetate. Primary alcohols related to the resin acids have been found in all the oleoresins investigated. Features of the distribution of diterpenoids according to the species of conifers have been revealed. The results obtained are necessary for the chemotaxonomy of conifers of the family Pinceae.Novosibirsk Institute of Organic Chemistry, Siberian Branch, Academy of Sciences of the USSR. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 812–816, November–December, 1988. 相似文献
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Influence of viscosity of medium on processes of oxygen quenching of excited states of mesoporphyrin
E. I. Kapinus V. A. Ganzha B. M. Dzhagarov E. I. Sagun V. B. Pavlenko 《Theoretical and Experimental Chemistry》1989,25(2):146-151
The oxygen quenching rate constants for singlet and triplet excited states of the dimethyl ester of mesoporphyrin IX increase with decreasing viscosity of the medium and reach a maximum at a viscosity of approximately 0.4 mPa·sec, after which the rate constants begin to decrease. The drop in rate constant with increasing fluidity of the medium may be related to a nonequilibrium character of the elementary act in the interaction of the reactants in the solvent cage. In viscous media such as isopropyl alcohol, isobutyl alcohol, and isoamyl alcohol, the reaction radius is greater than the sum of the radii of the reacting particles. The long-range character of these processes is due to the relatively weak dependence of the quenching probability on distance.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 25, No. 2, pp. 161–167, March–April, 1989. 相似文献