末端为磷酰胆碱基团的聚丁二酸丁二醇酯的酶促降解和热性能

以聚丁二酸丁二醇酯(PBS)为参照, 研究了酯酶Lipase AY30对亲水磷酰胆碱(PC)基团改性的聚丁二酸丁二醇酯(PBS-PC)的生物降解性能的影响. 结果显示, 在酯酶Lipase AY30作用下, 21 d后PBS的质量损失仅为1.9%, 而PBS-PC的质量损失了9.7%. 相同条件下扣除各自水解引起的质量损失(PBS 1.4%和PBS-PC 6.5%)后, PC亲水基团的引入对聚合物的降解起到了促进作用. 示差扫描量热(DSC)研究结果表明, 改性后的聚合物熔融温度和熔融焓降低, 玻璃化转变温度升高, 表明PC端基的引入降低了PBS的结晶能力, 非晶相结构的增多对聚合物降解有促进作用. 因此PBS-PC有望作为一种新的具有良好生物降解性和生物相容性的高分子材料, 应用于药物控释、基因治疗及组织工程等生物医用材料领域.     

可生物降解聚丁二酸丁二醇酯及其共聚物的合成及改性研究进展

聚丁二酸丁二醇酯(PBS)是一种重要的可生物降解聚合物材料,在一定程度上可以缓解由于使用传统聚合物材料造成的"白色污染"问题.其合成和改性研究受到广泛的关注.本论文对PBS的聚合工艺及方法等方面进行了综述,并对PBS材料物理或化学改性进行了阐述.     

聚丁二酸丁二酯的合成、共聚改性及功能化研究进展

聚丁二酸丁二酯(PBS)因具备良好的物理性能和加工性能而备受关注,是最具有前途的生物降解材料之一。本文总结了PBS材料合成、共聚改性及其功能化方面的研究进展。无规共聚、嵌段共聚等方法可以调节材料的力学性能、生物降解性能、热性能和结晶行为。通过与聚富马酸丁二酯无规共聚或者嵌段共聚,可以利用分子链上的双键高效引入磺酸根、羧酸、氨基等基团,提高材料的亲水性和生物相容性能,并制备PH响应性的电荷翻转胶束,拓展PBS在生物医药领域的应用。     

分子间氢键的形成对聚丁二酸丁二酯结晶熔融及动态力学行为的影响

研究了含有酚羟基的小分子添加剂双酚A(BPA)对可生物降解高分子材料聚丁二酸丁二酯(PBS)的结晶、熔融及玻璃化转变的影响.研究表明在PBS中添加BPA,使PBS的结晶能力下降、熔点降低,这源于PBS与BPA通过氢键相互作用形成复合物,破坏了PBS的规整结晶结构.动态力学热分析表明,复合物的玻璃化转变温度随着BPA含量...     

生物降解PBS聚醋的改性研究进展

聚丁二酸丁二醇酯(PBS)是一种具有良好生物降解性的聚酯,本文简述了PBS的基础物性和力学性能,综述了各种改善PBS生物降解性、生物相容性、热学和力学性能的方法,重点介绍了通过共聚、共混等方法对PBS进行改性的研究进展.     

聚丁二酸丁二醇酯在堆肥条件下的生物降解性能研究

根据ISO 14855的检测方法,研究了聚丁二酸丁二醇酯(PBS)在堆肥条件下的生物降解性能,结果 表明PBS具有良好的生物降解性,且其形态对其降解速率有显著的影响,降解速率:PBS粉末>PBS片>PBS 颗粒。对堆肥中的微生物进行分离鉴定,在所选堆肥中主要分离出四种菌株:杂色曲霉菌、青霉菌、芽包杆菌 和直杆高温多孢菌,它们对PBS的降解能力各不相同,其中最有效降解PBS的菌株是杂色曲霉菌。     

聚丁二酸丁二醇酯的研究进展

聚丁二酸丁二醇酯(PBS)是一种具有生物相容性和生物降解性的脂肪族聚酯,其在药物控制释放、手术缝合线等生物医药领域有广阔的应用前景.本文综述了PBS的合成、改性方法及其作为药物缓释载体的应用.提出今后PBS研究的重点将集中在功能化基团的引入、合成路线的简化、成本的降低及其改性后材料的相关性能等方面.     

生物降解高分子材料聚丁二酸丁二醇酯的改性研究进展

生物降解高分子材料被公认为是聚丙烯、聚乙烯等传统高分子材料造成"白色污染"的问题的重要解决方法之一。聚丁二酸丁二醇酯是重要的可生物降解的脂肪族聚酯之一,因与传统的聚丙烯、聚乙烯高分子材料具有相近的物理和力学性能,从而引起科学与工业界的广泛重视。然而,与大多数脂肪族聚酯一样,PBS材料也存在着加工、种类少、性能应用上的缺点。因此,对其通过改性拓宽用途范围的研究报道也随之增多。本文从化学、物理等改性的手段方法为着眼点,分类阐述了近些年来生物降解高分子材料聚丁二酸丁二醇酯改性研究现状与进展。     

生物基高分子阻燃涂层的研究进展

生物基高分子由于具有绿色、环保、可再生和生物降解的特性,已经逐渐被应用到包装、汽车、电子电器等领域.部分生物基高分子(如壳聚糖、淀粉等)由于具有良好的成炭性而逐渐被应用于阻燃领域.这些生物基高分子主要通过添加和涂覆的方式被引入到材料中赋予材料良好的阻燃性能.本文综述了含有壳聚糖、淀粉、DNA以及植酸等生物基高分子材料阻燃涂层的研究进展,包括每种涂层的成分、涂覆方式、阻燃效果等,并简要介绍了几种生物基功能阻燃涂层.最后,对生物基阻燃涂层的发展趋势进行了展望.     

天然高分子/聚丁二酸丁二醇酯共混物研究进展

聚丁二酸丁二醇酯(PBS)是一种热塑性脂肪族聚酯,因力学和生物降解性等性能良好而具有广泛应用前景,但仍存在拉伸强度和生物降解速率低,成本高等缺陷,限制了其应用。通过物理改性是提高其性能和应用领域的重要研究方向之一。本文综述了近年天然高分子/PBS共混物制备和性能研究,并对天然高分子/PBS共混物的发展作了总结和展望。     

热塑性淀粉/PBS共混物的微生物降解性研究

以甘油作为增塑剂,采用玉米淀粉与改性后的聚丁二酸丁二醇酯(PBS)熔融共混制备出淀粉/PBS共混材料.对这种改善了两相相容性的共混材料在特定微生物条件下的降解行为进行了研究.结果显示,共混物降解28天后,含有30%PBS的共混物质量损失达到35%左右,其力学性能只有降解前的20%,甘油含量减小和PBS含量增加均能减缓材料的降解.且随着降解时间的延长,PBS的结晶度和熔点有所提高.     

HDI作为扩链剂合成含PLLA和PBS链段的聚酯氨酯

以数均分子量为6350g/mol端羟基聚L-乳酸(PLLA-OH)与10500g/mol端羟基聚丁二酸丁二酯(PBS-OH)为预聚物,六亚甲基二异氰酸酯(HDI)为扩链剂,通过熔融反应制备了分子量高达30×104g/mol的可完全生物降解聚酯氨酯(PEU).研究了异氰酸根(NCO)与羟基比例对扩链反应的影响.结果表明,当[NCO]/[OH]=1∶1时,扩链效果最好,PEU分子量最大;PEU分子量随着预聚物中PBS含量增大而提高.通过核磁共振谱(1H-NMR)确定了PEU的结构与组成,并对聚酯氨酯进行了凝胶渗透色谱(GPC)、差示扫描量热(DSC)、热重分析(TGA)以及拉伸性能测试.DSC结果显示,扩链后PEU的结晶主要由PBS链段产生,而PLLA链段几乎不结晶;TGA结果表明,PEU的热降解分两步进行,第一步为PEU中PLLA链段的热降解,第二段为其中PBS链段的降解;拉伸测试结果表明,PBS与PLLA的共聚能够制备拉伸强度与断裂伸长率优异的聚合物材料.     

Improved biocompatibility of phosphorylcholine end-capped poly(butylene succinate)

In this work, the biocompatibility of a biomimetic, fully biodegradable ionomer phosphorylcholine (PC)-functionalized poly(butylene succinate) (PBS-PC) was investigated by means of hemolysis, platelet adhesion, protein adsorption and cytotox- icity experiments. The reference materials were poly(butylene succinate) (PBS) and chloroethylphosphoryl functionalized poly(butylene succinate) (PBS-Cl). The hemolysis rates (HR) of the leaching solutions of PBS, PBS-Cl and PBS-PC were all lower than the safe value, and the rate of PBS-PC was reduced to 1.07%. Scanning electron microscopy (SEM) measurements showed that platelet adhesion and aggregation were significant on both PBS and PBS-Cl surface. In contrast, very few platelets were observed on PBS-PC surface. Bicinchoninic acid (BCA) measurements revealed that the adsorption amounts of bovine serum albumin (BSA) and bovine plasma fibrinogen (BPF) on PBS-PC surface were 52% and 72% reduction respectively compared with those on PBS surface. Moreover, non-cytotoxicity of both PBS-PC particles and its leaching solution was sug- gested by MTT assay using mouse L929 fibroblast cells. All the results demonstrated that the biocompatibility of PBS could be greatly improved by PC end-capping strategy. This PC functionalized polyester may have potential applications in biological environments as a novel carrier for controlled drug release and scaffold for tissue engineering.     

The influence of different fillers on mechanical and physical properties of high-molecular-weight biodegradable aliphatic polyesters

Poly(ethylene succinate) and poly(butylene succinate) are synthetic biodegradable polymers, and much attention is paid to study the properties of pure polymers and the polymers modified by different comonomers and filling materials. The literature data on the physical properties of these polymers vary widely depending on their method of preparation and subsequent modifications. Most of the studies deal with low- and moderate-molecular-weight polymers or commercial grade polymers, modified by different comonomers and chain-extension agents. The data on pure high-molecular-weight polymers are scarce. In this work, we have prepared high-molecular-weight (MW range of (1.4–1.8) × 10⁵) poly(ethylene succinate) and poly(butylene succinate) by direct polycondensation at 200°C in a nitrogen flow without chain-extension agents. We have further studied the properties of pure polymers and examined the effect of different fillers (carbon nanotubes, SiO₂, Aerosil®) on the mechanical and physical properties of these polymers. Because of high-molecular-weight, the polymers possess increased tensile and storage moduli and thermostability. Even very low filler contents (up to 1 wt %) have a pronounced influence on the polymer properties: the polymer tensile and the storage modulus increases, the elongation at break decreases, and the thermal stability of the polymers decreases slightly. The effects of fillers are less pronounced compared with those for low- and moderate-molecular-weight polymers. When mixed together, poly(ethylene succinate) and poly(butylene succinate) crystallize independently from each other as evident from the mechanical and thermal analysis data.     

Synthesis of Clicked Imidazolium‐Containing Biosourced Copolymers and Application in Carbon Nanotube Dispersion

New polyesters incorporating a variable quantity of imidazolium rings along the backbone are synthesized by Huisgen 1,3‐dipolar cycloaddition (“click” reaction). Subsequently, the imidazolium‐grafted copolymers reveal an efficient dispersing ability toward the carbon nanotubes (CNTs) through supramolecular interactions in organic media. Interestingly, these compounds offer a simple and reliable strategy to control the quantity of dispersed CNTs as a function of imidazolium content. This approach is particularly suitable for the elaboration of biosourced and biodegradable materials based on poly(butylene succinate) with high‐performance properties.     

Effects of comonomer sequential structure on thermal and crystallization behaviors of biodegradable poly(butylene succinate‐co‐butylene terephthalate)s

In this work, new investigations on the effect of comonomer sequential structure on the thermal and crystallization behaviors and biodegradability have been implemented for the biodegradable poly(butylene succinate‐co‐butylene terephthalate) (PBST) as well as aliphatic poly(butylene succinate) (PBS). At first, these copolyesters were efficiently synthesized from dimethyl succinate and/or dimethyl terephthalate and 1,4‐butanediol via condensation polymerization in bulk. Subsequently, their molecular weights and macromolecular chain structures were analyzed by gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR) spectroscopy. By means of differential scanning calorimeter (DSC) and wide‐angle X‐ray diffractometer (WAXD), thermal and crystallization behaviors of these synthesized aromatic–aliphatic copolyesters were further explored. It was demonstrated that the synthesized copolyesters were revealed to have random comonomer sequential structures with thermal and crystallization properties strongly depending on their comonomer molar compositions, and that crystal lattice structures of the new crystallizable copolyesters shifted from the monoclinic crystal of semicrystalline PBS to triclinic lattice of the poly(butylene terephthalate) (PBT) with increasing the terephthalate comonomer composition, and the minor comonomer components were suggested to be trapped in the crystallizable component domains as defects. In addition, the enzymatic degradability was also characterized for the copolyesters film samples. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 1635–1644, 2006     

Technology Trends in Biodegradable Polymers: Evidence from Patent Analysis

The public and governmental awareness regarding more sustainable products have gained significant momentum in the last decade and are directing the future research of the next generation of materials and processes. In such a setting, biodegradable polymers are regarded as one of the technologies driving the innovation and current market growth because they provide an additional end of life option. Tracing the evolving trends of these emerging technologies will help researchers, investors, and policy makers to better evaluate the opportunities of the technology as well as to understand the technology's changing characteristics. Therefore, within this study, we perform bibliographic analyses based on patent information to delineate the current research landscape and to anticipate the future development trends by focusing on the cases of poly(lactic acid) (PLA), poly(hydroxyalkanoates) (PHAs), polycaprolactone (PCL), poly(butylene succinate) (PBS), and poly(butylene adipate-co-terephthalate) (PBAT). The following findings were made: First, PLA gets the highest attention from both academia and industry. Second, the overall international presence of biodegradable polymer patents is high, especially in the field of PHAs. Third, technology maturity and technology strength show that PLA is the most promising technology at present in technological terms, whereas PHAs, PCL, and PBS are uncertain technologies and PBAT has a rather low development potential.     

Release behaviors of porous poly(butylene succinate)/poly(epsilon-caprolactone) microcapsules containing indomethacin

The biodegradable poly(butylene succinate)/poly(epsilon-caprolactone) (PBS/PCL) microcapsules containing indomethacin were prepared by emulsion solvent evaporation method. The morphologies, thermal properties, and release behaviors of PBS/PCL microcapsules were investigated. As a result, the microcapsules exhibited porous and spherical form in the presence of gelatin as a surfactant. From the DSC result, the PBS/PCL microcapsules showed the two exothermic peaks meaning the melting points of PCL and PBS. The results of FT-IR and DSC proved that the PBS and PCL were mixed so that the PBS/PCL microcapsules were composed of two wall-forming materials. And the release rate of indomethacin from the microcapsules was decreased with increasing the PCL content. It was noted that an addition of PCL on the PBS led to the decrease of pore size in the PBS/PCL microcapsules.     

末端带有磷酰胆碱基团的聚丁二酸丁二醇酯的合成、表征和性能研究

采用四步反应合成了一种新的具有良好生物相容性和生物降解性的末端带有磷酰胆碱(PC)基团的聚丁二酸丁二醇酯PBS-PC. 采用1H NMR、IR、凝胶色谱(GPC)和X射线光电子能谱(XPS)表征了聚合物的结构. 同时研究了聚合物的亲疏水性能、体外降解、溶胀率和对模型药物中性红的缓释性能. 结果显示: PC基团引入, 在一定程度上提高了PBS的亲水性、降解速率、溶胀率和对中性红的缓释性能.