体现工科特色的高分子化学教学探索与实践

"高分子化学"是华东理工大学高分子材料科学与工程、复合材料以及材料物理专业的核心专业课程,上海市精品课程.本文阐述了工科院校高分子化学课程教学的特色,关键问题和对策.同时结合作者的实践,探索了体现工科特色的高分子化学教学方法、教学手段和教学技巧.     

福州大学化学一流专业建设的探索与成效

福州大学化学专业是由著名化学家卢嘉锡先生于1958年创建的。经过多年的探索与实践,在一流专业建设中已形成了鲜明的专业特色。本文介绍了福州大学化学专业以卢嘉锡先生的"C3H3"作为教育指导思想,以立德树人为根本,守正创新,通过课程体系、人才培养模式和实践教学体系改革等举措,化学专业建设将嘉锡精神贯穿于人才培养的全过程,取得了一定的成效。     

第六届全国化学教育高峰论坛通知

正由中国化学会化学教育委员会、《化学教育》编辑部主办,牡丹江师范学院承办的"第六届《化学教育》读者、作者、编者学术交流会暨全国化学教育高峰论坛"将于2021年7月18—21日在黑龙江省牡丹江市隆重举行。一、会议主题立德树人导向的化学学科育人内涵及方式的研究,包括基础化学教育、高等化学教育、职业教育中的化学教育、非化学专业的化学教育等。二、会议内容(1)核心素养为本的化学教学设计与实践案例;(2)核心素养为本的化学考试评价;     

化学基础教育再上新台阶化学教师教育开创新局面——化学教师教育研究中心工作的回顾与总结

2013年是中国教育学会化学教学专业委员会成立30周年,这是值得庆贺的.在以刘知新先生为代表的老一辈化学教育家的关怀下,在以张健如先生为理事长的学会第六届理事会的带领下,学会紧密团结广大会员,锐意进取,开拓创新,使得学会工作生动活泼、丰富多彩,蒸蒸日上,成绩斐然. 自学会第六届理事会2007年4月成立以来,广大高师化学教育工作者紧紧围绕"化学基础教育"和"化学教师教育"这2个核心主题,开展了一系列理论和实践研究,取得了丰硕的研究成果,极大地提升了我国化学基础教育和化学教师教育研究的科学化水平.     

第六届全国化学教育高峰论坛通知

正由中国化学会化学教育委员会、《化学教育》编辑部主办,牡丹江师范学院承办的"第六届《化学教育》读者、作者、编者学术交流会暨全国化学教育高峰论坛"将于2021年7月18-21日在黑龙江省牡丹江市隆重举行。一、会议主题立德树人导向的化学学科育人内涵及方式的研究,包括基础化学教育、高等化学教育、职业教育中的化学教育、非化学专业的化学教育等。二、会议内容(1)核心素养为本的化学教学设计与实践案例;(2)核心素养为本的化学考试评价;     

第六届全国化学教育高峰论坛通知

正由中国化学会化学教育委员会、《化学教育》编辑部主办,牡丹江师范学院承办的"第六届《化学教育》读者、作者、编者学术交流会暨全国化学教育高峰论坛"将于2021年7月18—21日在黑龙江省牡丹江市隆重举行。一、会议主题立德树人导向的化学学科育人内涵及方式的研究,包括基础化学教育、高等化学教育、职业教育中的化学教育、非化学专业的化学教育等。二、会议内容(1)核心素养为本的化学教学设计与实践案例;(2)核心素养为本的化学考试评价;     

化学学科创新人才培养的探索与实践

"化学学科创新人才培养的探索与实践",是在实践中遵循教育教学规律,勇于改革创新的教学研究实践成果。多年来,化学学科带头人携学院全体教师,致力于"国家级教学团队""国家级特色专业建设点"建设,倾心打造"精品课程""精品教材",以真正实现夯实理论与实验教学基础,提升施教水平,优化教育环境,努力构建"基础知识扎实、基本技能熟练、科研作风踏实"的创新型化学人才培养的教学平台,为化学学科创新人才的成长建立了可持续发展的保障机制。     

基于一流本科教学的植物化学类课程体系构建探索

目前全国有442所高校设置有应用化学专业,如何使该专业办出特色并具有广阔需求前景是我们亟待解决的关键问题。屠呦呦因青蒿素获得诺贝尔化学奖彰显出"植物化学成分研究"的重要性,与此同时,人类医疗与健康对植物中活性成分需求也日益增长。经过18年的教学实践与探索,紧密结合学校"双一流"农业大学使命,我们找到了以植物化学为支撑来培育应用化学长线专业在我校的一流优势与特色问题,以植物化学成为国家级精品课程的标志性成就,形成了紧扣"双一流建设"国家重大需求的西北农林科技大学应用化学专业本科教育新体系。     

关于大学"普通化学"课程定位的思考

针对"普通化学"课程如何对接普通高中课程持续改革的现状,以及如何适应"普通化学"课时数被压缩的趋势,思考应对策略,提出调整"普通化学"课程的教学理念,通过课程讲授,以化学知识为依托,让学生更多理解蕴含在化学概念、原理和结论之中,可供不同专业学生借鉴的科学观点和方法。确立以推进学生科学核心素养培养为目标的课程定位,体现以培养人为中心的教育原则。     

新时代华中师范大学国家级一流化学专业建设的思考与实践

面对新时代高等教育"双一流"建设的浪潮,高等师范院校化学专业必须有自己的特色作为。以华中师范大学化学专业(师范类)建设为例,从人才培养目标、培养方案和课程群的构建,课程的深度教学进化,教学管理新体系与新机制等三方面探讨了新时代国家级一流化学专业建设的相关问题、解决途径和实施方案与成效。     

New trends in nucleic acid based biosensors: University of Florence (Italy), 25-28 October 2003

The Workshop on "New Trends in Nucleic Acids Based Biosensors" was held at the University of Florence (Italy), from 25th to 28th October 2003. The workshop was funded by the European Science Foundation (ESF) within the programme "Functional Genomics" (Programme Area: DNA arrays and chips). This report describes the main arguments discussed during the workshop considering the state of art and the future trends in the field of nucleic acid-based biosensors, with particular attention on the aptamer field.     

Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines

New A-ring or/and C-ring modified methyl oleanolate derivatives were prepared. New simple method of synthesis of 3,12-diketone (3) from methyl oleanonate (2) was worked out. The obtained new compounds were tested for cytotoxic activity on KB, MCF-7 and HeLa cell lines. The derivatives had acetoxy, oxo or hydroxyimino function at the C-3 position and in some cases oxo, hydroxyimino or acyloxyimino group at the C-12 position. Almost all of the compounds showed strong cytotoxic activity, higher than unchanged oleanolic acid. The most active substances turned out to be the derivatives with acyloxyimino function, especially 4 and 8d.     

The cytosporones, new octaketide antibiotics isolated from an endophytic fungus

[structure] Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp.) and CR146 (Diaporthe sp.) were found to have potent antibiotic activity. Bioassay-guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites. The five new octaketides were characterized using X-ray crystallography and NMR.     

Effect of Steric and Electronic Properties of Palladium Complexes with Bidentate Diphosphine Ligands on the Basis of Diphenyl Oxide on Arylation of Amines

New complexes of palladium chloride with bidentate diphosphine ligands on the basis of 2,2′-bis(diorganylphosphino)diphenyl oxides were prepared by three methods, and their catalytic activity in arylation of amines was studied.__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 2, 2005, pp. 233–238.Original Russian Text Copyright © 2005 by Veits, Mutsenek.     

非均相金属卟啉催化剂的研究进展

本文综述了近年来非均相金属卟啉催化剂的最新研究成果,对不同类型载体的结构特点、负载方法、及催化活性进行了详细阐述。负载后的金属卟啉配合物不仅避免了二聚,提高了稳定性和活性,而且表现出较高的形状和尺寸选择性。     

New hybrid organic-inorganic nanocomposites based on functional [Ti16O16(OEt)24(OEMA)8] nano-fillers

New hybrid nanocomposites based on a methacrylate functionalized titanium-oxo cluster as nano-cross-linker show improved mechanical properties, optical transparency and photochromic activity.     

Medical education: challenges and opportunities.

New curricula and educational methods are needed in medical education to take account of changes in the material taught, and the way in which education is delivered. We describe two approaches to these challenges--an internationally developed slide-text-based program and a multimedia clinical case-based CD-ROM project.     

Naphthoquinone-derived polyol macrolides from natural sources

Russian Chemical Bulletin - New biologically active substances isolated from natural sources provide valuable information on structural motifs that are important for a specific type of activity and...     

Simple Rapid Validated RP-LC Method for the Estimation of Flurbiprofen in Rabbit Serum and Aqueous Humor

Abstract

New reversed-phase liquid chromatographic methods, with UV detection, were developed for the quantitative estimation of flurbiprofen in rabbit blood serum and aqueous humor. The mobile phase and other chromatographic conditions were optimized to minimize interference from biological matrix and at the same time provide sufficient sensitivity for the method to be adopted for in vivo studies of ophthalmic formulations of flurbiprofen. Acetonitrile was used to precipitate proteins from serum or aqueous humor during sample preparation. A mobile phase of methanol: acetonitrile: phosphate buffer pH 5.6 (40:20:40) was employed with UV detection at 248 nm for estimation of drug in both the biological matrix. The retention time and asymmetry factor for the proposed method of estimation in serum and aqueous humor was found to be 3.1312±0.0101 min and 1.1310±0.0091 respectively. The linear regression equations obtained by least square regression method, were Area (µV sec) = 52.27 × Conc. (in ng/ml)–1618.70 in serum and Area (µV sec) = 61.79 × Conc. (in ng/ml) ? 783.24 in aqueous humor. The results of analysis were treated statistically, as per ICH guidelines for validation of analytical procedures, USP-2003, and by recovery studies. The results were found to be accurate, reproducible and free from interference. The developed methods were further used for estimation of flurbiprofen in rabbit serum and aqueous humor following single topical administration of in-house aqueous drop and market formulation to rabbit eye.     

Effects of carbon source on expression of alcohol oxidase activity and on morphologic pattern of YR-1 strain, a filamentous fungus isolated from petroleum-contaminated soils

Soluble alcohol oxidase (AO) activity was detected in the supernatant fraction of a high-speed centrifugation procedure after ballistic cellular homogenization to break the mycelium from a filamentous fungus strain named YR-1, isolated from petroleum-contaminated soils. AO activity from aerobically grown mycelium was detected in growth media containing different carbon sources, including alcohols and hydrocarbons but not in glucose. In previous work, zymogram analysis conducted with crude extracts from aerobic mycelium of YR-1 strain indicated the existence of two AO enzymes originally named AO-1 and AO-2. In the present study, we were able to separate the AO-1 band into two bands depending on culture conditions, carbon source, and polyacrylamide gel electrophoresis (PAGE) separation conditions; the enzyme activity pattern in zymograms from cell-free extracts exhibited three different bands after native PAGE. New nomenclature was used for upper bands AO-1 and AO-2 and lower band AO-3, respectively. The expression of AO activity was studied in the absence of glucose in the culture media and in the presence of hydrocarbons or petroleum as sole carbon source, suggesting that AO expression could be subjected to two regulatory possibilities: carbon catabolite regulation by glucose and induction by hydrocarbons. The possibility of catabolic inhibition of AO by glucose in the active enzyme was also tested, and the results confirm that this kind of regulatory mechanism is not present in AO activity.